Vol. 9 No. 10 (2025): Tropical Journal of Natural Product Research (TJNPR)

Articles

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  A Review, Inventory Structural Aspects of Phytochemical Compounds in Hawthorn Plant and Highlighting their Properties: Towards Standardization and Authentication

  Najoua Soulo, Iliass Lahmass, Nor El houda Tahir, Badiaa Lyoussi, Zineb Benziane-Ouaritini

  4670-4687

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  Global Scenario of Antimicrobial Resistance: A Review of the Homoeopathic Perspective in Mitigating this Menace

  Ritika H. Narula, Archna Nagar, Supriya Kumari, Renu Mittal, Sunil Ramteke, Subhash Kaushik

  4688 - 4700

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  Non-Genetic Engineering Methods to Enhance Cannabinoid Production in Cannabis sp.: A Systematic Review

  Luh N. A. M. Andriani, Ida A. Astarini, Jasmine K. Karsono, I Made A. G. Wirasuta, Fainmarinat S. Inabuy

  4701 - 4723

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  In Silico Evaluation of Quercetin and CAPE as Potential Anti-Inflammatory Agents Targeting COX-2

  Vitra Nuraini Helmi, Fridianty Anggraeni, Budiastuti, Ira Widjiastuti, Kun Ismiyatin, Anis Irmawati, Meircurius Dwi Condro Surboyo, Khairul Anuar Shariff

  4723 - 4727

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  Topical Application of Geniotrigona thoracica Propolis Nanoparticle for Wound Healing in Streptozotocin-induced Type-1 Diabetic Rat Model

  Afif M. Lubis, Shabarni Gaffar, Aziiz M. Rosdianto, Nasrul Wathoni, Felix Zulhendri, Ronny Lesmana

  4728 - 4733

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  Integrating Metabolomics LC-HRMS, and Network Pharmacology of Garcinia forbesii King Leaf Extract, Potential for Treatment of Renal Ischemic Reperfusion Injury

  Azma Rosida, Nia Kania, Mohammad Rudiansyah, Fujiati Fujiati, Oski Illiandri, Wivina R Devi

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  Volatile Composition and Bioactivity Assessment of Wurfbainia schmidtii Essential Oils from Thailand

  Pornpun Siramon, Nattapon Kaisangsri, Natta Laohakunjit

  4742 – 4748

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  Optimization of Extraction Process of Flavonoid-Rich Extract From Glochidion Littorale Leaves With Anti-Inflammatory and Cytotoxic Activities Against Selected Cancer Cell Lines

  Le T P Thuy, Nguyen Q Huy, Ngo H Phong, Do V Mai

  4749 – 4758

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  Effects of Triticum aestivum L. and Triticum durum Desf. Bran Processing on Fiber Content and Consumer Acceptance of Bran-Containing Cookies

  Mariyem Chakir, Mohamed Benaddou, Mohammed Diouri

  4759 – 4766

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  Protective Effects of Peperomia pellucida Extract Against Secondhand Smoke-Induced Pulmonary Fibrosis via Antioxidant and Anti-inflammatory Pathways

  Johanes AF Kristijanto, Viky N Zahiroh, Anang Triadi, Nur Khamidah, Farida A Soetedjo

  4767 – 4774

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  Evaluation of the Acute Diuretic Activity and Acute Toxicity of Hydroethanol Extract of the Fruits of Ammodaucus leucotrichus

  Nour-Eddine Loud, Achraf Hamik, Rania Jerada, Ayoub El Hamri, Otman El-Guourrami, Abdelmounaim Laabar, Soufiane Drioua, El Amine Ajal, Abdelhak Chergui, Khalid Taghzouti, Rachid Nejjari, Imane Zakariya

  4775 – 4783

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  Cultivation of Native Tissue-Cultured Kappaphycus alvarezii Plantlets at Multiple Sites in The Myeik Archipelago, Myanmar

  Wai Mie Mie Hlaing, Tharita Kitisripanya, Kanokwan Jarukamjorn

  4784 – 4790

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  Zingiber officinale Extract Inhibits Entry of SARS-CoV-2 D614G Virus-Like Particles to 6HBE14o- cells: In Vitro and In Silico Approaches

  Miftahul Mushlih, Marlita Marlita, Kavana H. Kusuma, Yuyun I. Christina, Dinia R. Dwijayanti, Dewi Mustikaningtyas, Nashi Widodo, Muhammad S. Djati, Sri Widyarti, Muhaimin Rifa’i

  4791 – 4797

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  Cytotoxicity, Wound Healing Activity, and Antioxidant Potential of Peronema canescens Leaf Extract: An In vitro Study on B16 Melanoma Cells

  Chintiana N. Putri, Azmi Rahmadani, Muhammad R. R. Rahardhian

  4798 – 4802

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  Green-Synthesized Silver Nanoparticles from Acalypha godseffiana and Their Biofilm-Disruptive Activity against ESKAPE Pathogens

  Safiyya M Shehu, Shamsuddeen Umar, Sandeep Sharma, Sarika Sharma

  4803 – 4811

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  Enhancement of the Antibiofilm Activity Against Pseudomonas aeruginosa and Biodiesel Production Using Lipase from Cronobacter dublinensis as a Catalyst

  Sahira N. Muslim, Alaa Naseer Mohammed Ali

  4812 – 4819

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  Extraction Conditions and Chemical Profiling of Limnophila aromatica Essential Oil using GC-MS in Can Tho, Vietnam

  Nguyen T. Phat, Truong T.T. Ni, Ho K. Ngoc, Nguyen T. Dat, Nguyen V.P. Lan, Nguyen T.L. Tuyen, Pham T.T. Lien

  4820 – 4824

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  Unveiling the Bioactive Power of Apis Mellifera (L); Isolates and Their Role In Anti Inflammatory Activity

  Biju C. Ramankutty, Jyothisree Gangadharan, Ayswarya Karingali, Arunlal V. Balan, Anilasree B. Parambath, Shitha Gopalakrishnan

  4825 – 4829

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  Chronic Exposure to Various Propolis Extracts from North Sumatra Does Not Trigger Hepatic Inflammation and Autophagy Gene Expression in Wistar Rats

  Julia W. Gunadi, Diana K. Jasaputra, William Jonathan, Ronny Lesmana, Andreas Christoper, Felix Zulhendri

  4830 – 4835

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  Concordance of Radiological and Histopathological Features in a Monosodium Iodoacetate–Induced Osteoarthritis

  Kusworini Handono, Dwi Agung Prasetyo, Mirza Zaka Pratama, Cesarius Singgih Wahono, Thoha Muhadjir Albaar

  4836 – 4839

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  The Effect of Ethyl Acetate Extract of Sungkai Leaves (Peronema canescens Jack.) On Uric Acid Levels in Hyperuricemia Male Albino Mice (Mus musculus L.)

  Biomechy Oktomalioputri, Viodina K. Alifia, Noverial, Dwisari Dillasamola

  4843 – 4844

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  Ethnobotanical Study of Medicinal Plants used for Therapeutic Purposes by the Population of the Sidi Kacem region in Northeastern Morocco

  Mostafa El Khomsi, Anouar Hmamou, Nor El houda Tahiri, Soukaina El Massoudi, Meryem Doubi, Driss Hmouni

  4844 – 4860

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  Potential Reversibility of the Antifertility Effects of Papaya (Carica papaya) Seed Extract on Sperm Quality and Testicular Histopathology in Male Mice (Mus musculus)

  Eviana R. Sipahutar, Ahmad A. Amalius, Rahmawati Minhajat, Muhammad H. Cangara, Yulia Y. Djabir

  4861 – 4867

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  Natural Therapeutics Against Prostate Disorders in Guinea: An Ethnobotanical Survey and Biological Activities of Some Medicinal Plants

  Tanou V. Bah, Véronique Mégalizzi, Séré Diané, Mamadou S.T. Diallo, Mohamed K. Camara, Ansoumane Oularé, Ian Tietjen, Elhadj S. Baldé

  4868 – 4878

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  Secretome Gel from SHED for Post-Extraction Healing: Modulation of BMP2 and TNF-α Levels as Key Molecular Targets

  Nikmatus Sa’adah, Indeswati Diyatri, Chanaya Miranda, Thufailah, Mohammed A. Aljunaid, Agus A. Adriansyah, Huda R. Qaid, Rini D. Ridwan

  4879 – 4883

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  Histological Effects of Kepok Banana (Musa paradisiaca L.) Heart Extract on the Kidneys and Liver of Mice

  Elidahanum Husni, Yufri Aldi, Wiwing N. Putri, Zikri H. Hamdi

  4884 – 4889

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  Ethyl acetate Fraction of Nypa fruticans Wurmb Leaves Enhances Antihyperglycemic Activity, Insulin Secretion, Pancreatic β-cell Mass, and GLUT2 Expression

  Danang Raharjo, Haryoto, Tanti A. Sujono

  4889 – 4892

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  Efficacy and Safety of Doctor Decha’s Cannabis Oil on Sleep Quality, Quality of Life and Glycemic Control in Patients with Type 2 Diabetes: A Prospective Controlled Clinical Study

  Naruwat Pakdee, Sirinthon Audomsin, Ronnachai Poowanna

  4893 – 4898

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  In silico Study of the Inhibitory Effects of Sanguinarine and its Proposed Derivative on Phosphoinositide 3-kinase (PI3K) Isoforms

  Niran A. Al-Ogaili, Noor M. Mohammed

  4899 – 4908

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  Leaf-derived Bioactive Compounds of Elaeocarpus ganitrus as a Natural Antidepressant Agent Through Glycogen Synthase Kinase 3 Beta (GSK3β) and Serotonin 6 (5-HT6) Receptor: In silico Approach

  Cicilia N. Primiani, Pujiati Pujiati, Weka S. Bhagawan, Gabriella C. Krisnamurti, Anak A.S.A Sukmaningsih

  4909 – 4914

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  Formulation and Topical Safety Evaluation of Zanthoxylum rhetsa Spray Containing Essential Oil from Pericarp: A Phase 1, Double-blind, Non-Randomized, Single-Arm Patch Test Trial

  Chureeporn Imphat, Nanthakarn Woottisin

  4915 – 4926

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  Antioxidant, Hepatoprotective and Toxicological Assessment of Dillenia ovata in Mice

  Yen D. H. Nguyen, Tran Chi Linh, Nguyen Trong Tuan, Dai Thi Xuan Trang

  4927 – 4932

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  Rapid Spectroscopy-based Fingerprinting Combined with Data Fusion Chemometrics of Amaranthus tricolor L. for Growing Environment Discrimination

  Ayu Muthia, Daimon Syukri, Mai Efdi, Adlis Santoni

  4933 – 4938

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  Bioactive Root Extracts of Cannabis sativa Cultivars: Antioxidant and Anti-AChE Properties

  Suwadee  Chokchaisiri, Isariya Tosalee, Thanachai Thanompak, Chawalit  Yongram, Nath Tharntanaporn, Tanawat Chaiphongpachara

  4939 – 4947

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  Network Pharmacology of Thalictrum simplex var. brevipes: Linking Chemical Constituents to Hepatitis Treatment Targets

  Chiu-Fai Kuok, Pedro Fong

  4948 – 4952

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  Peperomia pellucida Herbal Tea: An Initial Assessment of Cardiovascular and Metabolic Parameters, with in Silico Insights

  Yeanneke L. Tinungki, Jelita S. H. Hinonaung, Walter Balansa

  4953 – 4966

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  Unraveling the Bioactive Potential of Side Dish Vegetables in Southern Thai Traditional Cuisine: Anti-inflammatory, Anticancer, Antibacterial, and Antioxidant Properties

  Anuchit  Phanumartwiwath, Yothin  Teethaisong, Chakkraphong Khonthun, Jirapast  Sichaem, Nawee Jantarit, Hla Myo, Desy Liana, Kongdech Savaspun, Rampai Kodsueb, Chanat Aonbangkhen, Damratsamon Surangkul, Pornpat Sam-ang

  4968 – 4975

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  Enzyme-assisted Extraction Optimization of Bioactive Phenolic Components from Phyllanthus urinaria

  Nguyen T Trang, Le N  Tam, Nguyen T  Ngan, Dinh M  Thinh

  4976 – 4985

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  Analysis of the Colour Change, Surface Roughness, and Hardness of Nanofiller Composite Resin after Exposure to Syzygium Cumini Extract Mouthwash

  Viona Diansari, Sri Fitriyani, Iin Sundari, Fitrihanna, Farah Reyzia

  4986 – 4995

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  Synergistic Inhibition of Chronic Myeloid Leukemia: Combining Imatinib and Naringin to Overcome Drug Resistance

  Kiranmai Gudime-tla, Rakesh Barik

  4996 – 5003

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  In vitro Cytoprotective Effects of Pluchea indica L. Leaf Extract on Vero Cells against Oxidative Stress: A Comparative Study of Preventive and Curative Treatments

  Violita Syukroni, Nor I. M. Ismail, Woro A. S. Tunjung

  5004 – 5009

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  Thermal Stability and Kinetic Characterization of Insect-Derived Glycosidases Using the Arrhenius Model

  Kambiré S. Marius, Gnanwa M. Jacques, Mariko Kalifa, Karamoko B. Aristide

  5010 – 5015

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  In-vitro and In-silico Assessment of the Antidiabetic and Antioxidant Potential of Urena lobata Leaf Fractions

  Yudi Purnomo, Andri Tilaqza, Denis M Mirza, Apon Z Mustopa

  5016 – 5024

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  Bibliometric Analysis of Articles on Essential Oil Nanoemulsions

  Rizky D. Larasati, Lia Puspitasari, Audi N. Yusfiya, Ahmad Ainurrofiq, Syaiful Choiri, Imam Prabowo, Hana A. Fatimi

  5025 – 5032

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  Moringa oleifera Leaf Extract Attenuates Di-(2-Ethylhexyl) Phthalate Induced Immunohepatotoxicity by Suppressing Inflammation in Rats

  Putri A. I. Setiyowati, Yuningtyaswari Yuningtyaswari, Fachdiya R. Adriyani, Risya S. Primindari, Laila A. Rohmah, Nastiti I. P. Sari

  5033 – 5041

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  Metabolites Profiling and Assessment of Antibacterial Potential of Sauropus androgynus Extracts Through in Vitro and in Silico Methods

  Nurina R. Ramadhania, Sapti Puspitarini, First A. Wati

  5042 – 5050

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  Sonneratia alba Fruit Extract’s Potential to Reduce Atherogenic Index of Plasma and Prevent Atherogenesis in Aortic Arch of High-Fat Diet Induced Wistar Rats

  Huriatul Masdar, Gusti Revilla, Eka F. Elfi, Eryati Darwin

  5051 – 5060

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  Exploring the Protein Targets of Cinnamomum zeylanicum’s Phytoconstituents Against Pathogenic Staphylococcus aureus: GC-MS Profiling, Molecular Docking, Pharmacophore Modeling, and Pathway Analysis

  Sarit Prabha, Sudeesh Warkare, Akash Ranga, Khushhali M. Pandey

  5061 – 5072

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  Cytotoxic Evaluation of Niclosamide via Saccharin-Based Multicomponent Crystal: Insights from in Vitro MTT Assay

  Indra Makmur, Salman Umar, Fatma S. Wahyuni, Rina Wahyuni, Luthfi P. P. Ronia, Erizal Zaini

  5073 – 5076

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  Molecular Docking and Dynamics Simulation of Holothuria scabra In Non-Small Cell Lung Cancer Through Inhibition of EGFR and KRAS Pathways

  Ikhwandi C. Nugraha, Ami Febriza

  5077 – 5084

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  Genotoxic Effect of Arsenic and Its Amelioration by Zinc and Selenium Administered Singly and Synergistically in Female Albino Rats

  Eniola O. Bolawa, Adegoke C. Oni, Adaeze C. Nzei, Osaretin A. T. Ebuehi

  5085 – 5089

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  Ethnobotanical Survey of Medicinal Plants from the Villages Around Ngel-Nyaki Forest Reserve, Mambila Plateau: A Nigerian Montane Forest Project

  Gayaunan Danailu, Clarkson Y. Hyela, Jedidah A. Jacob, Chinedu S. Ogbonnaya, Suleiman D. Abdul

  5090 – 5099

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  In Vivo anti-Plasmodium Potential of Aloe barbadensis Anthraquinones and its Combination with Amodiaquine

  Abdulazeez A. Abubakar, Jacob O. Arawande, Temidayo D. Adeniyi, Akinpelu Moronkeji, Oluwagbenga Aina, Shukura Salau

  5100 – 5107

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  The Neuroprotective Potential of Anacardium occidentale (Cashew) Seed Extract Against BPA-Induced Neurotoxicity in Male Wistar Rats

  Tochukwu N. Nnama, Uduak A. Inwang, Blasius O. Okwara, Somadina N. Okeke, Blessing T. Onyeje, Chikodili A. Mbah, Lotanna S. Akudu, Udenna B. Aniukwu, Chioma D.Nwosu

  5108 – 5113

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  Evaluating Pre-planting Trichoderma asperellum Application for Biocontrol of Macrophomina phaseolina in Screenhouse-Grown Cowpea

  Olusola L. Oyesola, Tonjock R. Kinge, Olufisayo A. Kolade

  5114 – 5121

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  Evaluation of the Efficacy of Some Selected Disinfectants Using the Chick-Martin Test

  Nwamaka H. Igbokwe, Peter C. Ozoaduche, Oluchi J. Osuala, Angus N. Oli

  5122 – 5127

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  Evaluation of the Antioxidant, Anxiolytic and Anti-Epileptogenic Effects of Vitex chrysocarpa Leaf

  Chinedu Enegide, Israel Ofejiro Efejene, Osasengo Precious Osifo, Nwabenu Opia Okwaji, Eugene Ehimare, Esther Adaeze Ossai, Ujunwa Emelda Ezeanochie, Emmanuella Chukwufumnanya Nwegbu

  5128 – 5132

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  Characterization of Matrix Type Diclofenac Sodium Patch as a Transdermal Delivery System: Effect of Polymer Concentration

  Ade A. Mahdiyyah, Nuzul W. Diyah, Nira Purnamasari, Esti Hendradi

  5133 - 5137

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  <i>Piper guineense</i> (Schum and Thonn) Seed Extract Exhibits Efficient Bowel Cleansing Efficacy for Radiographic Imaging in Female Wistar rats

  Samuel A. Efanga, Emmanuel O. Esien-Umo, Affiong I. Ngaji, Samson O. Paulinus, Daniel U. Owu, Itoro Efanga, Akintunde O. Akintomide

  5138 – 5143

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  Properties and Application of Luffa aegyptiaca and Citrullus lanatus Seed Lipases in the Degradation of Palm Oil Effluent (POE)

  Kenechukwu C. Uzo, Arinze L. Ezugwu, Ferdinand C. Chilaka

  5144 – 5151

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  Toxic Beauty: Evaluating the Toxicological Risks of Heavy Metals in Facial Cosmetics and Implications for Public Health in Calabar, Nigeria

  Udiba U. Udiba, Edward O. Emuru, Michael O. Odey, Alice O. Ekwu, Amah J. Etim, Mojisola O. Samuel, Keke C. Sergio, Ekom R. Akpan

  5151 – 5160

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  Anopheles gambiae Control and Antibacterial Activities of Silver, Gold, and their Alloy Nanoparticles Synthesized Using Pleurotus ostreatus

  Elijah A. Adebayo, Muinat M. Ayantola, Hassan A. Balogun, Agbaje Lateef, Musibau A. Azeez, Taofeek A. Yekeen, Lorika S. Beukes, Ntombozuko Matyumza, Evariste B. GueguimKana

  5161 – 5169

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  Impact of some Bioactive Compounds of Flavonoid-Rich Fraction of Monodora tenuifolia, Benth on Glucose Concentration and Certain Proteins Associated with Glucose Metabolism using Molecular Docking Approach

  Samuel C. Nzekwe, Adetoun E. Morakinyo, Monde Ntwasa, Sogolo L. Lebelo, Oluwafemi O. Oguntibeju, Oluboade O. Oyedapo, Samuel O. Babarinde, Ademola O. Ayeleso

  5170 – 5179

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  Molecular Docking Analysis and Anti-trypanosomal Properties of Cymbopogon citratus Ethanol Leaf Extracts

  Nanjul O. Goselle, Benard M. Matur, Nannim Nanvyat, Wilson B. Nwibari, S Udoh, Ishaku T. Samchi, Monday A. Etuh, Arin A. Hassan, Naomi N. James-Rugu

  5170 – 5178

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  Effects of Mixture of Silver Nanoparticles and Selected African Medicinal Plants on the Control of Storage Pest of Cowpea (Vigna unguiculata) Grains

  Scholastica U. Ekwueme, Florence O. Ifeanyieze, Francis M. Onu, Michael E. Ikehi, Toochukwu C. Nwakile, Christian C. Ali, Fredrick C. Onah, Benedicta A. Omeje, Eunice O. Innocent-Ene, Lilian U. Ekenta, Emeka K. Ogbonna, Chinyere R. Okwo, Chinwe. N. Ugorji

  5179 – 5188

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  Comparative Analysis of Proximate Composition, Microbial, Antioxidant and Sensory Evaluation of Yoghurts Made from Chili Pepper and Freeze Dried Starter

  Halima Suleiman, Gabriel O. Anyanwu, Gideon A. Gyebi

  5189 – 5196

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  Modulatory Effects of Some Selected Functional Foods on Physiological and Biochemical Indices of Testosterone-Dimethylbenzen(a)anthracene (DMBA)-Induced Prostate Cancer in Rats

  Nura Lawal, Karima M. Rabiu, Ganiyu I. Aderounmu

  5197 – 5207

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  Anti-Inflammatory Effects of Palm Kernel (Elaeis Guinensis) Oil Extracts on Histamine-Induced Allergic Rhinitis in Albino Wistar Rats

  Tunmise T. Oladipe, Ajayi Ajetomobi, Ademuyiwa J. Adegbegi, Ruth F. Aminu, Tayo T. Oludare, Abayomi A. Taiwo, Friday Attah, Stephen O. Omowaye, Hafsat Maiyaki

  5208 – 5216

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  Effect of Medium Components on Alkaline Protease Production using Bacillus subtilis C3a-FIIRO-MW577298 as Fermentation Strain

  Folake A. Fashola, Pauline N. Nwagala, Precious C. Augustine, Olubunmi I. Ibidapo, Opeoluwa D. Sole-Adeoye, Adekunle K. Lawal

  5226 – 5236

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  Performance And Blood Indices Of Broilers Fed Diets Containing Fermented Citrus Sinensis (Orange) Pulp Supplemented With Or Without Multi-Enzyme

  Emmanuel U. Ahiwe, Tobechukwu C. Iwuji, Francisca C. Egenuka, Ukachukwu N. Okehie, Innocent Ejifor, Chidinma A. Peter-Onoh, Ifeanyi P. Ogbuewu, Oliver O. Emenalom

  5237 – 5244

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• ERRATUM: In Vitro Evaluation of Antiglycation, Antioxidation,  and -Glucosidase Inhibitory Activities of Ethanolic Extracts of Terminalia Bellirica and Terminalia Chebula Fruits

  Benjamart Cushnie, Achida Jaruchotikamol, Prasorborn Rinthong, Nuttapong Wichai, Thanakit Chantawong, Kittiphum Phitsaphan

  5245 – 5252

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