Tropical Journal of Natural Product Research (TJNPR)

Tropical Journal of Natural Product Research (TJNPR) is the official scientific publication of the Natural Product Research group, University of Benin; and it is available in both printed and electronic formats. The journal is published monthly.

Tropical Journal of Natural Product Research (TJNPR) is a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, papers discussing the screening of natural Product for biological activity against different health targets are also encouraged.

Vol. 8 No. 9 (2024): Tropical Journal of Natural Product Research (TJNPR)

Published: 2024-10-02

The Effect of Vitamin E on Hormonal Regulations in Polycystic Ovary Syndrome (PCOS): A Review

Sabrina M. Jalani, Hannah N. Jaafar, Ruzianisra Mohamed, Siti Syairah M. Mutalip

8252-8257

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DOI: https://doi.org/10.26538/tjnpr/v8i9.1

Pharmacological and Nutritional Properties of Rosmarinus officinalis: A Comprehensive Review

Abdelhay Benyaich, Mustapha Aksissou

8258 - 8268

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DOI: https://doi.org/10.26538/tjnpr/v8i9.2

Biochemistry of Aging: Decoding the Complex Pathways to Longevity

Abraham E. Ubhenin, Joshua Ikebuiro, Fatima A. Adamude, Mohammed A. Abdulrasak, Jibril H. Limam, Kingsley Omage

8269 - 8274

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DOI: https://doi.org/10.26538/tjnpr/v8i9.3

Biochemical Composition, Polyphenol and Flavonoid Content, Antibacterial Activity of Leaf and Flower Extracts of Clerodendrum paniculatum Distributed In Thua Thien Hue Province, Viet Nam

Nguyen T. Q. Trang, Hoang X. Thao, Bui T. T. Anh

8275 - 8281

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DOI: https://doi.org/10.26538/tjnpr/v8i9.4

Teratogenic Effect of Guava (Psidium guajava L.) Leaf Extract on Mice

Ayu N. Sari, Dina E. Sari, Diky S. Diningrat

8282 - 8287

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DOI: https://doi.org/10.26538/tjnpr/v8i9.5

Limonoid Constituents of Xylocarpus granatum Fruits from Vietnam: Antioxidant, Anti-Inflammatory Activities, and Molecular Docking Studies

Hieu T. Tran, Tuan N. Nguyen, Thuy T. Phan, Chau H. M. Cao, Ping C. Kuo, Thang D. Tran

8288 - 8295

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DOI: https://doi.org/10.26538/tjnpr/v8i9.6

Effects of Mackerel Scad Collagen Gel on Superficial Non-Infected Wound in Mice

Elisa Herawati, Nafira Saraswati, Tetri Widiyani

8296-8302

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DOI: https://doi.org/10.26538/tjnpr/v8i9.7

Effects of Physalis angulata L. Fruit Extract on Endothelial Cell Migration and VEGF Concentration during Wound Healing under Hyperglycemic Conditions: An in vitro Study

Nur Permatasari, Ranny Rachmawati, Wayan A. Wiyasa, Maria E. S. Larasati, Gisha S. A. Warsan, Risa F. Gisma

8303 - 8306

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DOI: https://doi.org/10.26538/tjnpr/v8i9.8

The Impact of Amphimedon chloros Ethyl Acetate Extract on MDA-MB-231 Cell Lines' Expression of Bax, Cyclin D, Caspase 3, P21, C-myc, and Bcl2: Mechanism of inhibition of the Growth of Cancer Cells

Lamees M. Qasqas, Khaled Khleifat, Khalid A Shadid, Haitham Qaralleh, Moath Alqaraleh

8307 - 8313

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DOI: https://doi.org/10.26538/tjnpr/v8i9.9

Analgesic, Anti-Inflammatory and Anti-Gastric Ulcer Potential of Aqueous Leaf Extract of Emilia sonchifolia in Rats

Mercylyn Ezinne Uche, Chinyere Godwin Chinyere, Celestine Nwabu Ekweogu, Rutherford Ikenna Esiaba, Promise Nwankpa, Eziuche Amadike Ugbogu

8314 - 8320

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DOI: https://doi.org/10.26538/tjnpr/v8i9.10

The Impacts of Varied Durations of 1800 MHz Mobile Phone Exposure on Oxidative Stress in the Brain and Adrenal Glands of Male Wistar Rats

Irmawan Farindra, Soetjipto, Viskasari P. Kalanjati, Warda E. Rusdi, Bambang E. Suwito, Ary Andini, Irsandi R. Farmananda, Risma M. Jannah, Firdaus Arafany, Rahmat R. Ramadhany, Wilhemus D. M. R. Benge

8321 - 8325

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DOI: https://doi.org/10.26538/tjnpr/v8i9.11

Anti-osteoporotic Activity of Ethyl Cinnamate from Coix lacryma-jobi Targeting SOD and GPx Proteins

Zulaini, Zulaini, Diky Setya Diningrat, Fajar Apolo Sinaga, Ayu Nirmala Sari, Kusdianti, Ira Puspita Sari

8326 - 8331

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DOI: https://doi.org/10.26538/tjnpr/v8i9.12

Sub-Acute Toxicity of Banana (Musa Paradisiaca L.) Heart Extract on Haematological Parameters in Mice

Sarah Dhipa, Yufri Aldi, Elidahanum Husni

8332 - 8335

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DOI: https://doi.org/10.26538/tjnpr/v8i9.13

Unlocking the Therapeutic Potential: Ethanol Extract from Musa paradisiaca L. Var Sapientum Peel in the Modulation of CFA-Induced Rheumatoid Arthritis and Immunomodulatory Responses

Andi Emelda, Sukmawati, Aulia Innayahsari, Khaerunnisa, Ismail Marzuki

8336 - 8340

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DOI: https://doi.org/10.26538/tjnpr/v8i9.14

Effects of Hyperbaric Oxygen Therapy on Lungs Histopathology of Animal Models with Chronic Obstructive Pulmonary Disease

Titut Harnanik, Nabil Bahasuan, Levy P. Wibisono, Retno Budiarti

8341 - 8344

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DOI: https://doi.org/10.26538/tjnpr/v8i9.15

Network Pharmacology and Docking of Nephrolepis cordifolia as Type-2 Antidiabetic Agent

Samsul Hadi, Deni Setiawan, Noer Komari, Adi Rahmadi, Askur Rahman, Hamzah Fansuri, Kunti Nastiti, Khoirun Nisa

8345 – 835

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DOI: https://doi.org/10.26538/tjnpr/v8i9.16

Improvements of Vaginal Atrophy in Menopause with the Utilization of Natural Ingredients of Ambones Banana Blossom Extract (Musa acumintacolla) in Ovariectomy Rats

Surmiasih Surmiasih, Adi Prayitno, Brian Wasita, Ida Nurwati, Abdurahman Laqif, Eti Poncorini Pamungkasari, Soetrisno Soetrisno

8355 - 8360

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DOI: https://doi.org/10.26538/tjnpr/v8i9.17

Anti-wrinkle Effectiveness of Clay Stick Mask Formulation of Jackfruit Leaf Ethanol Extract with Scanning Electron Microscopy

Ketut A. Adrianta, Kadek R. Yustisia, Gusti A.S.A Prasanti, Ni Ketut D. P. Pratiwi, Luh A. W. I. Putri, Dwi W. Putri

8361 - 8367

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DOI: https://doi.org/10.26538/tjnpr/v8i9.18

Wound Healing Potential of Diterpenoids from the Hexane Fraction of Kaempferia galanga Rhizomes

Pattreeya Tungcharoen, Teeratad Sudsai, Prapaporn Chaniad, Supinya Tewtrakul

8368 – 8380

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DOI: https://doi.org/10.26538/tjnpr/v8i9.19

Solubility Enhancement Solid Dispersion Fenofibric Acid HPMC and Their Physicochemical Characterization

Deni Anggraini, Armon Fernando, Putri Annisa

8381 - 8384

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DOI: https://doi.org/10.26538/tjnpr/v8i9.20

Effect of Green Synthesized Magnesium Oxide Nanoparticles Using Crataegus aronia L. on Human Colon Cancer – CaCo-2 Cell Line

Sawsan A Oran, Alaa Y Ghidan, Israa F Yousef, Mariam S Alkhatib

8385 -8392

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DOI: https://doi.org/10.26538/tjnpr/v8i9.21

Antioxidant, Anti-inflammatory, Antiviral and Anticancer Potentials of Zingiberaceae Species Used as Herbal Medicine in Indonesia

Andika P. Wardana, Nanik S. Aminah, Alfinda N. Kristanti, Mochamad Z. Fahmi, Muhammad I. Abdjan, Teguh H. Sucipto

8393-8399

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DOI: https://doi.org/10.26538/tjnpr/v8i9.22

In vitro and Molecular Docking Evaluation of the Antibacterial, Antioxidant, and Antidiabetic Effects of Silver Nanoparticles from Cymbopogon citratus Leaf

Olasunkanmi K. Awote, Kehinde O. Amisu, Olajide S. Anagun, Fifame P. Dohou, Eniola R. Olokunola, Nzubechi O. Elum

8400-8411

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DOI: https://doi.org/10.26538/tjnpr/v8i9.23

Mormodica charantia L. Leaf Alleviates Menstrual Cycle Disruption and Hormonal Fluctuations In Letrozole-Induced Polycystic Ovarian Syndrome Rat

Akingbolabo Daniel Ogunlakin, Mubo Adeola Sonibare

8412-8417

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DOI: https://doi.org/10.26538/tjnpr/v8i9.24

Pro-fertility Effects of Gboma Eggplant (Solanum macrocarpon ) Leaf Extract in Female Albino Rats

Chiemekam S. Ezechukwu, Edmund C. Mbegbu, Bernard O. Mgbenka, Christopher D. Nwani, Emmanuel I. Nnamonu, Ebele A. Orji

8418-8423

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DOI: https://doi.org/10.26538/tjnpr/v8i9.25

Hypoglycaemic and Histophatological Effect of Myrianthus arboreus in AlloxanInduced Diabetic Rats

Joseph O. Ezugworie, Agatha O. Anene, Fredrick O. Ugbede

8424-8431

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DOI: https://doi.org/10.26538/tjnpr/v8i9.26

The Antiproliferative Activity of Syzygium malaccense Fruit

Moyonda Omojufehinsi, Abigail Aning, Regina Appiah-opong, Ishaya Y. Longdet, Carrol D. Luka

8432-8437

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DOI: https://doi.org/10.26538/tjnpr/v8i9.27

Colocasia esculenta Leaf Extract Mitigates Hippocampal Injury Caused by Lipopolysaccharide in Mice

Jacob A. Siyanbade, Kingsley A. Iteire, Sunday A. Adelakun, Kayode A. Adebisi, Busuyi D. Kehinde, Bala P. Akwu, Tolulope S. Oladele, Oluwafunmbi E. Ogunmiluyi

8438-8446

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DOI: https://doi.org/10.26538/tjnpr/v8i9.28

Evaluating Cashew Tree Gum as A Potential Vaccine Carrier: Purification, Phytochemical Analysis and Biocompatibility Assessment

Ola O. Olawale, Emikpe O. Benjamin, Kuntworbe Noble, Odeniyi A. Michael, Jarikre A. Theophilus, Onilude M. Opeyemi, Osei Y. Asantewaa, Asare A. Derrick

8447 – 8452

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DOI: https://doi.org/10.26538/tjnpr/v8i9.29

Biological Properties And GC-MS Identification of Compounds of Ethanol Extracts and Volatile Oils From Citrus sinensis, Citrus paradisi and Citrus reticulata

Folasade B. Oluwatobi, Olakunle B. Afolabi, Pius A. Okiki, Oghenerobor B. Akpor

8453-8460

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DOI: https://doi.org/10.26538/tjnpr/v8i9.30

Nutritional, Phytochemical and Therapeutic Attributes of Edible Wild Mushrooms as Influenced by Substrates in Humid Tropical Environment

Emmanuel I. Eze, Christian U. Agbo, Uchechukwu P. Chukwudi, Bravo U. Umeh

8461-8468

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DOI: https://doi.org/10.26538/tjnpr/v8i9.31

The Effect of Pyrolysis Temperature and Raw Materials Mass Comparison on the Characteristics of Briquettes from a Mixture of Rice Husk (Oryza sativa L.) and Jengkol Peel (Pithecellobium jiringa) Using Starch Adhesives

Rondang Tambun, Zakiyah N. Aini, Dandy R. Mulya, Vikram Alexander

8469-8473

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DOI: https://doi.org/10.26538/tjnpr/v8i9.32

Phytoconstituents Screening and Analysis of Antioxidant, Membrane Stabilizing, and Thrombolytic Properties of Leaves and Rhizomes of Schumannianthus dichotomus (Roxb.) Gagnep

Syeda F. T. Zahra, Mohammad Shahriar, Fatema T. Zohora, Sajan Das, Rumana Akter, Mohiuddin A. Bhuiyan

8474-8481

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DOI: https://doi.org/10.26538/tjnpr/v8i9.33

Phytochemical Analysis and Profiling of Possible Compounds from Simarouba glauca Leaf Extracts

Waleed M. Aljawobaei, Thippeswamy N. Boramuthi, Rajeshwara N. Achur

8482-8489

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DOI: https://doi.org/10.26538/tjnpr/v8i9.34

Verbenone and L-Arginine Attenuate Oxidative Stress in Streptozotocin-Nicotinamide Induced Diabetic Mice

Ahmad M. Ado, Fatima A. Mahmoud, Habibu Tijjani, Umar Ibrahim, Sadiq Tijani, Sadiya Alka, Ahmed Olatunde, Aminu U. Kura, Abubakar Mohammed, Oluremi A. Saliu, Oluwafemi A. Idowu, Frank E. Ebhodaghe

8490-8497

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DOI: https://doi.org/10.26538/tjnpr/v8i9.35

The Anti-Hyperglycemic and Antioxidative Effects of Aqueous Extracts from Sphenocentrum jollyanum: Evidence from In Vitro and In Vivo Studies

Oluwakemi V. Adeleke, Stephen A. Adefegha, Olorunfemi R. Molehin, Ayotomiwa T. Olowoleye, Ganiyu Oboh

8498-8503

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DOI: https://doi.org/10.26538/tjnpr/v8i9.36

Identification of Anti-Nutritional Factors and Trypsin Inhibitory Activity of Three Spontaneous Plants: Malva sylvestris L, Cynara cardunculus L, and Spinacia oleracea L

Nabahat Benmansour, Sihem Belkhiter, Mustapha Mounir Bouhenna, Houcine Boutoumi

8504-8509

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DOI: https://doi.org/10.26538/tjnpr/v8i9.37

Effectiveness of Dental Pulp Stem Cells-Secretome on Superficial Burn Wounds

Soya Loviana Hasibuan, Linda Chiuman, Edy Fachrial, Dewi Fibrini, Intan Ruspita

8510-8516

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DOI: https://doi.org/10.26538/tjnpr/v8i9.38

LC-MS Analysis, Total Phenolics Content, and DPPH Radical Scavenging Activity of Juvenile Juglans regia L. Fruit (walnut) Acetonitrile Extract

Afaf H. Al-Nadaf

8517-8522

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DOI: https://doi.org/10.26538/tjnpr/v8i9.39

Isolation, Antibacterial Screening, Phenotypic and Molecular Identification of Antimicrobial-producing Soil Streptomyces Strain

Toqa E. Al-Tarawneh, Ayat H. Al-Tarawni

8523-8526

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DOI: https://doi.org/10.26538/tjnpr/v8i9.40

Evaluation of Genetic Variation in Oreochromis Tilapia Species from South-South Nigeria using Mitochondrial DNA Hypervariable Region

Ekerette E. Ekerette, Owoidihe M. Etukudo, Jude N. Efienokwu, Hannah E. Etta, Inyang. I. Henry, Paul B. Ekpo, Ndem E. Edu, Reagan B. Agbor, Uduak. L. Edem, Ekei V. Ikpeme

8527 - 8536

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DOI: https://doi.org/10.26538/tjnpr/v8i9.41

Exploring the Analgesic, Antipyretic, and Anti-Inflammatory Properties of Annona squamosa Linnaeus Fruit Peel Extract in A Mouse Model

Tran T. P. Nhung, Le P. T. Quoc

8537 - 8545

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DOI: https://doi.org/10.26538/tjnpr/v8i9.42

Gastroprotective Effect of the Methanol Fraction of the Stem Bark Extract of Entada africana Guill. & Perr. in Wistar Rats

Millicent L. Umaru, Gabriel N. Uyaiabasi, Rabiu G. Tijjani, Celestina O. Alebiosu, Ekaete I. Oviawe, Aliyu Salihu, Abdullahi Sulaiman, Amina Y. Jega

8546 - 8553

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DOI: https://doi.org/10.26538/tjnpr/v8i9.43

Elephantopus scaber Ethanol Extract Suppresses Inflammation via Regulation of the NF-κB Pathway Expression in Pulmonary Fibrosis

Salma R. Firdausi, Riska A. R. Nur’aini, Fathiyah N. Izzah, Sarah N. Nabilah, Yuyun I. Christina, Dinia R. Dwijayanti, Sri Rahayu, Muhaimin Rifa’i, Muhammad S. Djati

8554 - 8560

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DOI: https://doi.org/10.26538/tjnpr/v8i9.44