Tropical Journal of Natural Product Research (TJNPR)

Tropical Journal of Natural Product Research (TJNPR) is the official scientific publication of the Natural Product Research group, University of Benin; and it is available in both printed and electronic formats. The journal is published monthly.

Tropical Journal of Natural Product Research (TJNPR) is a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, papers discussing the screening of natural Product for biological activity against different health targets are also encouraged.

Vol. 9 No. 4 (2025): Tropical Journal of Natural Product Research (TJNPR)

Published: 2025-04-30

Efficacy of Some Medicinal Plants Used as Antidiabetic Plants in Jordan: A Review

Israa F. Yousef, Ayoub E. Al-Jawaldeh, Ayman D. Alsheikh, Jafar M. El- Qudah, Maisa M. Al Qudah, Alia S. Khwaldeh, Yaqeen A. Rjoub

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DOI: https://doi.org/10.26538/tjnpr/v9i4.1

A Review of Momordica charantia L., Botanical Characteristics, Nutritional Properties, and Bioactive Compounds: Insights for Type 2 Diabetes Mellitus

Diem N. Le, Vinh Q. Lam, Minh Q. Le, Lan N.C Nguyen, Hoang M. Le

1375 - 1380

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DOI: https://doi.org/10.26538/tjnpr/v9i4.2

Anti-inflammatory Potential of Vernonia amygdalina Delile Extract: In Vitro Studies

Irene P. Dewi, Dachriyanus, Yufri Aldi, Nor H Ismail, Fatma S. Wahyuni

1381 – 1384

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DOI: https://doi.org/10.26538/tjnpr/v9i4.3

Effect of Geographical Locations on the Antioxidant Activity of Melastoma malabathricum L. Leaves Extracts from Riau and Riau Island Provinces, Indonesia

Dian Mayasari, Goldha Faroliu, Vonny K. Utama, Yosi B. Murti

1385 – 1390

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DOI: https://doi.org/10.26538/tjnpr/v9i4.4

Xanthones from the Roots of Garcinia rigida Miq. and Their Cytotoxic Activity against HeLa Cervical Cancer Lines

Audrey H. Zulfa, Salwa Assyifa, Ahmad R. Setiawan, Mulyadi Tanjung, Tjitjik S. Tjahjandrie, Ratih D. Saputri

1391 – 1394

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DOI: https://doi.org/10.26538/tjnpr/v9i4.5

Evaluation of the α-Amylase, α-Glucosidase, Tyrosinase Inhibitory and Photoprotective Activities of Organic Solvent and Aqueous Extracts of Retama monosperma Stem

Fatima Z. Benkhouili, Amina Moutawalli, Hanane Benzeid, Anass Doukkali, Ahmed Zahidi

1395 – 1401

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DOI: https://doi.org/10.26538/tjnpr/v9i4.6

Phytochemical Profiling, GC–MS Analysis, Antioxidant, and Antimicrobial Activities of Cannabis sativa L. var. Beldia: A Comparative Study of Four Extraction Methods

Ali Mzali, Smail Amalich, Otman El-Guourrami, Hanane Benzeid, Adil M. Mahraz, Abha C. Hassani, Ouafae Benkhnigue, Anass Doukkali

1402 – 1422

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DOI: https://doi.org/10.26538/tjnpr/v9i4.7

Ethnopharmacological Study of Aromatic and Medicinal Plants Used in the Treatment of Diabetes and Arterial Hypertension in the Laayoune Sakia El Hamra Region (Southern Morocco)

Nour-Eddine Loud, Achraf Hamik, Saloua Tajabrite, Rania Jerada, Chaimae El Kourchi, Hicham Harhar, El Amine Ajal, Abdelhak Chergui, Rachid Nejjari, Imane Zakariya

1423 - 1440

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DOI: https://doi.org/10.26538/tjnpr/v9i4.8

Effect of Casein Hydrolysates and Zinc on Insulin Resistance, Renal Function, Pancreatic and Kidney Histopathology in Diabetic Rats

Houda Z. Megherbi, Sara Aouissat, Farida O. Boukortt

1441 - 1448

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DOI: https://doi.org/10.26538/tjnpr/v9i4.9

Molecular Mechanism of Avicennia marina (Forssk.) Vierh. in Inhibiting Hepatitis C Virus Based on Network Pharmacology and Molecular Docking

Muhammad Arba, Sunandar Ihsan, Nurul Fatihah, Jamili Jamili

1449 – 1456

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DOI: https://doi.org/10.26538/tjnpr/v9i4.10

Allelopathic Effects of Essential Oils from Zingiberaceae Species on Weed Growth

Thi L. Ho, Bao D. P. Linh, Trung V. Hoang, Xuan T. T. Dao, Ngan T. Nguyen

1457 – 1463

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DOI: https://doi.org/10.26538/tjnpr/v9i4.11

Utilization potential of Pleurotus pulmonarius LAU09 (JF736658) on Crude oil contaminated Substrate

Ayomide E. Alao, Abiodun A. Ayandele, Elijah A. Adebayo, Abeke G. Adewoyin, John A. Amao

1464 - 1470

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DOI: https://doi.org/10.26538/tjnpr/v9i4.12

Investigation of the Nucleotide Sequence Variations of Genes mazE and mazF in Escherichia coli Bacteria Isolated from Clinical Sources

Zina H. Shehab, Sana MH Al-Shimmary, Shatha T. Ahmed, Zahraa A. Jabur

1471 – 1475

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DOI: https://doi.org/10.26538/tjnpr/v9i4.13

Phytochemical Screening, GC–MS Analysis, and Antibacterial Activity of Dittrichia graveolens (L.) Greuter

Salawa I. A. Eltawaty, Mohammed B. Suliman, Sanadelaslam El-Hddad, Heba K. Emgwer, Farag M. Shaieb

1476 - 1481

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DOI: https://doi.org/10.26538/tjnpr/v9i4.14

Combating Hypertension with the Dual Power of Oleic and Alpha-Linolenic Acids in Lipopolysaccharide–Induced Hypertensive Male Wistar Rats

Progress Ajayi, Adams O. Omoaghe, Iyanu Ogunnike, Joy Ikechukwu, Tony Ezike

1482 – 1486.

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DOI: https://doi.org/10.26538/tjnpr/v9i4.15

Toxicity and Aphrodisiac Activity of the Capsules Derived from the Cortex of Uvaria rufa

Burhan Ma’arif, Faisal A. Muslikh, Erly G. Boelan, Novia Maulina, Azizah Azzahra, Oashiva H. Sawjana, Efendi H. Aszari, Fadila A. Prameswari, Maximus M. Taek

1487 – 1491

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DOI: https://doi.org/10.26538/tjnpr/v9i4.16

Dechlorophyllized Urena lobata Leaf Fraction Inhibits Nitric Oxide Production in IL-1β-Induced Rat Hepatocytes

Yudi Purnomo, Mikio Nishizawa

1492 - 1495

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DOI: https://doi.org/10.26538/tjnpr/v9i4.17

Insecticidal Potential of Juniperus phoenicea Essential Oil against Callosobruchus maculatus: Chemical Composition, Biological Evaluation, and Molecular Docking Analysis

Samara Y. Khalil, El Abdali Youness, Beniaich Ghada, Mohamed Chebaibi, Taibi Mohamed, Amine Elbouzidi , Flouchi Rachid, Aimad Allali , Aouane El mahjoub

1496 – 1505

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DOI: https://doi.org/10.26538/tjnpr/v9i4.18

Enhancing Shallot (Allium cepa L.) Resilience to Salt Stress Levels through the Application of Plant Growth-Promoting Rhizobacteria and Goat Manure

Andi Kurniawan, Anna S. Karyawati, Aldila P. Rahayu, Mochammad D. Maghfoer

1506 – 1512

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DOI: https://doi.org/10.26538/tjnpr/v9i4.19

Authentication of Commercial Corn Oil Products Using Combined GC-MS and FTIR Chemometric Methods

Any Guntarti, Nina Salamah, Justitia C. Fadli

1513 – 1518

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DOI: https://doi.org/10.26538/tjnpr/v9i4.20

Potential of Garlic (Allium sativum L.) Compounds as Anti breast cancer Candidates: Computational Study

Rindi Silalahi, Anindita T. K. Pratita, Ruswanto Ruswanto

1519 – 1532

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DOI: https://doi.org/10.26538/tjnpr/v9i4.21

Comparative Study of the Insecticidal Activity of Essential Oils of Four Spontaneous and Cultivated Plants on Wheat Weevils (Sitophilus granarius L.)

Halmoune Asma, Khfif Khalid, Ait benlabchir Abdessa-mad, Koledenkova Kseniia, El Finou Hamza, El Rhaffari Lhoussaine

1533 – 1538

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DOI: https://doi.org/10.26538/tjnpr/v9i4.22

Acute Toxicity Studies of Nutmeg (Myristica fragrans Houtt.) Pulp Ethanol Extract in Balb/c Mice

Amran Nur, Ermalyanti Fiskia, Muhammad F. R. H. Yusuf, Muhammad Z. A. Disi, Yusri Sapsuha, Muhammad S. A. Sibadu, Hasyrul Hamzah

1539 - 1542

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DOI: https://doi.org/10.26538/tjnpr/v9i4.23

Effectiveness of Juwet Fruit (Syzygium cumini) in Lowering C-Reactive Protein (CRP), Rheumatoid Factor (RF), and Malondialdehyde (MDA) Levels in Rheumatoid Arthritis-Induced Wistar Rats

Sutrisno Sutrisno, Adi Prayitno, Lilik Wijayanti, Arief Nurudhin, Ida Nurwati, Eti Poncorini Pamungkasari

1543 – 1547

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DOI: https://doi.org/10.26538/tjnpr/v9i4.24

RUNX2 and ALP Expression on the Femur of Rats (Rattus norvegicus) after Implantation of Polymethylmethacrylate-Hydroxyapatite (PMMA-HA) Material

Lambang Bargowo, Felix A. Khosuma, Reza D. Hendrawan, Banun Kusumawardani, Chiquita Prahasanti, Nyoman Jujur, Mohammed A. Aljunaid, Huda R. Qaid

1548 – 1552

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DOI: https://doi.org/10.26538/tjnpr/v9i4.25

GC–MS Analysis of Bioactive Compounds of Ethanol Extract of Soybean Glycine Max (L.) Merril.

Junaidi Junaidi, Ruslan Hasani, Sitti S. Rowa, Hamsina Hamsina, Akhmad Rifai, Harliani Harliani, Hasifah Hasifah

1553 – 1558

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DOI: https://doi.org/10.26538/tjnpr/v9i4.26

Evaluation of Substrate Effects on the Acclimatization of Two Endangered Curcuma Species

Sarayut Rakarcha, Thitima Tharawoot, Janjira Muenrew, Woranart Thammarong, Piyaporn Saensouk, Surapon Saensouk

1559 - 1565

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DOI: https://doi.org/10.26538/tjnpr/v9i4.27

Na/K ratio and Micronutrients in Carica papaya Seed: Potential Health Benefits and Effects of Solvents and Drying Techniques

Ayomadewa M. Olatunya, Stella O. Olaoye, Ibukun O. Arogundade, Oladele S. Olatunya

1566 - 1573

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DOI: https://doi.org/10.26538/tjnpr/v9i4.28

Justicia carnea Extract Mitigates TNBS-Induced Liver Inflammation by Ameliorating Oxidative Stress, Improving Liver Function Indices and Normalizing NF-κB/Caspase 3 Expression

Enaohwo T. Mamerhi, Orororo C. Osuvwe, Jaiyeoba-ojigho E Jennifer, Dunkwu C. Cyril, Enyi C. Kingsley, Oghaimeh O. Grace

1574 – 1583

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DOI: https://doi.org/10.26538/tjnpr/v9i4.29

Isolation and Assessment of Sterculia foetida Gum as a Pharmaceutical Gelling Agent

Quan M. Le, Trinh K. T. Nguyen, Tuyen H. Nguyen, Uyen T. T. Pham, Huyen T. Tran, Ha V. Nguyen

1584 - 1591

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DOI: https://doi.org/10.26538/tjnpr/v9i4.30

Chemical Components, Antioxidant and Antihyperglycemic Activities of a Folklore Recipe from Thai Traditional Medicine

Ampa Konsue, Ladachart Taepongsorat

1592 – 1598

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DOI: https://doi.org/10.26538/tjnpr/v9i4.31

Antibacterial Evaluation, In Silico Study and ADMET Properties of Local Lawsonia inermis Leaves Extract

Zainab R. Abdulhussein, Munther A. Muhammad-Ali, Ekhlas Q. Jasim

1599 – 1609

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DOI: https://doi.org/10.26538/tjnpr/v9i4.32

Antifungal Activity of Ethanol Extracts of Ganoderma resinaceum against Vaginal Fungal Isolates

Farah H. Al-Qursh, Israa A. Ali

1610 – 1615

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DOI: https://doi.org/10.26538/tjnpr/v9i4.33

In Silico Screening of New Derivatives as Inhibitors of Enoyl-[Acyl-Carrier-Protein] Reductase From Staphylococcus Aureus Via 2D-QSAR Analysis, Molecular Docking and ADME/Tox Prediction

Asmae Mahtal, Hamid Toufik, Toufik Akabli, Fatima Lamchouri

1616 – 1624

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DOI: https://doi.org/10.26538/tjnpr/v9i4.34

Molecular Dynamics Study of Thymoquinone and Madecassoside as Potential Anti-Parkinson’s Agents via Dopamine D2 Receptor Modulation

Shinta Kusumawati, Agustina T. Endharti, Farhad Balafif, Shahdevi N. Kurniawan, Rabjhany Anaqah, Husnul Khotimah

1625 – 1630

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DOI: https://doi.org/10.26538/tjnpr/v9i4.35

HPLC Method Development for the Separation and Quantitative Determination of Rg1 and Re Ginsenosides from Tissue Culture

Marzella D. Rossardy, Azminah Azminah, Ratih Ratih, Johan Sukweenadhi, Krisyanti Budipramana

1631 – 1639

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DOI: https://doi.org/10.26538/tjnpr/v9i4.36

Annona muricata Prevents Cadmium-Induced Testicular Dysfunction Via Nrf2/Nfkb-Dependent Mechanisms in Male Wistar Rats

Ayodeji J. Ajibare, Adeyemi F. Odetayo, Oluwatobiloba A. Oriowo, Olabode O. Akintoye, Isaac A. Oriyomi, Joshua F. Adedara, Ezekiel A. Olugbogi, Oyaname M. Adejumo, Oluwagbenga M. Adu, Eniola O. Adesanya, Oyesanmi A Fabunmi

1640 – 1646

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DOI: https://doi.org/10.26538/tjnpr/v9i4.37

Tridax Procumbens Leaf Ameliorates Crude Oil-Contaminated Water-Induced Erectile Dysfunction by Mopping Cavernosa Free Radicals and Upregulating Phosphodiesterase 5 and Testosterone

Shakiru A. Salami, Benjamin A. Adefalujo, Saka A. Bamiro, Mushafau A. Akinsanya, Babatunde A. Murtala

1647 – 1653

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DOI: https://doi.org/10.26538/tjnpr/v9i4.38

Advancing Food Sustainability in Nigeria: Biotechnological Strategies amidst Climate Change Challenges

Olawole O. Obembe, Tobi T. Obadire, Princess P-M.P Tawari

1654 – 1664

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DOI: https://doi.org/10.26538/tjnpr/v9i4.39

Impact of Starter Culture Fermentation on the Nutritive Quality of Multigrain Ogi Enriched with Tigernut Flour

Olasunmbo A. Ajayi, Praise O. Odebode

1665 – 1671

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DOI: https://doi.org/10.26538/tjnpr/v9i4.40

Haematological and Histopathological Effects of Ethanol Extract of Bauhinia variegata (Linn.) on the Brain, Lungs and Spleen of Wistar Rats

Joseph T. Opeyemi, Joseph S. Oyepata, Zubairu A. Sabastine, Onyia F. Chukwuebuka

1672 – 1677

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DOI: https://doi.org/10.26538/tjnpr/v9i4.41

Evaluation of Anxiolytic and Behavioral Activity of Ethyl Acetate Leaf Extract of Zizzyphus spina Christi leaves in Swiss Albino Mice

Hamidu L Jabba, Igbayilola Y Dimeji, Adelaiye A Babatunde, Zakari M Baba, Adekola S Ayodeji, Saka W Adeoye

1678 – 1683

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DOI: https://doi.org/10.26538/tjnpr/v9i4.42

Estrogenic and Antiestrogenic Effects of Methanol Extract of Persea americana Pulp on the Uterus of Immature Female Albino Wistar Rat

Ekemini I. Johnson, Akpan U. Ekanem, Vitalis C. Ezeuko, Kingsley Okon, Ebube Ochu

1684 – 1690

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DOI: https://doi.org/10.26538/tjnpr/v9i4.43

Characterization and Antioxidant Activity Test of Snakehead Fish (Channa striata) Extract: Potential for Immune Enhancement and Inflammation Control

Tina F.C. Panjaitan, Saidun Fiddaroini, Eddy Suprayitno, Aulanni'am Aulanni'am, Hardoko Hardoko

1691 – 1699

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DOI: https://doi.org/10.26538/tjnpr/v9i4.44

Regulation of the Cell Cycle and Induction of Apoptosis in 4T1 Breast Cancer Cells by Phenolic Compound from Sterculia quadrifida Bark

Rollando Rollando, Eva Monica, Haryanto F.X. Susanto, Ellyvina Setya Dhini, Annisa Lazuardy, Viol Dhea Kharisma, Dodi Iskandar, Arif N. M. Ansori

1700 – 1705

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DOI: https://doi.org/10.26538/tjnpr/v9i4.45

The Effect of Ethanol Extract from Salacca zalacca (Gaertn.) Voss Peel on Antioxidant and Uric Acid Levels in Hyperuricemia Rats

Danis Pertiwi, Andina P. Aulia, Joko W. Wibowo, Maritsatun Nisa, Dede Guscella, Natasya Anggita

1706 – 1710

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DOI: https://doi.org/10.26538/tjnpr/v9i4.46

Larvicidal Effects of Ethanol Leaf Extracts of Artemisia annua, Cymbopogon citratus and Mentha piperita Against Anopheles and Culex Mosquito Larvae

Usman A. Saeed, Nannim Nanvyat, Likita P. Mamot, Isah Luka, Mark Samson, Eche O. Otakpa, Georgina S. Mwansat

1711 – 1716

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DOI: https://doi.org/10.26538/tjnpr/v9i4.47

The Effect of Packaged Tea Beverages on Biofilm Thickness of Staphylococcus aureus and MRSA: A Laboratory Experimental Study

Arin N. Zhafira, Agung Dwi W. Widodo, Nurmawati Fatimah, Mohammad F. Qorib

1717 – 1721

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DOI: https://doi.org/10.26538/tjnpr/v9i4.48

Exploring the Antibiotic Resistance Profiles of Bacterial Isolates and the Potential of Hibiscus rosa-sinensis Extracts as Alternative Treatment Options

Chizoba M. Enemchukwu, Chizaramoku Ubiaru, Elijah Ekwuta Onu, Charles O. Nnadi

1722 – 1728

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DOI: https://doi.org/10.26538/tjnpr/v9i4.49

Osteogenic Effects of PMMA-HA Implants: Enhanced Osteocalcin and Osteopontin Expression in Experimental Rats

Huda R Qaid, Rini D Ridwan, Mohammed A Aljunaid, Josephine Yessi, Dita S Suwardi, Chiquita Prahasanti, Hendrik S Budi, Mohammed S Al-Ak’hali, Baleegh A Alkadasi

1729 – 1734

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DOI: https://doi.org/10.26538/tjnpr/v9i4.50

Isolation and Characterization of Secondary Metabolites from the Twigs and Leaves of Diospyros phuwuaensis and their Cytotoxicity Activity

Saranchana Tata, Wilart Pompimon, Wipanoot Baison, Yaowares Chusiri, Saranya Wattananon, Narong Nuntasaen, Kanoknetr Suksen, Arthit Chairoungdua, Jitra Limthongkul, Chanita Naparswad, Suttiporn Pikulthong, Atchara Kaewnoi, Phansuang Udomputtimekakul

1735 – 1739

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DOI: https://doi.org/10.26538/tjnpr/v9i4.51