Tropical Journal of Natural Product Research (TJNPR) is the official scientific publication of the Natural Product Research group, University of Benin; and it is available in both printed and electronic formats. The journal is published monthly.

Tropical Journal of Natural Product Research (TJNPR) is a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, papers discussing the screening of natural Product for biological activity against different health targets are also encouraged.

Vol. 9 No. 4 (2025): Tropical Journal of Natural Product Research (TJNPR)

Published: 2025-04-30

Efficacy of Some Medicinal Plants Used as Antidiabetic Plants in Jordan: A Review

Israa F. Yousef, Ayoub E. Al-Jawaldeh, Ayman D. Alsheikh, Jafar M. El- Qudah, Maisa M. Al Qudah, Alia S. Khwaldeh, Yaqeen A. Rjoub
DOI: https://doi.org/10.26538/tjnpr/v9i4.1
DOI: https://doi.org/10.26538/tjnpr/v9i4.2

Anti-inflammatory Potential of Vernonia amygdalina Delile Extract: In Vitro Studies

Irene P. Dewi, Dachriyanus, Yufri Aldi, Nor H Ismail, Fatma S. Wahyuni

1381 – 1384

DOI: https://doi.org/10.26538/tjnpr/v9i4.3
DOI: https://doi.org/10.26538/tjnpr/v9i4.4

Xanthones from the Roots of Garcinia rigida Miq. and Their Cytotoxic Activity against HeLa Cervical Cancer Lines

Audrey H. Zulfa, Salwa Assyifa, Ahmad R. Setiawan, Mulyadi Tanjung, Tjitjik S. Tjahjandrie, Ratih D. Saputri

1391 – 1394

DOI: https://doi.org/10.26538/tjnpr/v9i4.5
DOI: https://doi.org/10.26538/tjnpr/v9i4.6

Phytochemical Profiling, GC–MS Analysis, Antioxidant, and Antimicrobial Activities of Cannabis sativa L. var. Beldia: A Comparative Study of Four Extraction Methods

Ali Mzali, Smail Amalich, Otman El-Guourrami, Hanane Benzeid, Adil M. Mahraz, Abha C. Hassani, Ouafae Benkhnigue, Anass Doukkali

1402 – 1422

DOI: https://doi.org/10.26538/tjnpr/v9i4.7

Ethnopharmacological Study of Aromatic and Medicinal Plants Used in the Treatment of Diabetes and Arterial Hypertension in the Laayoune Sakia El Hamra Region (Southern Morocco)

Nour-Eddine Loud, Achraf Hamik, Saloua Tajabrite, Rania Jerada, Chaimae El Kourchi, Hicham Harhar, El Amine Ajal, Abdelhak Chergui, Rachid Nejjari, Imane Zakariya

1423 - 1440

DOI: https://doi.org/10.26538/tjnpr/v9i4.8
DOI: https://doi.org/10.26538/tjnpr/v9i4.9
DOI: https://doi.org/10.26538/tjnpr/v9i4.10

Allelopathic Effects of Essential Oils from Zingiberaceae Species on Weed Growth

Thi L. Ho, Bao D. P. Linh, Trung V. Hoang, Xuan T. T. Dao, Ngan T. Nguyen

1457 – 1463

DOI: https://doi.org/10.26538/tjnpr/v9i4.11

Utilization potential of Pleurotus pulmonarius LAU09 (JF736658) on Crude oil contaminated Substrate

Ayomide E. Alao, Abiodun A. Ayandele, Elijah A. Adebayo, Abeke G. Adewoyin, John A. Amao

1464 - 1470

DOI: https://doi.org/10.26538/tjnpr/v9i4.12
DOI: https://doi.org/10.26538/tjnpr/v9i4.13

Phytochemical Screening, GC–MS Analysis, and Antibacterial Activity of Dittrichia graveolens (L.) Greuter

Salawa I. A. Eltawaty, Mohammed B. Suliman, Sanadelaslam El-Hddad, Heba K. Emgwer, Farag M. Shaieb

1476 - 1481

DOI: https://doi.org/10.26538/tjnpr/v9i4.14
DOI: https://doi.org/10.26538/tjnpr/v9i4.15

Toxicity and Aphrodisiac Activity of the Capsules Derived from the Cortex of Uvaria rufa

Burhan Ma’arif, Faisal A. Muslikh, Erly G. Boelan, Novia Maulina, Azizah Azzahra, Oashiva H. Sawjana, Efendi H. Aszari, Fadila A. Prameswari, Maximus M. Taek

1487 – 1491

DOI: https://doi.org/10.26538/tjnpr/v9i4.16
DOI: https://doi.org/10.26538/tjnpr/v9i4.17

Insecticidal Potential of Juniperus phoenicea Essential Oil against Callosobruchus maculatus: Chemical Composition, Biological Evaluation, and Molecular Docking Analysis

Samara Y. Khalil, El Abdali Youness, Beniaich Ghada, Mohamed Chebaibi, Taibi Mohamed, Amine Elbouzidi , Flouchi Rachid, Aimad Allali , Aouane El mahjoub

1496 – 1505

DOI: https://doi.org/10.26538/tjnpr/v9i4.18
DOI: https://doi.org/10.26538/tjnpr/v9i4.19
DOI: https://doi.org/10.26538/tjnpr/v9i4.20
DOI: https://doi.org/10.26538/tjnpr/v9i4.21

Comparative Study of the Insecticidal Activity of Essential Oils of Four Spontaneous and Cultivated Plants on Wheat Weevils (Sitophilus granarius L.)

Halmoune Asma, Khfif Khalid, Ait benlabchir Abdessa-mad, Koledenkova Kseniia, El Finou Hamza, El Rhaffari Lhoussaine

1533 – 1538

DOI: https://doi.org/10.26538/tjnpr/v9i4.22

Acute Toxicity Studies of Nutmeg (Myristica fragrans Houtt.) Pulp Ethanol Extract in Balb/c Mice

Amran Nur, Ermalyanti Fiskia, Muhammad F. R. H. Yusuf, Muhammad Z. A. Disi, Yusri Sapsuha, Muhammad S. A. Sibadu, Hasyrul Hamzah

1539 - 1542

DOI: https://doi.org/10.26538/tjnpr/v9i4.23
DOI: https://doi.org/10.26538/tjnpr/v9i4.24

RUNX2 and ALP Expression on the Femur of Rats (Rattus norvegicus) after Implantation of Polymethylmethacrylate-Hydroxyapatite (PMMA-HA) Material

Lambang Bargowo, Felix A. Khosuma, Reza D. Hendrawan, Banun Kusumawardani, Chiquita Prahasanti, Nyoman Jujur, Mohammed A. Aljunaid, Huda R. Qaid

1548 – 1552

DOI: https://doi.org/10.26538/tjnpr/v9i4.25

GC–MS Analysis of Bioactive Compounds of Ethanol Extract of Soybean Glycine Max (L.) Merril.

Junaidi Junaidi, Ruslan Hasani, Sitti S. Rowa, Hamsina Hamsina, Akhmad Rifai, Harliani Harliani, Hasifah Hasifah

1553 – 1558

DOI: https://doi.org/10.26538/tjnpr/v9i4.26

Evaluation of Substrate Effects on the Acclimatization of Two Endangered Curcuma Species

Sarayut Rakarcha, Thitima Tharawoot, Janjira Muenrew, Woranart Thammarong, Piyaporn Saensouk, Surapon Saensouk

1559 - 1565

DOI: https://doi.org/10.26538/tjnpr/v9i4.27

Na/K ratio and Micronutrients in Carica papaya Seed: Potential Health Benefits and Effects of Solvents and Drying Techniques

Ayomadewa M. Olatunya, Stella O. Olaoye, Ibukun O. Arogundade, Oladele S. Olatunya

1566 - 1573

DOI: https://doi.org/10.26538/tjnpr/v9i4.28

Justicia carnea Extract Mitigates TNBS-Induced Liver Inflammation by Ameliorating Oxidative Stress, Improving Liver Function Indices and Normalizing NF-κB/Caspase 3 Expression

Enaohwo T. Mamerhi, Orororo C. Osuvwe, Jaiyeoba-ojigho E Jennifer, Dunkwu C. Cyril, Enyi C. Kingsley, Oghaimeh O. Grace

1574 – 1583

DOI: https://doi.org/10.26538/tjnpr/v9i4.29

Isolation and Assessment of Sterculia foetida Gum as a Pharmaceutical Gelling Agent

Quan M. Le, Trinh K. T. Nguyen, Tuyen H. Nguyen, Uyen T. T. Pham, Huyen T. Tran, Ha V. Nguyen

1584 - 1591

DOI: https://doi.org/10.26538/tjnpr/v9i4.30
DOI: https://doi.org/10.26538/tjnpr/v9i4.31
DOI: https://doi.org/10.26538/tjnpr/v9i4.32
DOI: https://doi.org/10.26538/tjnpr/v9i4.33
DOI: https://doi.org/10.26538/tjnpr/v9i4.34

Molecular Dynamics Study of Thymoquinone and Madecassoside as Potential Anti-Parkinson’s Agents via Dopamine D2 Receptor Modulation

Shinta Kusumawati, Agustina T. Endharti, Farhad Balafif, Shahdevi N. Kurniawan, Rabjhany Anaqah, Husnul Khotimah

1625 – 1630

DOI: https://doi.org/10.26538/tjnpr/v9i4.35

HPLC Method Development for the Separation and Quantitative Determination of Rg1 and Re Ginsenosides from Tissue Culture

Marzella D. Rossardy, Azminah Azminah, Ratih Ratih, Johan Sukweenadhi, Krisyanti Budipramana

1631 – 1639

DOI: https://doi.org/10.26538/tjnpr/v9i4.36

Annona muricata Prevents Cadmium-Induced Testicular Dysfunction Via Nrf2/Nfkb-Dependent Mechanisms in Male Wistar Rats

Ayodeji J. Ajibare, Adeyemi F. Odetayo, Oluwatobiloba A. Oriowo, Olabode O. Akintoye, Isaac A. Oriyomi, Joshua F. Adedara, Ezekiel A. Olugbogi, Oyaname M. Adejumo, Oluwagbenga M. Adu, Eniola O. Adesanya, Oyesanmi A Fabunmi

1640 – 1646

DOI: https://doi.org/10.26538/tjnpr/v9i4.37
DOI: https://doi.org/10.26538/tjnpr/v9i4.38
DOI: https://doi.org/10.26538/tjnpr/v9i4.39
DOI: https://doi.org/10.26538/tjnpr/v9i4.40
DOI: https://doi.org/10.26538/tjnpr/v9i4.41

Evaluation of Anxiolytic and Behavioral Activity of Ethyl Acetate Leaf Extract of Zizzyphus spina Christi leaves in Swiss Albino Mice

Hamidu L Jabba, Igbayilola Y Dimeji, Adelaiye A Babatunde, Zakari M Baba, Adekola S Ayodeji, Saka W Adeoye

1678 – 1683

DOI: https://doi.org/10.26538/tjnpr/v9i4.42
DOI: https://doi.org/10.26538/tjnpr/v9i4.43

Characterization and Antioxidant Activity Test of Snakehead Fish (Channa striata) Extract: Potential for Immune Enhancement and Inflammation Control

Tina F.C. Panjaitan, Saidun Fiddaroini, Eddy Suprayitno, Aulanni'am Aulanni'am, Hardoko Hardoko

1691 – 1699

DOI: https://doi.org/10.26538/tjnpr/v9i4.44

Regulation of the Cell Cycle and Induction of Apoptosis in 4T1 Breast Cancer Cells by Phenolic Compound from Sterculia quadrifida Bark

Rollando Rollando, Eva Monica, Haryanto F.X. Susanto, Ellyvina Setya Dhini, Annisa Lazuardy, Viol Dhea Kharisma, Dodi Iskandar, Arif N. M. Ansori

1700 – 1705

DOI: https://doi.org/10.26538/tjnpr/v9i4.45

The Effect of Ethanol Extract from Salacca zalacca (Gaertn.) Voss Peel on Antioxidant and Uric Acid Levels in Hyperuricemia Rats

Danis Pertiwi, Andina P. Aulia, Joko W. Wibowo, Maritsatun Nisa, Dede Guscella, Natasya Anggita

1706 – 1710

DOI: https://doi.org/10.26538/tjnpr/v9i4.46

Larvicidal Effects of Ethanol Leaf Extracts of Artemisia annua, Cymbopogon citratus and Mentha piperita Against Anopheles and Culex Mosquito Larvae

Usman A. Saeed, Nannim Nanvyat, Likita P. Mamot, Isah Luka, Mark Samson, Eche O. Otakpa, Georgina S. Mwansat

1711 – 1716

DOI: https://doi.org/10.26538/tjnpr/v9i4.47
DOI: https://doi.org/10.26538/tjnpr/v9i4.48
DOI: https://doi.org/10.26538/tjnpr/v9i4.49

Osteogenic Effects of PMMA-HA Implants: Enhanced Osteocalcin and Osteopontin Expression in Experimental Rats

Huda R Qaid, Rini D Ridwan, Mohammed A Aljunaid, Josephine Yessi, Dita S Suwardi, Chiquita Prahasanti, Hendrik S Budi, Mohammed S Al-Ak’hali, Baleegh A Alkadasi

1729 – 1734

DOI: https://doi.org/10.26538/tjnpr/v9i4.50

Isolation and Characterization of Secondary Metabolites from the Twigs and Leaves of Diospyros phuwuaensis and their Cytotoxicity Activity

Saranchana Tata, Wilart Pompimon, Wipanoot Baison, Yaowares Chusiri, Saranya Wattananon, Narong Nuntasaen, Kanoknetr Suksen, Arthit Chairoungdua, Jitra Limthongkul, Chanita Naparswad, Suttiporn Pikulthong, Atchara Kaewnoi, Phansuang Udomputtimekakul

1735 – 1739

DOI: https://doi.org/10.26538/tjnpr/v9i4.51
DOI: https://doi.org/10.26538/tjnpr/v9i4.52

Combined Administration of Allium sativum Bulbs and Justicia carnea Leaves Hydroethanol Extracts Exacerbated Cadmium Chloride-Induced Hepatorenal Toxicity

Sylvanus Beredugo, Yibala I. Oboma, Ikhide G. Ilegbedion, Emmanuel U. Eric, Owajioniro G. Mordecai, Onome C. Sadjere

1806 - 1812

DOI: https://doi.org/10.26538/tjnpr/v9i4.53
DOI: https://doi.org/10.26538/tjnpr/v9i4.54

Anti-Inflammatory Activity of Some Characteristic Constituents of Spatholobus littoralis Root Wood Extract: In Vitro and In Silico Studies

Sri Atun, Nurfina Aznam, Suwardi Suwardi, Siti Nurjanah, Rhizma Az-Zahra, Aura C. B. Garinda, Rizki Damara, Evelyn Octaviani, Aditi Sangal

1818 – 1823

DOI: https://doi.org/10.26538/tjnpr/v9i4.55

Evaluation of UV-Absorbing Capacity, Antioxidant and Antibacterial Activities of Natural Dyes Used in Indonesian Traditional Batik

Abdeellah Fahmi Nugraha, Made D. W. Kamajaya, Wulan Trisnani, Eriyanto Yusnawan, Ari Satia Nugraha

1827 – 1832

DOI: https://doi.org/10.26538/tjnpr/v9i4.56

Xanthones from the Roots of Garcinia rigida Miq. and Their Cytotoxic Activity against HeLa Cervical Cancer Lines

Audrey H. Zulfa, Salwa Assyifa, Ahmad R. Setiawan, Mulyadi Tanjung, Tjitjik S. Tjahjandrie, Ratih D. Saputri

1833 – 1836

DOI: https://doi.org/10.26538/tjnpr/v9i4.57

Potential Lactogenic Effects in Extract Combinations of Carica papaya.L and Sauropus androgynus Leaves

Dewi Kurniati, Rul A. Syarif, Mae S. H. Wahyuningsih, Ekawaty L. Haksari

1837 - 1842

DOI: https://doi.org/10.26538/tjnpr/v9i4.58
DOI: https://doi.org/10.26538/tjnpr/v9i4.59
DOI: https://doi.org/10.26538/tjnpr/v9i4.60
DOI: https://doi.org/10.26538/tjnpr/v9i4.61

Antibacterial Potentiation Activities of Newbouldia laevis Against Some Members of ESKAPE Pathogens Isolated from Hospital Environments

Helen U. Ugwoke, James N. Ezema, Cyril C. Adonu, Chinwe B. Chinaka, Zikora G. Anyaegbunam, Claret C. Aduba, Emmanuel A. Eze

1868 – 1877

DOI: https://doi.org/10.26538/tjnpr/v9i4.62

Anti-dermatophytic potentials of Garcinia kola and Vernonia amygdalina extracts

Henrietta I Obi, Ogechukwu C Dozie-Nwakile, Somtochukwu R Ewuzie, Ifeanyi J Okeke, Angus N Oli, Calistus D Nwakile Nwakile

1878 – 1881

DOI: https://doi.org/10.26538/tjnpr/v9i4.63
DOI: https://doi.org/10.26538/tjnpr/v9i4.64
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