Vol. 9 No. 9 (2025): Tropical Journal of Natural Product Research (TJNPR)

Articles

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  Micromelum minutum: A Review of Its Traditional Uses, Chemical Constituents and Pharmacological Activities

  Rollando Rollando

  4066 - 4083

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• ERRATUM: Phaleria macrocarpa Extract Reduced Endometriosis Lesions through Regulating Inflammatory Pathway, Inhibiting Ki67 and VEGF-A on Mice Model

  Maharani Maharani, Sutrisno Sutrisno, Sri Winarsih, Agustina Tri Endharti, I Wayan Arsana Wiyasa, Husnul Khotimah, I Wayan Agung Indrawan, Hendy Hendarto

  4670 – 4676

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  Phytochemical Composition and Pharmacological Potential of Sophora flavescens: A Mini Review

  Mostafa M. Atiyah, Sijo Asokan, Smitha Vijayan

  4084 - 4093

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  Potential of Turmeric and Mangosteen in Combating High-Fat Diet-Induced Inflammation and Gut Dysbiosis: A Review

  Diana K. Jasaputra, Julia W. Gunadi, Penny S. Martioso, Laura G. Hidajat, Reynard S. Tungerapan, Filana F. Ardhinata, Elza S. Rusfaidah

  4094 - 4100

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  Potential of Green-Synthesized Silver Nanoparticles from Herbal Plants as Anticancer Therapy: A Systematic Review of Anticancer Effectiveness

  Christian K. Ngabdi, Raisha A. Fatiha, Jihan S. Azizah, Bayu Lestari, Nik A.N.N. Malek, Yanuar R. Fauzi, Shingo Nakahata, Muhammad Anshory, Holipah Holipah, Ayunda D. J. Putri, Happy K. Permatasari

  4066 – 4083

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  Effects of Quercetin Administration on TNF-α, IL-6, Hydroxyproline, and Ashcroft Scores in Preclinical Study of Pulmonary Fibrosis: A Systematic Review and Meta-Analysis

  Lukman N. Rahman, Gondo Mastutik, Anny S. Rahaju

  4111 – 4116

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  The Use of Medicinal Plants During the COVID-19 Pandemic in Meknes, Morocco: A Cross-Sectional Survey

  Omaima El Bouazzi, Samira Jaouhar, Dounia Benammi, Rachid Flouchi, Mohamed Chebaibi, Abdelhakim El Ouali Lalami, Jawad Bouzid, Zainab Toujami

  4117 – 4124

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  Study on the Attitudes, Perceptions, and Behaviors of Youth on the Use of Thai Traditional Medicine in Singhanakhon District, Songkhla Province, Thailand

  Ketkanok Pongnuruk, Kasetchai Laeheem

  4125 – 4129

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  Effects of Parboiled Immature Rice Starch (Oryza sativa L.) on Glucose and Lipid Metabolisms in High Fat Diet-induced Obese Mice

  Jirawan Oonmetta-Aree, Wassana Phanurak, Varavut Tanamool, Ratchadaporn Oonsivilai, Jittra Singthong, Catthareeya Sukwan

  4130 – 4136

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  Chitosan Nanoparticles as a Therapeutic Agent for Mitigating Paracetamol-Induced Liver Damage in White Male Albino Rats

  Ola Al-Bhadly, Intidhar M. Mnati

  4137 – 4142

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  The Effect of 96% Ethanol Extract of Semanggi leaves (Marsilea crenata Presl.) on Locomotor Activity and Alpha-synuclein Aggregation in Zebrafish (Danio rerio) Parkinson's Disease Model

  Faisal A. Muslikh, Zulvikar S. Ulhaq, Suko Hardjono, Mangestuti Agil

  4143 – 4147

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  Effect of Annona muricata L. (Soursop) on Blood Glucose Level in a Diabetic Rat Model: A Meta-Analysis

  Rahmad Darmawan, Ira Humairah, Ema Qunianingsih, Ervi A. Munthe, Linda

  4148 – 4154

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  Evaluation of the Antidiabetic Efficacy of Indigenous Indonesian Ethnomedicinal Herbal Infusions in a Streptozotocin-induced Diabetic Mouse Model

  Mally G. Sholih, Munir A. Mulki, Marsah R. Utami

  4155 – 4161

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  Synergistic Effects of the Combination of Active Fractions of Red Ginger Rhizome (Zingiber officinale var. rubrum) with Doxorubicin on 4T1 Cells

  Nadia D. Oktaviani , Maryati Maryati

  4162 – 4166

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  Tenofovir/Cyanovirin-N Hydrogel Formulations: An Investigation Into Rheology, Drug Release Kinetics and Mucoadhesive Properties

  Karamot O. Oyediran, Ibilola M. Cardoso-Daodu, Peace-Ofonabasi O. Bassey, Deborah A. Ogundemuren, Chukwuemeka P. Azubuike, Rachna Agarwal, Kondoru Haritha, Margaret. O. Ilomuanya

  4167 – 4181

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  Calcium-Based Nutraceutical Strategy to Reverse Aging-Associated Organ Injury

  Abidemi T. Eludire, Aniebiet U. Essien, Emmanuel O. Odungide, Damilola O. Peters, Israel S. Afolabi

  4182 – 4200

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  Coenzyme Q10 Mitigates Hepatocellular Damage in Fructose-Fed Streptozotocin-Induced Diabetic Rats via Decrease in Oxidative-stress, Inflammation, and Modulation of Key Pathways

  Akinwunmi O. Adeoye, Jude Akinyelu, Daniela J. Porta, John A. Falode, María A. Rivoira, Néstor H. Garcia

  4201 – 4213

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  Antioxidant, Antibacterial and Antifungal Activities of Black Ginger Essential Oils in Vietnam

  Quang Huy Nguyen, Van Phuong Nguyen, Thi Van Anh Nguyen, Hong Luyen Le

  4214 – 4219

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  Traditional Treatment For Postpartum Performed By The Dayak Tribe In Pasti Jaya Village, Samalantan District, Bengkayang Regency

  Ruqiah G. P. Panjaitan, Wiwik Hartika, Andi B Tenriawaru, Budi Irawan, Zhou Gui

  4220 – 4227

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  Tumor-infiltrating Foxp3+ Regulatory T Cells Contribute to Partial EMT through the Snail+ Tumor Cell Feedback Loop in Nasopharyngeal Carcinoma Patients

  Yenita Yenita, Efrida Efrida, Daan Khambri, Tofrizal Tofrizal, Aisyah Elliyanti

  4228 – 4234

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  Phaleria Macrocarpa Extract Reduced Endometriosis Lesions by Regulating Inflammatory Protein and Inhibiting Ki67 and Vegf-A Protein

  Maharani Maharani, Sutrisno Sutrisno, Sri Winarsih, Agustina Tri Endharti, I Wayan Arsana Wiyasa, Husnul Khotimah, I Wayan Agung Indrawan, Hendy Hendarto

  4235 – 4241

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  In Silico Study of Green Tea and Green Coffee Compounds Inhibiting Cardiac Fibrosis in Metabolic Syndrome Via Dual Inhibition FGF23/FGFR4

  Victor A. Hose, Mohammad S. Rohman, Indah N. Chomsy, Dian Nugrahenny

  4242 – 4249

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  Dose-Response Evaluation of Blumea balsamifera Leaf Ethanol Extract in Acute and Subchronic Toxicity Models in Mice for Sustainable Application

  Bui H. Quan, Tran T. P. Nhung

  4250 – 4259

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  Physicochemical Assessment and Evaluation of Antibacterial and Antioxidant Activity of Madecassoside Gels

  Shu X Chong, Dorothy SQ Aow, Yu J Ho, Wei T Sze, Lee H Chia

  4260 – 4272

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  Potential of Nano Phyllanthus niruri L. as Anti-DENV Candidate

  Marshanda P. Maharani, Maulidah Tsalsabila, Dwiyanti R. Fajriyah, Teguh H. Sucipto, Tukiran, Andika P. Wardana

  4273 – 4278

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  The Antioxidant Activity of Muntingia calabura L. Leaf Extract and its Effect in Acute Gout Arthritis Rat Model: Reactive Oxygen Species Modulation

  Nita Parisa, Lazahra Salsabiltha, Ayeshah A. Rosdah, Syarinta Adenina, Veny Larasati, Bintang A. Prananjaya, Theodorus

  4279 – 4284

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  Metabolomics-Guided Discovery of Anticancer Metabolites from Marine Sponge-Associated Bacillus safensis: In Vitro and In Silico Evaluation

  Muhammad F. Falakh, Ummu M. Zuhri, Febriana Untari, Tutik Murniasih, Fauzy Rachman, Ruby Setiawan, Joko T. Wibowo, Triana Hertiani

  4285 – 4296

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  Biocompatibility of Acemannan Paste as A Root Canal Filler and Its Antibacterial Activity against Enterococcus faecalis in Rat Teeth Model

  Yuli Nugraeni, Rachmavidianti, Wibi Riawan, Kristina Puspo, Regitha D. Bestari, Nathanael F. Nuralim

  4297 – 4303

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  Chemical Composition and Anti-Inflammatory Activity of Essential Oils from Piper betle Leaves Growing in Vietnam

  Pham T. H. Minh, Vu T. Ha, Hoang T. Bich, Dinh T. T. Thuy, Pham M. Quan, Vu T. Dat, Nguyen T. Hue, Nguyen N. Linh, Nguyen T. Tuan, Do T. Lam

  4304 – 4309

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  Potential of Ganoderma applanatum Extract as Anticancer and Immunomodulator in Diethylnitrosamine-induced Colon Cancer

  Siti Rahayu, Aulia Umi Rohmatika, Ufairanisa Islamatasya, Mochammad Aqilah Herdiansyah, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, Djoko Santoso, Odi Yoshitaka Anggarda, Sri Puji Astuti Wahyuningsih, Win Darmanto

  4310 – 4320

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  Chemical Composition of Plectranthus amboinicus Leaf Essential Oil from Phetchabun, Thailand, and Its Potential to Combat Enteropathogenic Bacteria and Regulate Blood Pressure

  Wansuda Sutinan, Nanthawan Reuk-ngam, Panita Khlaychan, Nitirat Chimnoi, Phonchanok Reuk-ngam, Supanna Techasakul

  4321 – 4330

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  Optimization of Microwave - Assisted Extraction Conditions for Total Saponin Content and Antioxidant Activity of Launaea sarmentosa Leaves

  Thu M. Tran, Huyen T. Nguyen, Giang T.T. Dinh, Tai T. Tran, Quang D. Ho, Thang C. Truong, Khanh K. Nguyen, Kieu P. Nguyen, Tuan N. Nguyen, Thanh T. Nguyen

  4331 – 4335

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  Antibacterial Activity of Melastoma malabathricum L. Leaves and Efficacy in Liquid Spray Formulation against Acne-Causing Bacteria (Staphylococcus epidermidis)

  Rizky Y. Putra, Gesit Ayuningtyas, Ruri P. Mariska, Santi Perawati, Lili Andriani, Priyambodo, Asep Muhamad Ridwanuloh, Dwi Wulandari, Rina Isnawati, Siti Hamidatul Aliyah

  4336 – 4342

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  Metabolite Profiling of the Ethanol and Ethyl Acetate Extracts of Ulva lactuca using UPLC-QToF-MS/MS

  Intan K Prasetyanti, Amitasari Damayanti

  4343 – 4352

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  The Stimulatory Effect of Porcine Placenta Extract on in Vitro Biological Activities of Keratinocytes and Fibroblasts

  Chatchai  Nensat , Worawat  Songjang, Jeranan  Inpad, Nutthamon  Kijchalao, Rutaiwan  Tohtong, Tuangporn  Suthiphongchai, Suchada  Pimsen, Panthip  Rattanasinganchan, Pornphimon  Metheenukul, Tavan  Janvilisri, Penpak  Moolthiya, Kittipat  Sopitthummakhun, Arunya  Jiraviriyakul

  4353 – 4360

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  Integration of Bioinformatics and Pharmacological Network for Exploring the Potential of Curcumin as a Herbal Medicine for Adenomyosis

  Nastiti H. Mayangsari, Darmawi  Darmawi, Muhammad Yusuf, S. Donel, Wiwin  Suhandri, Wirawan Adikusuma, Suyanto Suyanto, Neni Frimayanti, Rifia T. Fani

  4361 – 4368

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  Protective Potential of Garcinia Cowa Roxb Fruit Peel Extract Against UVB-Induced Skin Damage in Rattus norvegicus Rats

  Prima Minerva, Riesye  Arisanty, Rinita  Amelia, Shinta Ayu Intan, Maida Wilis

  4369 – 4375

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  Comparison of Saffron (crocus sativus l.) and Atorvastatin for Anti-dyslipidaemic and Anti-Oxidant Effects in Dyslipidaemia Male Rat Models

  Fadhilah Arsyil, Gwenny I. Prabowo, Purwo S. Rejeki, Arlinda S. Prameswari

  4376 – 4382

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  Modulation of Erythroid and Immune Cell Markers by Vitamin D and Tinospora cordifolia in infected Mice

  Poncojari  Wahyono, Helmin Trianita, Muhammad A. Muchlisin, Husamah, Ahmad S. Jamil

  4383 – 4397

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  Ethnoveterinary Medicine in Si Somdet District, Roi Et Province, Northeastern Thailand: An Alternative Approach to Animal Healthcare

  Piyaporn  Saensouk, Surapon  Saensouk, Thawatphong  Boonma, Auemporn  Junsongduang, Khamfa Chanthavongsa, Sasithorn Sachaiyan, Tammanoon Jitpromma

  4388 – 4399

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  In Silico Molecular Docking Of Beta-Sitosterol and Astaxanthin into Cyclooxygenase Enzymes

  Aqilatul R. A. Rahim, Muhammad I. Bashir, Zalina Zahari, Umar I. Ibrahim, Nureen F. M. Soufi, Nur I. Rosli, Mohamad H. N. Zainuddin

  4400 – 4417

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  Prevalence, Antimicrobial Resistance, and Phylogenetic Characterization of Esbl-Producing Escherichia Coli Isolated from Clinical Specimens in Can Tho, Vietnam

  Nga TN. Pham, Ngan TK. Nguyen, Minh Q. Huynh, Son T. Le

  4418 – 4423

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  Phytochemical Characterization and Neuroprotective Potential of Ruta chalepensis Essential Oil via Cholinesterase Inhibition

  Arwa R. Althaher, Hala M.  Qawass, Wan Mohd Nuzul H. Wan Salleh

  4424 – 4427

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  Quantification of Protocatechuic Acid in Hibiscus sabdariffa Collected in Vietnam by HPLC-PDA

  Pham T. Phuong, Nguyen T. H. Tuan, Nguyen H. Ngan, Trinh V. Lam, Vu N. Thang

  4428 – 4435

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  Integrative Network Pharmacology and Molecular Docking Analysis of Uncaria gambir Roxb. Against MCF-7 Human Breast Cancer Cells

  Nur Hasanah, Nanang Yunarto, Nurwulan A. Ismaya 

  4436 – 4443

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  Structure-Based Discovery of Immunomodulators for Stunting Inspired by Caulerpin: A Rational Approach Targeting Immune Homeostasis

  Jelita S.H. Hinonaung, Yeanneke L. Tinungki, Walter Balansa

  4444 – 4459

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  Network Pharmacology-Based Prediction of the Mechanism of Anti-Hepatitis C Virus of Kleinhovia Hospita L

  Muhammad Arba, Sunandar Ihsan, Milba N. Mazida, Jamili Jamili, Tutik S. Wahyuni

  4460 – 4467

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  Clinical and Biological Efficacy of Jin-La-Wan Herbal Oil Formulation for the Treatment of Pressure Ulcers: A Randomized Controlled Trial

  Thanyaluck  Siriyong, Pimyot Vipoosanapat, Pattaraporn Bunmee, Chula Viriyabuppa, Chadchom Choockong, Supayang Piyawan Voravuthikunchai

  4468 – 4475

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  Phytochemical Profiling of Limau Kuit (Citrus jambhiri Lush.) using FTIR Spectroscopy and Multivariate Analysis

  Kasman Kasman, Hasanuddin Ishak, Gemini Alam, Ridwan Amiruddin, Poedji Hastutiek, Andi A. Arsin, Isra Wahid, Sudirman Nasir, Muhammad Raihan, Antoni Pardede, Anwar Mallongi

  4476 – 4483

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  Greener Cultivation: Replacing Man Rogosa and Sharpe Agar with Beetroot and Soybean-Formulated Medium for Lactic Acid Bacteria Cultivation

  Belhadj O. Kamel, Sahnouni Fatima, Hariri Ahmed

  4484 – 4494

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  Protective Effects of Peperomia pellucida Extract Against Secondhand Smoke-Induced Pulmonary Fibrosis via Antioxidant and Anti-inflammatory Pathways

  Johanes AF Kristijanto, Viky N Zahiroh, Anang Triadi, Nur Khamidah, Farida A Soetedjo

  4495 – 4502

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  Modulation of Cytokine Imbalance by Phaleria macrocarpa Leaf Extract in LPS-stimulated RAW 264.7 Macrophages

  Assa'idatus Shofiah, Yuyun I. Christina, Dinia R. Dwijayanti, Aries Soewondo, Nashi Widodo, Muhammad S. Djati

  4503 – 4508

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  Development and Characterization of Halal Excipient Co-Processed Jackfruit Seed Starch (Artocarpus Heterophyllus Lam.) and HPMC K15

  Mayu Rahmayanti, Lumen M Septianshar, Tanaya J Dewi, Rahayu H Nikmah, Ginanjar P Nastiti

  4509 – 4516

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  Decaffeinated Green Tea and Green Coffee Extract Attenuate Cardiac Perivascular Fibrosis in a Metabolic Syndrome Model by Decreasing Fibroblast Growth Factor 23 and Runt-related transcription factor 2 Expression

  Mohammad S. Rohman, Victor A.G. Hose, Dian Nugrahenny

  4517 – 4523

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  Evaluating the Anti-Hyperuricemic Activity of the Ethanol Extract of Leucas Lavandulaefolia in Wistar Rats

  Muharni Muharni, Annisa Amriani, Annisa M Anatasya, Heni Yohandini, Ferlinahayati, Poedji L Hariani

  4524 – 4528

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  Optimization of Polyphenol Extraction from Two Ziziphus Species via Central Composite Design-Response Surface Methodology: In Vitro Screening for Antioxidant, Antidiabetic, and Anti-Glycation Potentials

  Maged Alkanad, Nischit S. Shankar, Ghada Alhamdani, Annegowda H. Venkatappa

  4529 – 4537

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  Inhibition of Hyperpigmentation by Padina australis Hauck on B16F10 Melanoma Cells In Vitro and Emulgel Formulation

  Wirasti Wirasti, Retno Murwanti, Nanang Fakhrudin, Erna P Setyowati

  4538 – 4545

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  Therapeutic Potential of Lactobacillus plantarum DS1 in Modulating Hypertension, Blood Sugar and Inflammation via ACE-2 Expression in Diabetic Rats

  Dessy Abdullah, Nadia Purnama Dewi, Yudha Endra Pratama

  4546 – 4552

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  Anticancer Activity of Combined Extracts of Sappan Wood (Caesalpinia sappan L.) and Coffee Stem Parasite (Loranthus ferrugineus Roxb) Against MCF7 Breast Cancer Cells Through In Silico and In Vitro Approaches

  Tita Juwitaningsih, Destria Roza, Eddiyanto Eddiyanto, Murniaty Simorangkir, Dwi Sapri Ramadhan, Yaya Rukayadi

  4553 – 4562

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  Deciphering the protective efficacy of Portulaca quadrifida extract in Mitigating Cisplatin-Induced Oxidative Hepatotoxicity: Correlative in vivo and in silico analyses

  Geetha Subramaniam, Helan S. Rani Michael, Aswini Anguraj, Ranjithkumar Rajamani, Shivakumar Bandhumy Lingam, Rathish Kumar Sivaraman, Dinesh K.P. Bheeman

  4563 – 4574

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  Study of the Antioxidant and Antidiabetic Properties of the Alga Halopteris Scoparia: In Vitro and In Vivo Evaluation in Alloxan-Induced Diabetic Mice

  Laabar Abdelmounaim, Imad Kabach, Soufiane Drioua, Bitwell Chibuye, Azzouz Krid, Ayoub El Hamri, Hicham Dahak, Hicham Bouchahta, Moulay E. Faouzi

  4575 – 4585

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  Bioactive Potential of Pistacia terebinthus L. From the Atlas of Morrocco: Antioxidant and Antimicrobial Properties

  Mohammed Bassouya, Mohamed Chedadi, Jawhari Fatima Zahra, Khalid Chebbac, Abdelfattah El Moussaoui, Amina Bari

  4588 – 4600

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  Phytochemical Profile, Antioxidant Potential, and Hemolytic Safety of Tecoma stans (L.) Kunth Leaf and Flower Extracts Using Different Solvents

  Sujira Maneerat, Pontita Siribut, Charinya So-In, Phitcharat Sunthamala, Surasak Khankhum, Nuchsupha Sunthamala

  4601 – 4606

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  Antibacterial activity of Gel Nanohydroxyapatite-abalone as Remineralization Agent against Lactobacillus acidophilus, Streptococcus sanguinis, and Streptococcus mutans

  Mona Sari, Supardi, Heru Kuswanto, Rita Prasetyowati, Kuncoro A. Nugroho, Wipsar S.B. Dwandaru, Yusril Yusuf

  4607 – 4611

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  The Potential of Cocos nucifera Endocarp Carbon as an Adjunctive Root Canal Irrigant for Dentin Protection and Antibacterial Effects

  Nur Asmah, Siti Maisarah, Erna Irawati, Mila Febriany

  4612 – 4620

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  Molecular Docking Study of Standardized Lime (Citrus aurantiifolia) Peel Decoction as an Antidiabetic Herbal

  Yesi Desmiaty, Francis Xavier, Hanifah Agusti, Senjanursa Senjanursa, Inggit Bala, Sahroni Sahroni, Sy S. Arini, Natalie Nastasja, Esti Mumpuni, Esti Mulatsari, Andri Prasetyo

  4621 – 4628

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  Chemical profiling and pharmacological properties of Arbutus unedo L. collected from Morocco

  Fatine Belfekih, Ahmed Moussaif , Mohamed Bnouham, Amal Elrherabi, Rhizlan Abdnim, Mohammed El Hassouni, Walid Guerrab, Abderrazzak El Moutaouakil Ala Allah, Laila Benbacer, Abdelghani Iddar, Rachid Bengueddour, Mohammed El Mzibri

  4629 – 4640

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  Curcuma longa Extract Attenuates Pentylenetetrazole-Induced Neurotoxicity in the Cerebral Cortex of Wistar Rats: Evidence for Neuroprotective Effect

  Hasiya S. Buba, Abubakar M. Bello, Luqman A. Hassan, Fatsuma B. Jajere, Foluso O. Ojo, Ibrahim Bunu

  4641 – 4644

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  Anti-stress Potential of Ethanol Leaf Extracts of Parquetina and Common Figs in Chronic Forced Swim Stress

  Ayokunmi A. Akinduko, Sule O Salawu, Afolabi C Akinmoladun, Afolabi A Akindahunsi

  4645 – 4650

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  Toxicity and Protective Effects of Biosulforaphane against Aspergillus fumigatus

  Ikechukwu H. Iheukwumere, Anthony K. Nwankwo, Chidiogo M. Iheukwumere, Bright C. Unaeze, Amaka O. Obianom, Nnenna N. Onyemekara, Henry C. Nnadozie, Valentine C. Unegbu, Nkemalolam A. Okorie, Catherine N. Dim, Anthony O. Ekesiobi, Chinwe E. Ejike, Chukwuebuka Egbuna

  4651 – 4658

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  Behavioural, Biochemical, and Cerebral Histomorphological Effects of Aqueous Extract of Datura stramonium L. Leaves in Rats

  Joshua Falade, Olakunle J. Onaolapo, Adejoke Y. Onaolapo, Foluso O. Ojo

  4658 – 4669

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