Effect of Annona muricata L. (Soursop) on Blood Glucose Level in a Diabetic Rat Model: A Meta-Analysis
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Abstract
Annona muricata L. (soursop) is a plant rich in bioactive compounds and has been extensively studied for its potential antidiabetic and antioxidant properties. However, findings across studies have been inconsistent regarding its efficacy. This meta-analysis aims to synthesize and evaluate the available scientific evidence to draw reliable conclusions about the effectiveness and underlying mechanisms of A. muricata in managing diabetes mellitus. Relevant studies were retrieved from three major scientific databases: PubMed, Scopus, and Web of Science. The analysis included studies that reported blood glucose levels in diabetic rodent models treated with A. muricata extract. Statistical analysis revealed that supplementation with A. muricata extract significantly reduced blood glucose levels (SMD = –7.05; 95% CI: –11.22 to –4.61; p < 0.00001) in diabetic rats compared to control groups. These findings indicate that A. muricata has a significant hypoglycemic effect and holds promise as a potential therapeutic agent for diabetes management.
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