Calcium-Based Nutraceutical Strategy to Reverse Aging-Associated Organ Injury

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Published: 2025-09-30
DOI: https://doi.org/10.26538/tjnpr/v9i9.15
Keywords:
Aging, Micronutrient supplement, Organ injury, Healing, Diet, Calcium

Main Article Content

Abidemi T. Eludire
Department of Biochemistry, Covenant University, P.M.B 1023, Km 10, Idiroko Road, Canaan land, Ota, Ogun State, Nigeria
Aniebiet U. Essien
Department of Biochemistry, Covenant University, P.M.B 1023, Km 10, Idiroko Road, Canaan land, Ota, Ogun State, Nigeria
Emmanuel O. Odungide
Department of Biochemistry, Covenant University, P.M.B 1023, Km 10, Idiroko Road, Canaan land, Ota, Ogun State, Nigeria
Damilola O. Peters
Department of Biochemistry, Covenant University, P.M.B 1023, Km 10, Idiroko Road, Canaan land, Ota, Ogun State, Nigeria
Israel S. Afolabi
Department of Biochemistry, Covenant University, P.M.B 1023, Km 10, Idiroko Road, Canaan land, Ota, Ogun State, Nigeria

Abstract

Calcium is an essential nutrient that affects cellular communication. This study aimed to investigate the protective and therapeutic effects of calcium-based diets on organ integrity in female rats exposed to excess monosodium glutamate (MSG). Female Wistar rats were divided into five groups of nine rats each, pre-fed in one phase and post-fed in another phase with calcium-based diets; calcium lactate (9.2 µL/g body weight) and calcium-D-glucarate (CDG, 35 mg/kg body weight), along with their combination (calcium lactate and calcium-D-glucarate) before and after the intraperitoneal administration of excess monosodium glutamate MSG (750 mg/kg body weight) for 70 days. Serum, liver, and small intestinal biochemical parameters were measured at 14, 28, and 42 days using Enzyme-linked Immunosorbent Assay (ELISA) and spectrophotometric techniques. The effects of calcium-based treatment on the organ integrity were also evaluated by histological examination. The 14-day pre-administered calcium diet, 28-day individually pre-administered calcium-D-glucarate (CDG), and 14-day post-administered combined diets (calcium and calcium-D-glucarate) significantly (p<0.05) reduced serum alanine transferase activities and estrogen levels. The pre-treated and post-administered calcium-D-glucarate (CDG) significantly (p<0.05) reduced β-glucuronidase activity. Additionally, pre-administered calcium lactate and the combined diet calcium and calcium-D-glucarate significantly (p<0.05) reduced lactate dehydrogenase (LDH) activity. However, post-administered calcium diet and calcium-D-glucarate (CDG) significantly (p<0.05) increased lactate dehydrogenase LDH activity during the first 28 days. The calcium and calcium-D-glucarate (CDG) diets histologically exhibited differential capacities to restore the integrity of damaged organs. These findings therefore suggest that calcium lactate and calcium-D-glucarate (CDG) supplementation are effective strategies for managing organ damage and age-related conditions.

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Vol. 9 No. 9 (2025): Tropical Journal of Natural Product Research (TJNPR)

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How to Cite

Calcium-Based Nutraceutical Strategy to Reverse Aging-Associated Organ Injury. (2025). Tropical Journal of Natural Product Research , 9(9), 4182 – 4200. https://doi.org/10.26538/tjnpr/v9i9.15

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