Vol. 9 No. 1 (2025): Tropical Journal of Natural Product Research (TJNPR) | Tropical Journal of Natural Product Research (TJNPR)

Assessment of Heavy Metals Content in Edible Vegetable of Kangkung (Ipomaea) Grown on Tondano Sediments-Based Fly Ash Bottom Ash (FABA) Mixtures

Meldi T. M. Sinolungan, Zetly E. Tamod, Wiesje J. N. Kumolontang, Yani E. B. Kamagi

1 - 6

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DOI: https://doi.org/10.26538/tjnpr/v9i1.1

Structural Analysis of Saponin Isolate from the Soapbark Tree Extract

Paul C. Adiukwu, Motshegwana O. Tebogo, Florah Moshapa, Deepthi Rapaka, Veera R. Bitra, Patience U. Tweteise

7-13

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DOI: https://doi.org/10.26538/tjnpr/v9i1.2

Evaluation of Antimicrobial and Sporicidal Activities, and Stability Testing of Herbal Skin Wash Preparations from Melaleuca cajuputi subsp. cumingiana Essential Oils and Kyllinga nemoralis Aqueous Extract

Noor Zarina Abd Wahab, Siti Nur Aliah Noor Azam, Sayed Mohd Saufi Fahmi Sayed Abdul Kadir, Mohd Hanif Abdullah

14 - 23

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DOI: https://doi.org/10.26538/tjnpr/v9i1.3

The Potency of Adenostemma platyphyllum and A. madurense as Antioxidant and Anti-aging Agents

Ahmad A. Rofiqi, Rika I. Astuti, Irmanida Batubara

24 - 30

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DOI: https://doi.org/10.26538/tjnpr/v9i1.4

Antioxidant, Lipase Inhibitory Potential, and UHPLC Profile of Different Fractions of Moringa oleifera Leaves

Hasim Hasim, Fitra Tunnisa, Didah N Faridah, Saraswati Saraswati, Fitria Slameut

31 - 36

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DOI: https://doi.org/10.26538/tjnpr/v9i1.5

Antimycobacterial and Gas Chromatography-Mass Spectrometry Profiles of Cassia auriculata, Hallea stipulosa, Euphorbia nyikae, and Albizia anthelmintica

Ramadhani S. O. Nondo, Francis Machumi, Imani A. Kikoti, Michael Qwarse, Alfredi A. Moyo, Alphonce I. Marealle, Boniphace C. Mwita, Aneth Kavuraya, Pax J. Masimba, Mainen J. Moshi

37 - 43

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DOI: https://doi.org/10.26538/tjnpr/v9i1.6

Exploring Artemisia judaica subsp. sahariensis (L. Chevall.) Maire, from Tamanrasset: Antioxidant and Antispasmodic Properties of an Endemic Species of the Algerian Sahara

Sihem Belkhiter, Nabahat Benmansour, Soumia Atchi, Rima Arab, Sabrine Boudjella

44 - 49

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DOI: https://doi.org/10.26538/tjnpr/v9i1.7

The Effect of a High-Whey Protein Diet Combined With Lactobacillus acidophilus on Insulin Resistance, Intestinal Microbiota, and the Histology of the Liver, Spleen, Kidneys, and Colon

Aicha Sbaihia, Bouasria Benbouziane, Soumia Keddari, Mohamed C. Bentahar, Hiba Fedal

50 - 57

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DOI: https://doi.org/10.26538/tjnpr/v9i1.8

Cytotoxicity and Anticancer Potentials of Secondary Metabolites of Soil Actinobacteria Isolated from Soraya Research Station, Gunung Leuser National Park, Aceh

Fauziah Fauziah, Yekki Yasmin, Binawati Ginting, Khairan Khairan, Suci Fildzati, Putri Yasmin, Lenni Fitri

58 - 66

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DOI: https://doi.org/10.26538/tjnpr/v9i1.9

Enhancing Chemotherapeutic Efficacy: Synergistic Cytotoxic Effect of Garcinia cowa Bark Extract and Doxorubicin in T47D Breast Cancer Cells

Ifora Ifora, Dachriyanus Hamidi, Meri Susanti, Dira Hefni, Fatma S. Wahyuni

67 - 72

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DOI: https://doi.org/10.26538/tjnpr/v9i1.10

Optimization of Extraction Condition and the Antioxidant Activity of Momordica charantia Leaves from Vietnam

Kieu P. Nguyen, Huyen T. Nguyen, Xuan TT. Dao, Khanh K. Nguyen, Tuan N. Nguyen, Thanh T. Nguyen

73 - 78

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DOI: https://doi.org/10.26538/tjnpr/v9i1.11

Argan Oil Mitigates Oxidative Stress Induced by Chronic Alcohol Consumption in Rats: An In Vivo and In Silico Study with Computational ADMET and Molecular Docking Analysis

Ayoub Bekkouch, Hicham Mostafi, Amine Elbouzidi, Oussama Bekkouch, Abdellah Baraich, Nour E. Bentouhami, Anas Ziani, Mohammed Merzouki, Mohamed Addi, Allal Challioui, Aboubaker El Hesni, Abdelhalem Mesfioui

79 - 89

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DOI: https://doi.org/10.26538/tjnpr/v9i1.12

Green Synthesized Zinc Oxide Nanoparticles from Coffea arabica: Bioprospecting and Functional Potential as an Antioxidant and Larvicidal Agent against Aedes aegypti

Sulastri, Ahyar Ahmad, Abdul Karim, Isra Wahid, Wahyudin Rauf, Harningsih Karim, Andi M. Farid

90 - 96

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DOI: https://doi.org/10.26538/tjnpr/v9i1.13

Antibacterial and Antibiofilm Properties of Jicama (Pachyrhizus erosus) Seed Extract against Streptococcus mutans: Identification of Key Bioactive Compounds Using Bioautography and LC-MS/MS Analysis

Min Rahminiwati, Irmanida Batubara, Waras Nurcholis, Raden R. Safinatunajah, Fitria E. Sari, Fitria D. Sulistiyono

97 - 103

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DOI: https://doi.org/10.26538/tjnpr/v9i1.14

Molecular Identification Using DNA Barcoding and Phytochemical Profiling in Four Basil (Ocimum spp.) from Different Locations in Bali

I G.D. Wirawan, Shara Y. Harianja, I. K. Suada, I G. K. Susrama, Anak A. K. Krisnandika, I G. N. A. S. Wirawan, Anak A. A. Mirahadi, Maria M. V. Sasadara

104 - 111

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DOI: https://doi.org/10.26538/tjnpr/v9i1.15

Delayed Tissue Fixation for as Short as Five Minutes Can Distort Tissue Architecture and Falsify Research Results

Ugochukwu S. Aguwa, Roseline Ogwo, Chijioke Evaristus, Darlington N. Onyejike, Uche D. Abazuh

112-118

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DOI: https://doi.org/10.26538/tjnpr/v9i1.16

Effect of pH Variation of Ethanol Solvent in Purple Sweet Potato (Ipomoea batatas L.) Extract on Hepatoprotective Activity of White Rats (Rattus novergicus)

Mochamad H. Nurzaman, Salsabila Adlina, Aditya Kuncoro, Nitya N. Fadilah, Taufik Hidayat

119-122

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DOI: https://doi.org/10.26538/tjnpr/v9i1.17

Phytochemical Constituents of Justicia carnea Leaves and their Antibacterial Activity

Ikechukwu K. Ijoma, Joy C. Anosike, Chisom Onwuka, Ambrose N. Njokunwogbu, Vincent I.E. Ajiwe

123-127

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DOI: https://doi.org/10.26538/tjnpr/v9i1.18

Hypoxia-Induced Mesenchymal Stem Cell Secretome Enhances IL-10 via STAT3 Pathway in a Rat PCOS Model

Lusiana Lusiana, Dewi M. Darlan, Setyo Trisnadi, Agung Putra, Titiek Sumarawati, Chodijah Chodijah, Nur D. Amalina

128-133

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DOI: https://doi.org/10.26538/tjnpr/v9i1.19

Nutritional and Bioactive Properties of Arbutus unedo, Myrtus communis, and Lavandula stoechas: Implications for Functional Foods

Nisserine El Hammadi, Bahia Abdelfattah, Amena Mrabet, Mohamed Khaddor

134-142

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DOI: https://doi.org/10.26538/tjnpr/v9i1.20

Genotyping and Phytochemical Analysis of Three Species of Spider Lily (Hymenocallis spp.)

Putu Merteyasa, I G. P. Wirawan, Trisna A. Phabiola, I K. Suada, I N. Wijaya, Ketut A. Yuliadhi, I G. N. A. S. Wirawan, Maria M.V. Sasadara

143-151

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DOI: https://doi.org/10.26538/tjnpr/v9i1.21

Enhancement of Aceclofenac Dissolution Rate via Solid Dispersion with Hydroxypropyl Methylcellulose

Doddy Rusli, Salman Umar, Yufri Aldi, Hendrizal Usman, Muhammad N Siregar, Erizal Zaini

152-156

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DOI: https://doi.org/10.26538/tjnpr/v9i1.22

In Silico Screening of Laminaria japonica Ligands as Potential Inhibitors of DPP-4 for Type 2 Diabetes Treatment

Ellin Febrina, Putri Regina, Yasmiwar Susilawati, Ferry F. Sofian, Aiyi Asnawi

157-167

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DOI: https://doi.org/10.26538/tjnpr/v9i1.23

Biopolymer Nanoencapsulation of Andrographis paniculata (Burm. f.) Nees and Carboxymethyl Chitosan for Dengue Therapy

Browi Nugroho, Sari E. Cahyaningrum, Pirim Setiarso, Andika P. Wardana, Teguh H. Sucipto

168-175

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DOI: https://doi.org/10.26538/tjnpr/v9i1.24

Nephroprotective Effect of Ethyl Acetate Fraction of Cogongrass (Imperata cylindrica) Root Acute Kidney Injury

Widya M Rahmawati, Okid P Astirin, Widya M Rahmawati

176-182

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DOI: https://doi.org/10.26538/tjnpr/v9i1.25

Physicochemical Characteristics of Asian Moon Scallop Shell as a Tooth Remineralization Agent

Dewi M. Ramadhanti, Arlina Nurhapsari, Yayun S. Rochmah

183-188

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DOI: https://doi.org/10.26538/tjnpr/v9i1.26

Optimization of Solvent Mixtures and Maceration Method Using Simplex Centroid Design for Phenolic Extraction and Radical Scavenging Activity in Amomum compactum Fruit

Waras Nurcholis, Revita Istigfiani, Marlin, Bambang P. Priosoeryanto

189-193

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DOI: https://doi.org/10.26538/tjnpr/v9i1.27

Ziziphus mauritiana in Triple-Negative Breast Cancer: Integrating Network Pharmacology and In Vitro Evaluation

Dian Y. Lestari, Gondo Mastutik, Indri S. Mukono

194-199

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DOI: https://doi.org/10.26538/tjnpr/v9i1.28

Biological Resource and Traditional Uses of the Genus Hellenia in Thailand with A New Variety from Thailand

Piyaporn Saensouk, Surapon Saensouk, Pimtida Niamngon, Sarayut Rakarcha

200 - 203

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DOI: https://doi.org/10.26538/tjnpr/v9i1.29

The Effect of Noni (Morinda citrifolia) Extract Gel on Collagen Density and Expression of p53 Protein in Rats Exposed to UVB

Wida M. Indriyana, Chodidjah Chodidjah, Titiek Sumarawati

204 - 208

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DOI: https://doi.org/10.26538/tjnpr/v9i1.30

In Vitro Inhibitory Activity of Lygodium Japonicum Leaves on Α-Amylase, Α-Glucosidase, and Dipeptidyl Peptidase-IV

Nguyen H. My, Nguyen L. K. Loan, Do H. Tan, Le G. H. Long, Tran L. P. Linh, Nguyen K. Oanh, Nguyen T. Anh, Nguyen H. Phuc, Bui T. Phong

209 - 212

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DOI: https://doi.org/10.26538/tjnpr/v9i1.31

Peel-off Emulgel Mask Formulation from Ethanol Extract of Frankincense Resin for Acne vulgaris Treatment

Erlia A. Sianipar, Angelica Avena, Yulia T. Narwati, Reynelda J. Sagala

213 - 218

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DOI: https://doi.org/10.26538/tjnpr/v9i1.32

Analysis of Active Compounds and In Silico Study of Vigna unguiculata as an Anti-Alzheimer Disease Agent

Dini S. Damayanti, Annisa Iktiarani, Andika P. Gymnastiar

219 - 228

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DOI: https://doi.org/10.26538/tjnpr/v9i1.33

Artocarpus heterophyllus Seed Oil Mitigates Oxidative Stress and Lipid Profile in Alloxan-Induced Diabetic albino rats

Christian E. Offor, Cynthia C. Agbo, Peter C. Agu, Adachukwu P. Ikeyi, Basil U. Nwali, Patrick M. Aja

229 - 234

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DOI: https://doi.org/10.26538/tjnpr/v9i1.34

Unlocking the Potential of Stink Bean Peel Extract: A Natural Solution for UVB-Induced Skin Hyperpigmentation

Cici R. Ustika, Sri Priyantini, Agung Putra, Prasetyowati Subchan, Titiek Sumarawati, Nur D. Amalina

235 - 239

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DOI: https://doi.org/10.26538/tjnpr/v9i1.35

Revealing the Potential of New Immunomodulatory Agents from Katokkon Pepper as a Native Toraja Plant

Reisky M. Tammu, Lastiar R. Sitompul, Rahel Simamora, Didik H. Utomo, Eka D. Putri

240-283

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DOI: https://doi.org/10.26538/tjnpr/v9i1.36

Safety Evaluation, High-Performance Thin Layer Chromatography Profile, Antioxidant, Antibacterial, and Anti-inflammatory Activities of Homalanthus macradenius Pax & K.Hoffm Crude Leaf Extract

Rosita C. Mabolo, Glenda Z. Doblas, Joliesa Mae S. Toledo, Reggie Y. Dela Cruz

284-294

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DOI: https://doi.org/10.26538/tjnpr/v9i1.37

Anti-Fungal Activity Prediction of Curcuma Longa and Piper belte through Molecular Docking

Marisca Evalina Gondokesumo, Muhammad Rezki Rasyak, Mansur Ibrahim

295-305

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DOI: https://doi.org/10.26538/tjnpr/v9i1.38

The Potential Effect of Propolis on Norovirus Viral Load: An Experimental Research using Balb/c Mice

Warda E. Rusdi, Soetjipto, Maria I. Lusida, Irmawan Farindra, Bambang E. Suwito, Muhammad S. Rusdi, Wilhemus D.M.R Benge, Irsandi R. Farmananda, Mahdiyah H. Hanifa, Hidayat

306-310

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DOI: https://doi.org/10.26538/tjnpr/v9i1.39

The Effects of Mulberry Leaves (Morus alba L.) Extract on Lipid Accumulation in Adipocytes 3T3-L1 Cells and in Vitro Cytotoxic Activity

Nuralih Nuralih, Dina Amalia, Siska A. Kusumastuti, Armansyah M. Harahap, Ros Sumarny

311-320

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DOI: https://doi.org/10.26538/tjnpr/v9i1.40

Enriched Facial Skin Serum Formulation Using Nanogold and Oligochitosan Particles: Optimization by Box Behnken Design

Aura Salsabila, Wisnu Widikdo, Purwantiningsih Sugita, Budi Arifin, Witta K. Restu

321-328

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DOI: https://doi.org/10.26538/tjnpr/v9i1.41

Harnessing the Ecofriendly Antifouling Potential of Agelasine Alkaloids Through MetaTox Analysis and Computational Studies

Walter Balansa, Riyanti, Kirsten H. Balansa, Novriyandi Hanif

329-340

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DOI: https://doi.org/10.26538/tjnpr/v9i1.42

Impact of Gestational Stress and Administration of Moringa oleifera Leaveson Post-Natal Reproductive Development of Male Offspring of Wistar Rats

Odochi O. Chukwu, Cordilia O. Iyare, Chinedum U. Emelike, Nwaeze G. Konyefom, Albert E. Okorocha, Ofovwe O. Ekakitie, Sylvester N. Ibekailo, Anthony C. U. Ezimah

341-347

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DOI: https://doi.org/10.26538/tjnpr/v9i1.43

Antihyperglycemic Activity, Total Phenolic, and Total Flavonoid Contents of 96% Ethanol Extract of Pisang Batu (Musa balbisiana Colla) Leaves

Riskianto, Andriyani, Sri W Munthe, Jessica Novia, Sutan A. Dillak, Tania Jayanti, Sem M. Laksana, Anggelina J. Langi, Zefanya Pattiradjawane, Ferawati Sihotang

348-354

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DOI: https://doi.org/10.26538/tjnpr/v9i1.44

Ameliorative potentials of Linum usitatissimum (Linn) (Flax seed) Crude Extract Against Lead Acetate-induced Neuronal Damage on the Hippocampal Histoarchitecture Using Wistar rat Model

Taiye S. Adelodun, Marvellous J. Okonoboh, Testimony P. Ajibade, Ayodeji Z. Abijo, Sunday Y. Olatunji, Ehindero S. Olorunnado, Sanmi T. Ogunsanya, Olarinde S. Adewole

355-361

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DOI: https://doi.org/10.26538/tjnpr/v9i1.45

Comprehensive Exploration of Ferulic Acid from Corn Leaves: Extraction, Structural Characterisation, HPLC Quantification, and Anti-inflammatory Evaluation through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Studies

S. Rajeshwari, Surendra K. Chowdary, A. Dileep, Suresh Joghee, Erica Alves, Bannimanth Gurupadayya, Nithin Mohan, Prashantha B. Kumar, Subba V. Madhunapantula

362-368

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DOI: https://doi.org/10.26538/tjnpr/v9i1.46