Optimization of Extraction Condition and the Antioxidant Activity of Momordica charantia Leaves from Vietnam
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Abstract
The growing interest in natural bioactive compounds has emphasized the need for efficient extraction techniques to maximize the yield of key phytochemicals. This study explores the ideal parameters, including extraction temperature, solvent concentration, and extraction duration, to optimize the extraction process and achieve maximum yields of total flavonoid content (TFC) and total phenolic content (TPC) from Momordica charantia leaves. Utilizing response surface methodology (RSM), the extraction process was optimized, revealing that the polynomial expressions for every model demonstrated significance in the obtained results. The result shows that the TPC (87.85 ± 0.24 mgGAE/g DW) and TFC (12.68 ± 0.17 mgQE/g DW) could be extracted higher in the optimum operating conditions at 72°C for 70 min and 70% ethanol concentration.
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