Artocarpus heterophyllus Seed Oil Mitigates Oxidative Stress and Lipid Profile in Alloxan-Induced Diabetic albino rats
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Abstract
Plant-based medicines have garnered attention in natural product research for years due to their potential for managing diabetic problems. In this study, rats with alloxan-induced diabetes were used to examine the effects of mineral-enriched Artocarpus heterophyllus seed oil (AhSO) on lipid profiles and redox signalling. Following chemical analysis on AhSO, 36 albino rats were divided into six groups (A-F of n=6). Group A: The typical controls received food and water. Groups B–F: One intraperitoneal injection of 100 mg/kg body weight of alloxan was used to induce diabetes. Group B, the negative control, was not given any treatment. Group C (treated with 1000 mg/kg body weight of metformin). For 28 days, groups D–F received daily dosages of AhSO at 2.5 mL/kg, 5.0 mL/kg, and 7.5 mL/kg. According to the results, the mineral compositions of AhSO were 80.34 (Ca), 79.78 (K), 62.90 (Mg), 52.87 (Na), 3.01 (Fe), 1.33 (Zn), 0.58 (P), 0.34 (Cu), and 0.13 (Mn) in decreasing order of concentration in mg/100 g. Furthermore, glutathione peroxidase (GPx), superoxide dismutase (SOD), very low-density lipoprotein (VLDL-C), catalase (CAT) activity, low-density lipoprotein (LDL-C), malondialdehyde (MDA), LDL-C (LDL-C), triglycerides, and total cholesterol were significantly (p < 0.05) lowered in treated than in untreated diabetic rats. This study proposed that AhSO may have mitigated lipid profiles and redox signaling in diabetic rats due to its enhanced mineral composition. Thus, we suggest that AhsO may be explored as a potential nutraceutical to treat diabetic conditions.
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