Tropical Journal of Natural Product Research (TJNPR)

Tropical Journal of Natural Product Research (TJNPR) is the official scientific publication of the Natural Product Research group, University of Benin; and it is available in both printed and electronic formats. The journal is published monthly.

Tropical Journal of Natural Product Research (TJNPR) is a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, papers discussing the screening of natural Product for biological activity against different health targets are also encouraged.

Vol. 9 No. 3 (2025): Tropical Journal of Natural Product Research (TJNPR)

Published: 2025-03-28

A Review of the Phytochemistry, Pharmacology and Properties of Black Tea in Health

Mikael Hovhaness, Arinda H. Sawitri, Heru Sasongko

881-895

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DOI: https://doi.org/10.26538/tjnpr/v9i3.01

The Potential of Strawberry (Fragaria ananassa) Fruit Extract in the Treatment of Hyperpigmentation: A Mini Review

Olivia J. Purnomo, Dewa A. A. S. Laksemi, I. G. N. Darmaputra

896-903

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DOI: https://doi.org/10.26538/tjnpr/v9i3.02

Chemistry and Pharmacological Properties of Morusin and Morusinol from Morus alba: An Overview

Eric W.C. Chan

904-911

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DOI: https://doi.org/10.26538/tjnpr/v9i3.03

Optimization of Formula Using D-Optimal Design Method and Stability Testing of Ascorbic Acid Transferosomes Gel

Ratih Dyah Pertiwi, Sabna A. Firti, Dara A. Putri, Hermanus E. Hurit

912-920

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DOI: https://doi.org/10.26538/tjnpr/v9i3.4

In Vitro Evaluation of Soursop Leaf (Annona muricata L) Ethanol Extract against Development and Proliferation of 4T1 Breast Cancer Cell

Ni W. Tianing, I. Wayan Sumardika, Ida AD Wiryanthini, Agung W. Indrayani, Dina Fatmawati, Gregorius W. Thongiratama, Wahyu Widyasanti

921-924

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DOI: https://doi.org/10.26538/tjnpr/v9i3.5

Antimicrobial Efficiency and Chemical Composition of Jackfruit (Artocarpus heterophyllus Lam.) Extracts from Different Plant Parts

Waraporn Sutthisa, Hathaichanok Sophachan, Piyatida Pimvichai, Nattaya Srisawad

925-932

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DOI: https://doi.org/10.26538/tjnpr/v9i3.6

Characteristics of Natural Collagen of Freshwater Snail Flesh (Pomacea paludosa) Extracted with Bromelain Enzyme and Acid-Hydro-Extraction Method

Siti Dharmawati, Aam Gunawan, Antoni Pardede, Osfar Sjofjan

933-941

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DOI: https://doi.org/10.26538/tjnpr/v9i3.7

The Effect of Avocado Seed for Socket Healing after Tooth Extraction on Diabetic Condition (In Silico and In Vivo Research)

Puspa D. Rohmaniar, Retno P. Rahayu, Ida B. Narmada, Siswandono, Anang S. Wiyono

942-949

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DOI: https://doi.org/10.26538/tjnpr/v9i3.8

Herbal Combination of Tithonia diversifolia, Moringa oleifera, and Curcuma longa as Antidiabetic Agent Against iNOS and COX-2 Proteins: An in silico Study

Nabila S. Y. Salsabila, Rif’atul H. Burhan, Moh Dliyauddin, Noviana Dwi Lestari, Aminatun Munawarti, Muhammad S. Djati, Rifa’i Muhaimin

950-959

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DOI: https://doi.org/10.26538/tjnpr/v9i3.9

Evaluation of Herbonanoceutical Formulations of Tamoenju (Hibiscus surattensis L.) Leaf Extract

Yuliet Susanto, Khildah Khaerati, Nela Sharon, Joni Tandi

960-966

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DOI: https://doi.org/10.26538/tjnpr/v9i3.10

Evaluation of Schiff Bases Against Two Cancer Cell Lines: A Combined Experimental and Theoretical Approach

Asawer S. Temma, Omar N. Ali, Rafid H. Al-Asadi, Mohammed K. Mohammed

967-972

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DOI: https://doi.org/10.26538/tjnpr/v9i3.11

Morpho-physiological parameters of Cedrus atlantica Manetti pollen discriminate genetically distinct populations of climatically different regions in the Moroccan Atlas

Codou Senghor, Saouab Fatima-Ezzahra, Mohammed Bendriss Amraoui

973-984

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DOI: https://doi.org/10.26538/tjnpr/v9i3.12

Anti-Proliferative, Anti-Inflammatory, In Vitro Wound Healing Potentials and Phenolic Content of Phlomis Crinita Cav. Extracts

Abdelhakim Chelgham, Ana borges, Ricardo C. Calhelha, Abdelaziz Merouane, Abdallah Noui, Abdelkader Saadi

985-991

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DOI: https://doi.org/10.26538/tjnpr/v9i3.13

Synergistic Cytotoxic and Cell Cycle-Regulating Effects of Garcinia cowa Leaf Extract and Trastuzumab in HER2-Positive Breast Cancer Cells

Mainal Furqan, Fatma S. Wahyuni, Meri Susanti, Dachriyanus Hamidi

992 – 1000

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DOI: https://doi.org/10.26538/tjnpr/v9i3.14

Ethanol Extract from Yellow Pumpkin Modulate Hormonal Levels and Ovarian Follicle Dynamics in Hypoestrogenic Wistar Rats

Andini D. Kinanthi, Lina N. Izza, Rohaya Muhede, Loeki E. Fitri, Kusworini Handono, Hendy S. Yudharto, Wibi Riawan, Husnul Khotimah

1001-1010

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DOI: https://doi.org/10.26538/tjnpr/v9i3.15

In silico Evaluation of the Pharmacokinetics and Toxicity Profiles of Chitosan from Haruan Fish (Channa Striata) Scale as Anti-inflammatory Agent

Deby K. T. Putri, Ashifa Q. Milyanur, Juliyatin P Utami

1011-1017

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DOI: https://doi.org/10.26538/tjnpr/v9i3.16

Potential of Cell-Free Fermentation Supernatant from Yellow Passion Fruit Microspheres as a Novel Antibacterial Agent Against Multi-Drug Resistant Organisms

Esti Hendradi, Tutiek Purwanti, Andang Miatmoko, Safarini Marwah, Isnaeni Isnaeni

1018-1024

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DOI: https://doi.org/10.26538/tjnpr/v9i3.17

Synthesis of a Novel Chemical J5 brown Dye for Staining Specific Bone Histological Sections in Green Swordtail Fish (Xiphophorus hellerii)

Jassim H. Al-Waeli, Hasanain A. Abdull-majed, Munera A. Ibrahim, Sadiq M-H. Ismael

1025-1030

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DOI: https://doi.org/10.26538/tjnpr/v9i3.18

Hepatoprotective Effect of Spondias pinnata in Isoniazid-Rifampicin-Induced Toxicity in Wistar rats

Ni Putu Aryadnyani, I Gusti A. S. M. Dewi, I Wayan P. S. Yasa, I Nyoman Wande, I Made Bakta, Rosmiati Rosmiati

1031-1037

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DOI: https://doi.org/10.26538/tjnpr/v9i3.19

Ethnobotanical and Ethnopharmacological Studies of Medicinal Plants in the Southern Mediterranean: Tangier-Tétouan Region, Northern Morocco

El-assri Youssef, El-assri El-Mehdi, Mohamed Adil Mahraz, Mounadi Idrissi Amine, Moussaoui Fatima, El Khabchi Mouna, Boukour Sara, Noureddine Eloutassi, Laglaoui Amin, Lahkimi Amal

1039-1057

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DOI: https://doi.org/10.26538/tjnpr/v9i3.20

Effect of Papaya Peel Nata Oral Administration on the Blood Glucose Level in Male Rats with Streptozotocin-Induced Diabetic Mellitus

Nur Fitriana, Ika Yustisia, Syahrijuita Kadir, Ilhamuddin Azis, Marhaen Hardjo

1058-1066

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DOI: https://doi.org/10.26538/tjnpr/v9i3.21

The Exploration of 6-Gingerol and 6-Shogaol using Network Pharmacology and Molecular Docking as Potential Inhibitors of Atherogenesis

Diana K Jasaputra, Aldrich Christiandy, Ardo Sanjaya

1067-1074

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DOI: https://doi.org/10.26538/tjnpr/v9i3.22

Secondary Metabolites from The Active Antioxidant Fraction of The Stem Bark of Syzygium zeylanicum. L. DC.

Muhammad Evan, Elfita, Ferlinahayati, Eliza, Heni Yohandini

1074-1079

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DOI: https://doi.org/10.26538/tjnpr/v9i3.23

Physicochemical Properties, Antimicrobial and Insecticidal Activities of Carvacrol: In Vitro and In Silico Toxicity Studies

Hasnae Hoummani, Ghada Beniaich, Ibrahim Mssillou, Mohamed Taibi, Meryem Idrissi Yahyaoui, Abdeslam Aseraou, Khalid Chaabane, Aimad Allali, Mohamed Chebaibi, Sanae Achour

1080 – 1088

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DOI: https://doi.org/10.26538/tjnpr/v9i3.24

Biogenic Synthesis and Characterization of Silver Nanoparticles Using a Combined Leaf Extract for Anti-Bacterial and Biofilm Inhibition Properties

Mathan Chandrasekaran, Uma Chinnaiyan, Sowndarya Sivaprakasam, Sivagurunathan Paramasivam

1089-1096

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DOI: https://doi.org/10.26538/tjnpr/v9i3.25

Insight into the Biological Activity of Zingiber officinale var. Amarum Extracts as Antioxidant and SARS-CoV-2 Inhibitor In-Silico

Rissa Laila Vifta, Sahri Yanti, Salsabiela Dwiyudrisa Suyudi, Windi Susmayanti

1097-1104

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DOI: https://doi.org/10.26538/tjnpr/v9i3.26

α-Glucosidase and xanthine oxidase inhibitory activities from the fruits of Thai Averrhoa bilimbi L.

Thuy T. L. Nguyen, Thanh Q. Tran, Lien T. M. Do, Nhat M. Huynh, Kewalin Inthanon, Jirapast Sichaem

1105 - 1111

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DOI: https://doi.org/10.26538/tjnpr/v9i3.27

Development and Standardization of an Effervescent Granule Formulation of Pomegranate Peel Extract with Potential Antioxidant Activity

Reza Pratama, Widya Nurasih, Aiyi Asnawi, Aris Suhardiman, Diki Zaelani, Muhamad Reza Pahlevi

1112 – 1117

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DOI: https://doi.org/10.26538/tjnpr/v9i3.28

Effects of Walking Exercise and Meloxicam on MMP-13 Expression and Pain Threshold in Osteoarthritis

Kusworini Handono, Dwi A. Prasetyo, Nia Kurnianingsih, Cesarius S. Wahono

1118 – 1122

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DOI: https://doi.org/10.26538/tjnpr/v9i3.29

Network Pharmacology and Molecular Docking Studies of Ethnopharmacological Plants from Sulawesi as Antidiabetics

Muhammad Sulaiman Zubair, Yonelian Yuyun, Waode Sitti Musnina, Ahmad Najib, Firzan Nainu, Muhammad Arba, Dwi Rahmi Paneo, Ersanda Nurma Praditapuspa, Saipul Maulana

1123 -1135

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DOI: https://doi.org/10.26538/tjnpr/v9i3.30

Bioassay Guided Partition of Dandang Gendis (Clinacanthus nutans L.) Monitored by Glucose Consumption Assay on Myoblast Cells and GLUT4 Molecular Docking Analysis

Mae S.H. Wahyuningsih, Saifa U. Putri, Venansi Viktaria, Dwi A.A. Nugrahaningsih, Arko J. Wicaksono

1136 – 1143

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DOI: https://doi.org/10.26538/tjnpr/v9i3.31

Synthesis and characterization of copper nanoparticles using Allium cepa (L.) outer peel at ambient temperature

Jane N. Akinniyi

1144 – 1149

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DOI: https://doi.org/10.26538/tjnpr/v9i3.32

Phytochemical Profiling and Cytotoxicity Evaluation against HeLa Cell Line of the Extract of Artocarpus elasticus Stem Bark

Andi Adi A M Naneng, Alfi H Karomah, Mohamad Rafi, Pinus Jumaryatno

1150 – 1154

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DOI: https://doi.org/10.26538/tjnpr/v9i3.33

The Effect of Apigenin from Peronema canescens on Ovarian Follicular Development in Female Albino Mice

Azzahra Ayu Sari, Almahdy, Dwisari Dillasamola

1154 – 1158

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DOI: https://doi.org/10.26538/tjnpr/v9i3.34

A comprehensive study on the biological activities of protein-rich earthworm (Perionyx excavatus) extracts collected in Vietnam

Nguyen T. Dung, Pham H. Son, Nguyen T. N. Trinh, Vo N. T. Thao, Bui B. Thinh

1159 – 1165

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DOI: https://doi.org/10.26538/tjnpr/v9i3.35

In Silico Screening of Chemical Compounds from Green Chiretta (Andrographis paniculata (Burm. F.) Nees) as Cyclooxygenase-2 Inhibitors

Dewi Yuliana, Fitrah Ayu, Ahmad Najib

1166 – 1171

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DOI: https://doi.org/10.26538/tjnpr/v9i3.36

Combination of Red Okra and Stevia Ameliorates Oxidative Stress and Inflammation in Secondhand Smoke Rats

Nurina Tyagita, Endang Mahati, Azizah H. Safitri

1172 – 1178

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DOI: https://doi.org/10.26538/tjnpr/v9i3.37

Comparison of the Metabolite Profiles of HT-29 Colorectal Cancer Cells Treated with Curcumin, Cisplatin, 5-Fluorouracil and Doxorubicin in a Metabolomic Approach

Ade Arsianti, Innas Widiasti, Aryo Tedjo, Shun Hirota, Hiroki Tanimoto

1179 – 1186

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DOI: https://doi.org/10.26538/tjnpr/v9i3.38

Identification of Potential Medicinal Plant Species in Multiflora Trigona Species Honey from Riau Using a Metabarcoding Approach

Rini Hafzari, Melva Silitonga, Eva S. Dasopang, Endang S. Gultom

1187 – 1191

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DOI: https://doi.org/10.26538/tjnpr/v9i3.39

Status of the use of naturalized medicinal plants from the Tata region (southeast of Morocco) in traditional medicine

Abdelkrim Agour, Tarik Chelouati, Mostafa Messkini, Otmane Zouirech, Abdelfattah El Moussaoui, Ibrahim Mssillou, Amina Bari, Elhoussine Derwich

1192 - 1203

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DOI: https://doi.org/10.26538/tjnpr/v9i3.40

In Vitro anti-inflammatory and antiviral activities of Pluchea indica (L.) Less. extracts on human monocytes

Neeranuch Sankla, Aphiwat Inthirach, Chayuda Sawangsay, Chalida Naewsopa, Yasunee Srisen, Charinya So-In, Surasak Khankhum, Nuchsupha Sunthamala

1204 – 1210

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DOI: https://doi.org/10.26538/tjnpr/v9i3.41

Phenolic Profile, Antioxidant Activity, and Litholytic Cholesterol Properties of Algerian Bunium incrassatum L. Extracts

Souheyla Mekraf, Mokhtaria Yasmina Boufadi, Soumia Keddari, Fatiha Abbassene, Rebbouh Farah

1211 – 1219

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DOI: https://doi.org/10.26538/tjnpr/v9i3.42

Effects of Saffron (Crocus sativus L) Compared to Atorvastatin on the Livers of Hypercholesterolemia Rat Models

Erlina K. Novitasari, Viskasari P. Kalanjati, Arlinda S. Prameswari, Nur A. Hasan, Abdurachman Abdurachman

1220 – 1227

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DOI: https://doi.org/10.26538/tjnpr/v9i3.43

Immunomodulatory effect of Artemisia vulgaris L. ethanol extract and its marker compound on antibody and cytokine release in non-immunosuppressed and immunosuppressed rats

Romauli Anna Teresia Marbun, Rosidah, Yuandani, Panal Sitorus

1228 – 1231

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DOI: https://doi.org/10.26538/tjnpr/v9i3.44

Dose and Duration of N-acetylcysteine on Superoxide Dismutase, MCP-1, and Foam Cell in Atherosclerosis Rat Model Research

Novi Haryanti, Teuku Heriansyah, Hanifah Yusuf, Mudatsir Mudatsir, Zulkarnaen Zulkarnaen

1232 – 1236

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DOI: https://doi.org/10.26538/tjnpr/v9i3.45

Peperomia pellucida Extract Enhances the Cytotoxicity of Doxorubicin against 4T1 Breast Cancer Cells

Febri Wulandari, Rauhillah N. Azizah, Yopi A. Putri

1237 – 1241

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DOI: https://doi.org/10.26538/tjnpr/v9i3.46

Effect of Methanol Extract of Launaea taraxacifolia, on Pregnancy Outcome and Some Biochemical Parameters of Rats’ Offspring

Iyabo M. Adebisi, Samson T. Joseph, Umar Mohammed

1242 – 1247

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DOI: https://doi.org/10.26538/tjnpr/v9i3.47

Phytochemical and Antiproliferative Effect of Indigofera stenophylla Guil. And Perr. (Fabaceae) Against 7,12-Dimethylbenzanthracene induced Breast Tumor in Rats

Abdulrazaq Sanusi, Muhammad K. Yahaya, Halimatu S. Hassan, Muhammad G. Magaji, Aliyu M. Musa, Taibat M. Bakare-Odunola, Ngaitad S. Njinga, Oluwasegun I. Eniayewu, Sa’ad T. Abdullahi, Amina J. Yusuf, Garba Dauda, Abdulhakim Abubakar, Zahatu Muhammad

1248 – 1255

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DOI: https://doi.org/10.26538/tjnpr/v9i3.48

Toxicological Evaluation of Co-Administration of Odogwu Bitters and Goko Cleanser Herbal Drinks on the Kidney of Adult Male Wistar Rats

Ifechukwu J. Obiesie, Darlington N. Onyejike, Ifeoma M. Onyejike, Sonia K. Okechukwu, Emeka A. Okubike

1256 – 1262

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DOI: https://doi.org/10.26538/tjnpr/v9i3.49

Dietary Virgin Coconut Exerted a Neuroprotective Effect via Upregulation of Nuclear Erythroid Factor and Downregulation Of Nuclear Factor KB Expression In Acrylamide-Induced Neurotoxicity: Role Of BDNF And AchE Pathways

Ayodeji J. Ajibare, Olabode O. Akintoye, Oluwatobiloba A. Oriowo, Abraham O. Asuku, Isaac A. Oriyomi , Joshua F. Adedara, Abosede M. Ayoola, Oyaname M. Adejumo

1263 – 1269

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DOI: https://doi.org/10.26538/tjnpr/v9i3.50

Anticonvulsant Studies of Methanol Extract of Hippocratea welwitschii

Kamal J. Muhammad, Michael O. Afolayan, Uzama Danlami, Abayomi T. Orishadipe, Paul C. Onyenekwe, Magaji G. Mohammed, Mariya T. Idris

1270 – 1273

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DOI: https://doi.org/10.26538/tjnpr/v9i3.51

Effect of Ethanol Extract of Amaranthus Viridis (Inine) on Potassium-Bromide-Induced Haematoxicity in Wistar Rats

Innocent I. Ujah, Godwin S. Alor, Cosmas E. Achikanu, Onuabuchi N. Ani, Chukwunonso A. Nsude, Uchenna B. Alozieuwa, Jane I. Ugochukwu, Ebere I. Akpata, Justice C. Ude, Kenechukwu C. Onyishi, Innocent O. Okpako, Chukwuemeka Okechukwu , Obiora E. Nneji, Chikezie K. Ogbu, Chinenye A. Anieke, Onyebuchi P. Ogbodo

1274 - 1279

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DOI: https://doi.org/10.26538/tjnpr/v9i3.52

Assessment of Extract from Glucose Oxidase-Cellulase Treated Jute Sticks and Green Amaranth Sticks for the Production of Lignocellulose-Based Bioethanol

Folake A. Fashola, Olubunmi I. Ibidapo, Adekunle S. Adaran, Abiodun H. Adebayo, Shalom N. Chinedu

1280 – 1297

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DOI: https://doi.org/10.26538/tjnpr/v9i3.53

In vitro and In silico Evaluation of the Oestrogenic Activities of Some Edible Vegetables in Nigeria

Finian K. Odoala, Babatunde A. Lawal, Ekaette S. Udoh, Abraham G. Idagu

1298 – 1308

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DOI: https://doi.org/10.26538/tjnpr/v9i3.54

In-silico investigation of the antischizophrenic activity of phytochemical constituents of Hymenocardia acida Tul. (Phyllantaceae)

Suleiman Danladi, Nafisah B. Lawal, Aisha M. Alhassan, Zainab I. Sani, Nazifi A. Abubakar, Abdulqadir O. Zubair, Salim Ilyasu, Umar I. Ibrahim

1309 – 1316

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DOI: https://doi.org/10.26538/tjnpr/v9i3.55

Phytochemicals and Antioxidant Properties of Ethanol Extract of Terap Fruit Seeds (Artocarpus odoratissimus)

Ika Yulianti, Doris Noviani, Titik Ismandari, Aditya Murtilaksono, Ririn Ariyanti

1317 – 1323

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DOI: https://doi.org/10.26538/tjnpr/v9i3.56

Cellular Response of Chitosan Loligo sp to Changes in Cell Metabolism of Enterococcus faecalis

Cut Soraya, Dharli Syafriza, Poppy Andriany, Subhaini Jakfar, Basri A. Gani

1324 – 1330

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DOI: https://doi.org/10.26538/tjnpr/v9i3.57

A Bibliometric Analysis of Research Trends in Bacterial Degradation of Plastics: Emerging Themes and Future Directions

Fahimatul Ulya, Aulanni’am, Akhmad Sabarudin, Evi Susanti, Eli H. Sanjaya, Heri Prayitno

1331 – 1339

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DOI: https://doi.org/10.26538/tjnpr/v9i3.58

Phenolic content and antioxidant activity of wild and cultivated Origanum compactum (Benth) leaf extract

Nadia Salhi, Asma Halmoune, Hamza El Finou, Abdelhamid Zaid, Lhoussaine El Rhaffari

1340 – 1345

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DOI: https://doi.org/10.26538/tjnpr/v9i3.59

Molecular docking analysis of 2,4,6-Octatrienoic acid with apoptotic protein targets: Insights into potential biological interactions

Shanmugam M Sivasankaran, Raju Kowsalya, Krishnan Baskaran, A. Therasa Alphonsa, Virumandi Sethupathi, Chakravarthy Elanchezhiyan

1346 – 1357

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DOI: https://doi.org/10.26538/tjnpr/v9i3.60

ERRATUM: Comprehensive Exploration of Ferulic Acid from Corn Leaves: Extraction, Structural Characterization, HPLC Quantification, and Anti-inflammatory Evaluation through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Studies

S Rajeshwari, Surendra K Chowdary, A Dileep, Suresh Joghee, Erica Alves, Bannimanth Gurupadayya, Nithin Mohan, Prashantha BR. Kumar, SubbaRao V. Madhunapantula

1358 – 1364

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DOI: https://doi.org/10.26538/

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