Tropical Journal of Natural Product Research (TJNPR)

Tropical Journal of Natural Product Research (TJNPR) is the official scientific publication of the Natural Product Research group, University of Benin; and it is available in both printed and electronic formats. The journal is published monthly.

Tropical Journal of Natural Product Research (TJNPR) is a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, papers discussing the screening of natural Product for biological activity against different health targets are also encouraged.

Vol. 8 No. 12 (2024): Tropical Journal of Natural Product Research (TJNPR)

Published: 2024-12-29

Plant-based probiotics – Viability, Stability and Products properties: Review

Nguyen T. Dung, Nguyen M. Chau, Tran T. Truc, Nguyen D. Vuong

9348 - 9353

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DOI: https://doi.org/10.26538/tjnpr/v8i12.1

Conventional Epilepsy Treatments in Morocco and Recommendations for Future Research Directions: An Up-to-Date Review

Abdelaziz Zennati, Youssef Khabbal

9354 - 9362

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DOI: https://doi.org/10.26538/tjnpr/v8i12.2

Emerging Role of Polyunsaturated Fatty Acids (PUFAs) on Human Brain Development and Neurological Diseases: A Systematic Review

Sana Noreen, Sanabil Anmol, Smeea Fatima, Rimsha Sattar, Zara Yameen, Saira Arshad, Ahasan Ullah Khan, Yunita Sari Pane

9363 - 9369

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DOI: https://doi.org/10.26538/tjnpr/v8i12.3

Phytochemistry and Antibacterial Efficacy of Kelakai (Stenochlaena palustris (Burm.f.) Bedd.) Extract: A Review

Muhammad R. F. Muslim, Lutfi Chabib, Hasyrul Hamzah

9370 - 9376

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DOI: https://doi.org/10.26538/tjnpr/v8i12.4

Effect of Garcinia mangostana Linn Extract on Systolic Blood Pressure and Inflammation in Hypertensives: A Systematic Review and Meta-Analysis

Arga S. Adji, Atiyatum Billah, Nadhifa N. Dhiyanisa, Nabella C. Nikmah, Kellyn T. Zenjaya, Wally W. Mukhammad, Bambang E. Suwito, Betty Roosihermiatie

9377 - 9385

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DOI: https://doi.org/10.26538/tjnpr/v8i12.5

Gas Chromatography-Mass Spectrometry Profiling, Antioxidant and Antibacterial Evaluations of Essential Oils Extracted from Mentha piperita and Mentha pulegium

Mohamed Amine El maimouni, Soukaina El amrani, Sanae Lairini, Rabia Bouslamti, Mohammed Er-rajy, Somdutt Mujwar, Mohammed Chalkha, Khalid Chebbac, Fouad El Akhal, Abdelhakim El Ouali Lalami

9386 - 9398

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DOI: https://doi.org/10.26538/tjnpr/v8i12.6

Demethylzeylasteral from Costus dubius (Afzel.)  K. Schum Leaves Inhibits Cyclooxygenase (COX-2) In vitro

Anabel B. Abulencia, Evangeline C. Amor

9399 – 9405

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DOI: https://doi.org/10.26538/tjnpr/v8i12.7

HPLC-MS/MS Profile, Analgesic and Anti-inflammatory Activities of Lawsonia inermis Seed Fractions

Amina Moutawalli, Fatima Zahra Benkhouili, Otman El-Guourrami, Najlae El-Otmani, Fadoua El-Ouazzani, Gokhan Zengin, Oguz Cakir, Mustafa Abdullah Yilmaz, Hanane Benzeid, Anass Doukkali, Ahmed Zahidi

9406 – 9413

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DOI: https://doi.org/10.26538/tjnpr/v8i12.8

Evaluation of the Stability of Argan Oil Nanoemulsions Formulated and Optimized through Experimental Design for Dermatological Applications

Yousra Mdarhri, Ikram Bouziane, Narjisse Mokhtari, Lama Rissouli, Ahmed Touhami, Fakhita Touhami, Mohamed Chabbi

9414 – 9421

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DOI: https://doi.org/10.26538/tjnpr/v8i12.9

Microscopic Characteristics, Chemical Composition and Antioxidant Activity of Stem and Leaf Extracts of Scurrula atropurpurea (Blume) Danser. Hemiparasite on Erythrophleum succirubrum Gagnep.

Pasakorn Bunchalee, Naruemon Phonchan, Teeraporn Katisart, Vachiraporn Pikulthong, Suthira Maneechai

9422 – 9429

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DOI: https://doi.org/10.26538/tjnpr/v8i12.10

Evaluation of Blood Coagulation Parameters in Chronic Kidney Diseases

Ahmad Q. Jaradat, Futoon A. Al-Rawashde, Marah Alsarayreh, Rama Q. Jaradat, Heba Y. Al-Radaideh, Khaled M. Khleifat

9430 – 9436

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DOI: https://doi.org/10.26538/tjnpr/v8i12.11

Comparison of Oven and Microwave Drying on Extraction of Spent Coffee Grounds Oil

Satriana, Lila Zahara, Yaumil Hafizah, Amrina Maulida, Yanna Syamsuddin, Muhammad D. Supardan

9437 – 9442

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DOI: https://doi.org/10.26538/tjnpr/v8i12.12

Potential of Combretum Indicum var. B flowers as Hepatoprotector Through Molecular Dynamic Methods

Samsul Hadi, Pratika Viogenta, Deni Setiawan, Kunti Nastiti, dan Khoirun Nisa

9443 – 9450

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DOI: https://doi.org/10.26538/tjnpr/v8i12.13

Blood Sugar Levels in terms of Differences in Intervention Time Duration for Corncob Ethanol Extract in Male Wistar Rats as a Model Of Diabetes Mellitus

Atik S. Wahyuningsih, Ahmad Yunus, Bambang Purwanto, Brian Wasita, Eti P. Pamungkasari, Ida Nurwati, Soetrisno Soetrisno

9451 – 9455

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DOI: https://doi.org/10.26538/tjnpr/v8i12.14

Antioxidant, Anti-Melanogenesis, and Cytotoxic Effects of Clitoria ternatea (Butterfly Pea) Flower Extract on B16 Melanoma Cells

Fenita Shoviantari, Tristiana Erawati, Widji Soeratri, Mahardian Rahmadi, Galang W. Permadi, Muhammad Rafibahtiyar

9456 – 9460

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DOI: https://doi.org/10.26538/tjnpr/v8i12.15

Effect of Umbelliferone on pharmacokinetic and pharmacodynamic parameters of Glibenclamide in Streptozocin induced diabetic rats

Puttireddy S. Malathy , Yellu N. Reddy

9461 – 9466

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DOI: https://doi.org/10.26538/tjnpr/v8i12.16

Cytotoxic and Antioxidant Activities of Flavonols from Melicope quercifolia

Ratih D. Saputri, Norizan Ahmat, Tjitjik S. Tjahjandarie, Mulyadi Tanjung

9467 – 9469

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DOI: https://doi.org/10.26538/tjnpr/v8i12.17

Optimization of Flavonoid Extraction and Antioxidant Capacity from Acanthus ilicifolius Using Microwave-Assisted Extraction and I-Optimal Response Surface Methodology

Waras Nurcholis, Indah Z. Septiawati, Laila Najmi, Felizhca A. Sutandy, Lava Febrian, Ghina C. Fitriasari, Ahmad F. Ramdhani, Annisa Zahra, Syarifah I. Aisyah, Laksmi Ambarsari, Irni F. Hindaningrum, Made Artika

9470 – 9475

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DOI: https://doi.org/10.26538/tjnpr/v8i12.18

Differentially Expressed Genes (DEGs) Analysis and In Silico Studies Identify Tumor Necrosis Factor (TNF) Inhibition and Peroxisome Proliferator-Activated Receptor Alpha (PPARA) Activation as Targets for Gallic Acid Derivatives in Insulin Resistance

Dwi Anita Suryandari, Aryo Tedjo, Fadilah Fadilah

9485 - 9479

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DOI: https://doi.org/10.26538/tjnpr/v8i12.19

Theaflavin Alleviates Memory Deficit and Anxiety-Like Phenotypes in Valproic Acid Murine Model of Autism: Impact on Cholinergic and Oxido-Nitrigic Stress Mechanisms

Celestine O. Akpovwre, Anthony T. Eduviere, Happy Isibor , Kesiena E. Edje, Lawrence O. Ewhre, Akinyele O. Akinsola, Joy E. Idada, Festus E. Avwotuhwaye

9486 – 9493

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DOI: https://doi.org/10.26538/tjnpr/v8i12.20

Formulation and Physicochemical Evaluation of Anti-Ageing Polyherbal Powdered Facial Mask

Eva Jourdain, Mogana Rajagopal, Puay-Luan Tan, Kushagra Khanna, Rubhan Chandran

9494 – 9500

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DOI: https://doi.org/10.26538/tjnpr/v8i12.21

Evaluation of Antirheumatoid Arthritis Activity of Aqueous Methanol Extract of Globba winitti Rhizome

Ramya Madhiri, Rakesh Barik

9501 – 9508

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DOI: https://doi.org/10.26538/tjnpr/v8i12.22

Insulin Secretion and Glucose Uptake Enhancement by Mimosa pudica and Abutilon indicum: Potential Antidiabetic Therapy

Benchawan Sopha, Supachoke Mangmool, Nutputsorn Chatsumpun, Nakkawee Saengklub, Worawan Kitphati, Penchom Peungvicha

9509 – 9516

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DOI: https://doi.org/10.26538/tjnpr/v8i12.23

Phytochemical analysis, in vitro screening of antioxidant and antibacterial potential of Cajuput (Melaleuca cajuputi) extract against pathogenic Vibrio spp.

Sunanta Khongsai, Chakhriya Chalad, Preeda Phumee

9517 – 9523

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DOI: https://doi.org/10.26538/tjnpr/v8i12.24

Insulin Resistance and Propolis in Polycystic Ovary Syndrome (PCOS) Model Rats

Alfaina Wahyuni, Nur S. Meida, Alexan J. Ramadhan

9524 – 9528

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DOI: https://doi.org/10.26538/tjnpr/v8i12.25

Optimization of Andrografolid Extraction from the Herb Sambiloto (Andrographis Paniculata (Burm.F.) Nees) Using a Combined Maceration and Refluction Method

Sani N. Fitriansyah, Komar Ruslan, Defi N. Rizky, Dewi Munthary, Hesti Riasari

9529 – 9536

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DOI: https://doi.org/10.26538/tjnpr/v8i12.26

In Vivo and In Silico Evaluation of Petroselinum crispum Leaf Fractions as Anti-Alopecia

Silviana Hasanuddin, Agustina, Dolih Gozali, Muhammad Arba, Resmi Mustarichie, Muhammad Isrul

9537 – 9546

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DOI: https://doi.org/10.26538/tjnpr/v8i12.27

Ethnobotanical Investigation of Aromatic and Medicinal Plants Used in Traditional Treatments in Ain Mediouna and Thar Souk (Taounate; Morocco)

Abdelouahid Laftouhi, Youssef El-assri, El-mehdi El-assri, Amal Elrherabi, Mohamed A. Mahraz, Noureddine Eloutassi, Zakia Rais, Abdslam Taleb, Mustapha Taleb

9547 – 9554

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DOI: https://doi.org/10.26538/tjnpr/v8i12.28

Bioactive Extracts from Padina boryana Thivy from Phu Quoc Island, Vietnam: In vitro Antioxidant, Anticancer, Alpha-glucosidase inhibitory, Anti-inflammatory, Antimicrobial, and Hepatoprotective Activities

Nguyen D. Tuan, Nguyen C. Quoc, Duong N. Ly, Banh T. Tuyen, Le D. Quang, Huynh H. Phien, Tran Q. De, Tran T. Men

9555 – 9559

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DOI: https://doi.org/10.26538/tjnpr/v8i12.29

In vivo Effect of Momordica charantia on Dipeptidyl Peptidase-4 Activity in Diabetic Rats

Muhammad Fadhol Romdhoni, Muchsin Doewes, Soetrisno Soetrisno, Ratih Puspita Febrinasari

9560 – 9563

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DOI: https://doi.org/10.26538/tjnpr/v8i12.30

Anti-oxidative Potential of Essential Oil of Rosmarinus officinalis in Cadmium-induced Neurotoxicity on the Cerebellum of Adult Wistar Rats

Chibuike V. Chukwu, Chimdike G. Omejua, Chinemerem O. Onyirimba, Ikenna K. Uchendu

9564 – 9570

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DOI: https://doi.org/10.26538/tjnpr/v8i12.31

Method Development and Selection of Verbascoside-Rich Acanthus Species and their Isolation Using Centrifugal Partition Chromatography

Piyanut Tongpasuk, Tossaton Charoonratana

9571 – 9577

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DOI: https://doi.org/10.26538/tjnpr/v8i12.32

Optimization of Nanostructured Lipid Carriers for Essential Oil of Artemisia herba-alba

Umi Nafisah, Erindyah R. Wikantyasning, Anita Sukmawati 

9578 – 9585

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DOI: https://doi.org/10.26538/tjnpr/v8i12.33

Acute Oral Toxicity Assessment of Morinda citrifolia L. (Noni) Leaves in Experimental Mice

Jon Farizal, Zamharira Muslim, Rahmad Abdillah

9586 - 9590

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DOI: https://doi.org/10.26538/tjnpr/v8i12.34

Green Synthesis, Optimization and Characterization of Carrot Extract Silver Nanoparticles

Nadia Pramasari, Ade G. Anjani, Faisal A. Muslikh, Tri P. Lestari, Fenita Shoviantari, Shinta D. Septyaningrum, Intan S. Melati, Gilang Y. Randy

9591 – 9595

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DOI: https://doi.org/10.26538/tjnpr/v8i12.35

Influence of Geographical Origin on Essential Oil Contents in Curcuma aeruginosa Roxb. Rhizomes in Central Java, Indonesia

Bekti Nugraheni, Abdul Rohman, Ratna A. Susidarti, Purwanto Purwanto

9596 – 9602

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DOI: https://doi.org/10.26538/tjnpr/v8i12.36

Gum Arabic-Based Microencapsulation of Delonix regia Extract and Its In Vitro Antibacterial Activity

Yeyen S. Senge, Izaz A. Zahara, Irfan Mustafa, Anna Safitri

9603 – 9609

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DOI: https://doi.org/10.26538/tjnpr/v8i12.37

Optimization of Nanostructured Lipid Carriers (NLC) Extract Crude Fucoidan Algae Brown (Sargassum chrysanthemum): Design and Characterization

Lilies W. Ariani, Abdul K. Zulkarnain, Triana Hertiani, Arief Nurrochmad

9610 – 9618

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DOI: https://doi.org/10.26538/tjnpr/v8i12.38

Evaluation of the Phytochemical Constituents, Toxicity Profile, and Pharmacological Activities of Qust al-Hindi Herb (Saussurea costus (Falc.))

Zilhadia, Vivi Anggia, Ismiarni Komala, Isra Janatiningrum, Nurmeilis, Azrifitria, Muhammad Taher, Febi D. Aprilia

9619 – 9626

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DOI: https://doi.org/10.26538/tjnpr/v8i12.39

Formulation of Ketoconazole Niosomal Delivery System using Non-Ionic Surfactants

Septiana T. Pamungkas, Fith K. Nursal, Fitria Nugrahaeni, Kori Yati

9626 - 9631

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DOI: https://doi.org/10.26538/tjnpr/v8i12.40

Anti-Atherosclerotic Effect of Nigella sativa L. in High-Fat diet Fed Wistar Rats

Abdurrohman Izzuddin, Muhammad Ridwan, Cut D. Iskandar, Adi Purnawarman, Fauzul Husna, Nurkhalis Nurkhalis, Dhanang A. Yafi, Fauzan Fajri, Fitriani Fitriani

9632 – 9636

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DOI: https://doi.org/10.26538/tjnpr/v8i12.41

Comparison of Extraction Methods and Characterization of Cellulose from Sugarcane Bagasse (Saccharum officinarum L.) for Bioplastic Food Packaging

Aisyah Rusdin, Ahyar Ahmad, Abdul Karim, Syahruddin Kasim, Abdul W. Wahab, Dahlang Tahir, Eli Rohaeti, Paulina Taba, Awaluddin, Maswati Baharuddin, Sulistiani Jarre, Sulastri, Harningsih Karim

9637 – 9642

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DOI: https://doi.org/10.26538/tjnpr/v8i12.42