Anti-Mycobacterial Activity of Polycarpine and Polycarpaurine A from an Indonesia Marine Ascidian Polycarpa sp. http://www.doi.org/10.26538/tjnpr/v7i9.31
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Abstract
Marine ascidians are an abundant source of new bioactive metabolites. The current investigation aimed at characterizing anti-mycobacterial compounds from Indonesian marine ascidian Polycarpa sp. After extracting ethanol, Ascidian Polycarpa sp. was segregated with EtOAc and H2O. Ethyl acetate extract was purified using preparative HPLC. Identification and characterization of compounds using spectroscopic analysis. Anti-mycobacterial activity testing
using the disc diffusion method on Mycobacterium smegmatis. This study showed that the ethyl acetate extract of ascidian Polycarpa sp produced two known compounds polycarpine (1) and palycarpaurine A (2). Compounds 1 and 2 exhibited activity against Mycobacterium smegmatis at 50 g/disc, with 12- and 10-mm inhibition zones, respectively. This study suggests that polycarpine (1) and palycarpaurine A (2) have potential compounds for antimycobacterium.
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