Estimation of Oxidative Stress Enzymes and Vitamins Levels in Acute Lymphocytic Leukemia Patients in the Governorate of Basrah, Iraq
doi.org/10.26538/tjnpr/v6i4.13
Keywords:
Acute lymphocytic leukemia, Catalase, Glutathione peroxidase, Superoxide dismutase, Vitamin A, Vitamin EAbstract
Acute lymphocytic leukemia (ALL) is a multi-disease that affects most people, especially children. The present research was conducted to estimate some oxidative stress enzyme and antioxidant vitamin levels in the blood serum of Iraqi ALL patients in relation to sex and age. In this study, 100 patients (57 men and 43 women) with ALL disease and 80 healthy subjects (43 men and 37 women) ranging in age from 1 to 17 years were enrolled. Venous blood was clinically collected from both the ALL patients and healthy individuals. Blood serum levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) were tested using the enzyme-linked immunosorbent assay. Vitamins A, E, and C were also assessed. The amount of catalase (CAT) in the sample was measured using a spectrophotometric technique. The results revealed that the levels of GPx, SOD, and CAT decreased significantly (P<0.0001) in ALL patients compared to the control group. Also, the levels of vitamins A, E, and C decreased significantly (P<0.0001) in ALL patients compared to the control group. The findings of this study revealed that GPx, SOD, and CAT enzymes, as well as vitamins A, E, and C are considered key biochemical markers of ALL disease.
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