Effect of Methanol Extract of Curcuma longa L on some Biochemical and Haematological Parameters in Albino Rats doi.org/10.26538/tjnpr/v4i11.30

Abstract

C. longa (Turmeric) is a plant that is used both as spice and medicine. Despite all the documented importance of turmeric in both nutrition and medicine, there is little or no scientific evidence on the biochemical effect of the methanol extract in albino rats. This study was aimed at evaluating the effect of the methanol extract on some selected biochemical parameters in albino rats. In
the assessment of the 15-day sub-acute toxicity profile of the methanol extract of C. longa, acuteand sub-acute toxicity study was performed following standard laboratory procedures using twenty albino rats which were divided into four groups of 5 rats each. The rats were administered different concentrations of the methanol extracts, 100 mg/kg b.wt, 200 mg/kg b.wt and 500mg/kg b.wt whereas control received distilled water only. At the end of each period of administration, some biochemical parameters and haematological parameters were analysed. There was a significant increase (p<0.05) in parameters such as High-Density Lipoprotein cholesterol (HDL-c), malondialdehyde, haemoglobin, Glutathione reductase (GHSR), red blood cell count, and packed cell volume in rats administered the methanol extract. In contrast, a significant decrease (p < 0.05) was also observed in parameters such as Catalase (CAT), Superoxide dismutase (SOD), and blood glucose level. The result has shown that the methanol extract of turmeric has blood glucose and blood lipid-lowering potentials, and as well possesses hematopoietic potentials.