Anti-Inflammatory Activity of KNC, a Vietnamese Herbal Medicine Prescription on RAW 264.7 Cells

doi.org/10.26538/tjnpr/v4i11.14

Authors

  • Xuan C. Dau Vietnam University of Traditional Medicine, 2 Tran Phu street, Ha Dong district,Hanoi 12110,Vietnam
  • Thi N. Nguyen Vietnam University of Traditional Medicine, 2 Tran Phu street, Ha Dong district,Hanoi 12110, Vietnam
  • Manh H. Tran Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hoa Cuong Nam ward, Hai Chau district, Da Nang city 550000, Vietnam
  • Hoang N. Nguyen Vietnam Military Medical University, 160 Phung Hung street, Ha Dong district,Hanoi 12108,Vietnam

Keywords:

Inflammation, 7 cells, RAW 264, KNC, Vietnamese traditional medicine

Abstract

Kinh-Nghiem-Canh (KNC) is a herbal priscription drug used for the treatment of musculoskeletal pain in the Vietnamese oriental medicine. The anti-inflammatory effect of KNC decoction in lipopolysaccharide (LPS)-treated RAW 264.7 cells was evaluated using LISA test kits for detection of inflammatory mediators PGE2 and proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. Results showed that anti-inflammatory properties of KNC resulted from the inhibition of nitric oxide (NO) production, prostaglandin E2 (PGE2) release, and other proinflammatory cytokines such as IL-1????, TNF-????, and IL6 in a RAW 264.7 macrophage cell line.

References

Archer CB, Page CP, Paul W, Morley J, MacDonald DM. Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin. Br J Dermatol. 1984; 110(1):45-50.

Xu Y, Liu Q, Guo X, Xiang L, Zhao G. Resveratrol attenuates IL-33-induced mast cell inflammation associated with inhibition of NF-κB activation and the P38 signaling pathway. Mol Med Rep. 2020; 21(3):1658-1666.

Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987; 327(6122):524-526.

Rocca B and FitzGerald GA. Cyclooxygenases and prostaglandins: shaping up the immune response. Int Immunopharmacol. 2002; 2:603-630.

Fu X, Tan T, Liu P. Regulation of autophagy by nonsteroidal anti-inflammatory drugs in cancer. Cancer Manag Res. 2020: 16(12):4595-4604.

Upawi SN, Ahmad MF, Abu MA, Ahmad S. Management of bleeding irregularities among etonogestrel implant users: Is combined oral

contraceptives pills or nonsteroidal antiinflammatory drugs the better option? J. Obstet Gynaecol Res. 2020; 46(3):479-484.

AlKhalil M, Al-Hiari Y, Kasabri V, Arabiyat S, AlZweiri M, Mamdooh N, Telfah A. Selected pharmacotherapy agents as antiproliferative and antiinflammatory compounds. Drug Dev Res. 2020; 81(4):470-490.

Gao C, Liu L, Zhou Y, Bian Z, Wang S, Wang Y. Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease. Chin Med. 2019; 17(14):23.

Do HB, Dang QC, Bui XC. Plants and Animals using as Medicinal materials in Vietnam. Science and Technology Publishing, Ha Noi, 2006. 568-925 p.

Do TL. Medicinal Plants in Vietnam, Health Publishing, Ha Noi, 2015. 507- 509 p, 721-723 p.

Nguyen NK. Basic Theology in Vietnamese Oriental Medicines, Vietnam Education Publishing, Ha Noi, 2011. 161-265 p.

Vietnam Ministry of Health. Vietnamese Pharmacopoeia, episode 2, 5th Edition, Health Publishing, Ha Noi, 2018. 1154-1379 p.

Snyde SH and Bredt DS. Biological roles of nitric oxide. Sci Am. 1992; 266(5):68-71, 74-77.

Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Sci. 2001; 294(5548):1037- 1043.

Pernow J, Mahdi A, Yang J, Zhou Z. Red blood cell dysfunction: a new player in cardiovascular disease. Cardiovasc Res. 2019; 115(11):1596-1605.

Liu G, Xie J, Shi Y, Chen R, Li L, Wang M, Zheng M, Xu J. Sec-O-glucosylhamaudol suppressed inflammatory reaction induced by LPS in RAW264.7 cells through inhibition of NF-κB and MAPKs signaling. Biosci Rep. 2020; 40(2):BSR20194230.

Chun JM, Kim HS, Lee AY, Kim SH, Kim HK. Antiinflammatory and antiosteoarthritis effects of Saposhnikovia divaricata ethanol extract: in vitro and in vivo studies. Evid-Based Compl Altern Med. 2016; 1984238.

Vo VA, Lee JW, Chang JE, Kim JY, Kim NH, Lee HJ, Kim SS, Chun W, Kwon YS. Avicularin inhibits lipopolysaccharide-induced inflammatory response by suppressing ERK phosphorylation in RAW 264.7 macrophages. Biomol Ther. 2012; 20(6):532-537.

Taguchi K, Hagiwara Y, Kajiyama K, Suzuki Y. Pharmacological studies of Houttuyniae herba; the anti-inflammatory effect of quercitrin. Yakuguku Zusshi. 1993; 113(4):327-333.

Gutiérrez-Venegas G, Ventura-Arroyo JA, ArreguínCano JA, Ostoa-Pérez MF. Flavonoids inhibit iNOS production via mitogen activated proteins in lipoteichoic acid stimulated cardiomyoblasts. Int Immunopharmacol. 2014; 21(2):320-327.

Shin EM, Zhou HY, Guo LY, Kim JA, Lee SH, Merfort I, Kang SS, Kim HS, Kim S, Kim YS. Antiinflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages. Int Immunopharm. 2008; 8(11):1524- 1532.

Tang YF, An N, Li YH. Two new isoflavonoid glucosides from the roots of Achyranthes bidentata and their activities against nitric oxide production. Phytochem Lett. 2016; 17:187-189.

Hu XD, Yang Y, Zhong XG, Zhang XH, Zhang YN, Zheng ZP, Zhou Y, Tang W, Yang YF, Hu LH, Zuo JP. Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages. J Ethnopharmacol. 2008; 120:447-451.

Claria J. Cyclooxygenase-2 biology. Curr Pharma Des. 2003; 9:2177-2190.

Bondeson J. The mechanisms of action of diseasemodifying antirheumatic drugs: a review withemphasis on macrophage signal transduction and the induction of proinflammatory cytokines. Gen Pharmacol. 1997; 29:127-150.

Shohami E, Ginis I, Hallenbeck JM. Dual role of tumor necrosis factor alpha in brain injury. Cytokines Growth Factor Rev. 1999; 10:119-130.

Yang T, Zhang A, Pasumarthy A, Zhang L, Warnock Z, Schnermann JB. Nitric oxide stimulates COX-2 expression in cultured collecting duct cells through MAP kinases and superoxide but not cGMP. Am J Physiol Renal Physiol. 2006; 291(4):F891-F895.

Hibi M, Nakajima K, Hirano T. IL-6 cytokines family and signal transduction: a model of the cytokines system. J Mol Med. 1996; 74:1-12.

Van Snick J. Interleukin-6: an overview. Annu Rev Immunol.1990; 8:253-278.

Peluso I, Raguzzini A, Serafini M. Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: a systematic review and meta-analysis. Mol Nutr Food Res. 2013; 57(5):784-801.

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Published

2020-11-01

How to Cite

Dau, X. C., Nguyen, T. N., Tran, M. H., & Nguyen, H. N. (2020). Anti-Inflammatory Activity of KNC, a Vietnamese Herbal Medicine Prescription on RAW 264.7 Cells: doi.org/10.26538/tjnpr/v4i11.14. Tropical Journal of Natural Product Research (TJNPR), 4(11), 922–925. Retrieved from https://tjnpr.org/index.php/home/article/view/958

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