Anti-Inflammatory Activity of KNC, a Vietnamese Herbal Medicine Prescription on RAW 264.7 Cells


  • Xuan C. Dau Vietnam University of Traditional Medicine, 2 Tran Phu street, Ha Dong district,Hanoi 12110,Vietnam
  • Thi N. Nguyen Vietnam University of Traditional Medicine, 2 Tran Phu street, Ha Dong district,Hanoi 12110, Vietnam
  • Manh H. Tran Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hoa Cuong Nam ward, Hai Chau district, Da Nang city 550000, Vietnam
  • Hoang N. Nguyen Vietnam Military Medical University, 160 Phung Hung street, Ha Dong district,Hanoi 12108,Vietnam


Inflammation, 7 cells, RAW 264, KNC, Vietnamese traditional medicine


Kinh-Nghiem-Canh (KNC) is a herbal priscription drug used for the treatment of musculoskeletal pain in the Vietnamese oriental medicine. The anti-inflammatory effect of KNC decoction in lipopolysaccharide (LPS)-treated RAW 264.7 cells was evaluated using LISA test kits for detection of inflammatory mediators PGE2 and proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. Results showed that anti-inflammatory properties of KNC resulted from the inhibition of nitric oxide (NO) production, prostaglandin E2 (PGE2) release, and other proinflammatory cytokines such as IL-1????, TNF-????, and IL6 in a RAW 264.7 macrophage cell line.


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How to Cite

Dau, X. C., Nguyen, T. N., Tran, M. H., & Nguyen, H. N. (2020). Anti-Inflammatory Activity of KNC, a Vietnamese Herbal Medicine Prescription on RAW 264.7 Cells: Tropical Journal of Natural Product Research (TJNPR), 4(11), 922–925. Retrieved from

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