Attenuation of Oxidative Enzymes Induction in Palm Oil Fractions Pre-treated Cadmium Intoxicated Rats
doi.org/10.26538/tjnpr/v3i4.2
Keywords:
Attenuate,, Induce,, Cadmium,, Palm oil and Oxidative EnzymesAbstract
Impairing the toxic effects of cadmium (Cd) by diet induced antioxidant defence systems is an innovative approach to managing cadmium poisoning. The present study investigated the ability of crude palm oil (Elaeis guinensis) and its fractions to prevent the induction of aldehyde and sulphite oxidative enzymes in acute cadmium intoxicated male rats. The study comprised of six groups, which had group A as control, B as cadium group and C-F as test groups. Group A received No Cadmium and no Palm oil fraction, Group B received 20mgCd/Kg body weight Groups C-F received 5ml/Kg body weight of appropriate palm oil fraction namely crude palm oil (CPO), Silica Gel Extract (SGE), Bleached Palm oil and unsaponifiable extract for 28 days prior to a single dose of cadmium in form of cadmium chloride on day 29 (20mgCd/Kg body weight). Rats were sacrificed 12h, 24h and 48h post-cadmium administration and the activities of aldehyde oxidase (AO) and sulphite oxidase (SO) were determined. Results obtained indicate a significant rise in AO and SO activities in the liver, kidney, heart, muscle tissues and serum between 12-48 hours following Cd administration compared to control. Administration of palm oil extracts caused significant reduction (p<0.05) in AO and SO activities. Results indicate tha acute Cd administration induces the expression of oxidative enzyme within 12 hours but pre-treatment of rats with palm oil and its fractions reduces their expression.
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