Evaluation of the Therapeutic Effect of Curcumin Phytosomes on Streptozotocin-Induced Diabetic Rats doi.org/10.26538/tjnpr/v6i4.11
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Abstract
Diabetes Mellitus (DM) has been described as a metabolic disorder that results in chronic high blood sugar level. However, it is difficult to evaluate the effectiveness of natural products such as curcumin on diabetes and its complications, due to the low intestinal bioavailability and the low systemic absorption rate. The study evaluated the efficacy of the phytosome in its ability to enhance the absorption of curcumin and thus its effect on blood sugar level and lipid profile in streptozotocin (STZ)-nicotinamide-induced diabetic rats. Curcumin and combination of curcumin and phytosomes (Cur-P) were administered orally at 150 and 250 mg/kg, respectively, to streptozotocin (STZ)-nicotinamide induced DM rats. Metformin was used as a positive control. The blood glucose level and lipid profile were monitored for 21 days. The results showed a clear decline in the levels of blood glucose, cholesterol, triglycerides, and the low-density lipoprotein (LDL), cholesterol, in addition to a significant rise in the high-density lipoprotein (HDL). The hypoglycemic and hypolipidemic effects caused by treatment with Cur-P were higher than those treated with Curcumin alone at the same dose, i ndicating that the phytosomes enhances the potential of absorption and bioavailability of Curcumin. The findings suggest that Cur-P may have a potential therapeutic effect on diabetes through enhancing the potential of absorption and bioavailability of curcumin.
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