Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats doi.org/10.26538/tjnpr/v3i3.2
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Abstract
Ulcers are lesions in the mucosa of gastrointestinal tract, characterized by different stages of necrosis. Ulcer management has been challenging because of increasing antimicrobial resistance and indiscriminate use of complex antithrombotic therapy. Anti-ulcer activities of the fractions of the crude methanol extract of Khaya senegalensis was evaluated against ethanol-induced
gastric ulcer. The powdered bark of K. senegalensis was extracted using absolute methanol and the crude extract was serially partitioned with n-hexane and ethyl acetate. The aqueous methanol (AMF), hexane (HEF) and ethyl acetate (EAF) fractions of K. senegalensis were tested for acute toxicity and further evaluated for gastric anti-secretory, gastroprotective and antioxidant effects
in rat. The EAF and AMF significantly (P < 0.05) decreased the concentration of gastric HCl at 400 and 800 mg/kg. All the fractions significantly lowered (P < 0.05) gastric ulcer indices when compared with the normal saline control group (NS). Furthermore, the fractions significantly (P < 0.05) increased the concentration of gastric mucus compared to NS. The AMF and EAF fractions significantly (P < 0.05) reduced the concentration of malondialdehyde in the gastric tissue relative to NSgroup. The three fractions (AMF, EAF and HEF) significantly (P < 0.05) increased the level of superoxide dismutase activity when compared with NS. However, the activity of catalase was significantly (P < 0.05) decreased in the groups treated with AMF and EAF when compared with the NS. Findings in this study strongly suggest that Khaya senegalensis has anti-ulcerative properties, which could be due to its antisecretory and antioxidant
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