Effect of Bisphenol A and Di-(2-ethylhexyl) phthalate on Haematological and Renal Function Parameters
doi.org/10.26538/tjnpr/v2i12.2
Keywords:
Bisphenol A,, Di(2-ethylhexyl) phthalate,, Renal,, haematological,, plastic polymers.Abstract
The ubiquitous nature of plastics has caused increased concerns about the effects of exposure of humans to plastic polymers particularly the endocrine-disrupting chemicals (EDCs) like Di-(2-ethylhexyl) phthalate (DEHP) and Bisphenol A (BPA) used in plastic production. The aim of this study was to investigate the effects of BPA and DEHP on haematological and renal function parameters. A total of 60 adult Wistar rats were divided into four groups (I-IV) of 15 animals each. Group I was fed with rodent feed only (control), while groups II - IV were administered 5mg/kg/day of BPA, 0.5 mg/kg/day of DEHP and a mixture of 0.5 mg/kg/day of BPA and 0.5
mg/kg/day of DEHP, respectively. The animals were monitored for 42 days. The result shows that there were significant (p < 0.05) increase in pack cell volume, haemoglobin, red blood cell, reticulocyte, total white blood cell, lymphocyte, platelet, sodium ion and creatinine concentrations in group II, while the concentrations of urea, potassium and bicarbonate were reduced. In group III, there were increase in the concentrations of pack cell volume, mean cell haemoglobin, and mean cell volume, lymphocyte, platelets, sodium ion, and urea while creatinine concentration was reduced. In group IV, there were increase in the concentration of mean cell haemoglobin concentration, reticulocyte, total white cell count, neutrophil, lymphocyte, platelet, sodium ion and a decrease in creatinine and potassium ion concentration. The present study has shown a possible haematinic effect of BPA and DEHP. They also cause significant alterations in kidney function test parameters.
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