Antibacterial Activity of a Triterpenoid from n-Butanol Extract of the Root Bark of Ficus sycomorus (Linn)
doi.org/10.26538/tjnpr/v2i10.3
Keywords:
Ficus sycomorus,, lupeol,, Microwave-Assisted Extraction,, root barkAbstract
Microorganisms have developed and are still developing resistance to most antibacterial agents in use. Thus, there is a need to search for new drugs that are of organic origin from medicinal plants, because they serve as a primary source of new medicine and lead compounds for the development of new antibacterial agents. The aim of this study was to isolate, characterise and investigate the antibacterial activity of lupeol from the root bark of Ficus sycomorus. Phytochemical investigation of n-butanol extract from the root bark of Ficus sycomorus showed the occurrence of steroids, triterpenes, flavonoids, alkaloids, and tannins following microwave-assisted extraction. A triterpenoid compound, lupeol, was isolated from the root bark of the plant. The isolated compound was screened for antibacterial activity against Escherichia coli, Samonella typhi, Bacillus subtilis and Staphylococcus aureus using agar well diffusion method. The isolated compound exhibited antibacterial activity against some of the tested microorganisms; B. subtilis and E. coli. This showed that the compound may serve as a potential source of antibacterial agent
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