Synthesis, Characterization and Antimicrobial Evaluation of Co(II), Ni(II) and Cu(II)  Schiff base complexes of (Z)-4-(1-pyridin-4-ylimino) propyl)phenol: doi.org/10.26538/tjnpr/v2i9.4

Samuel A. Agbese; Gideon  A. Shallangwa; Sulaiman O. Idris

Authors

Samuel A. Agbese Department of Chemistry, Ahmadu Bello University Zaria, Nigeria
Gideon A. Shallangwa Department of Chemistry, Ahmadu Bello University Zaria, Nigeria
Sulaiman O. Idris Department of Chemistry, Ahmadu Bello University Zaria, Nigeria

Keywords:

Schiff base,, FTIR,, UV-Visible, metal complexes,, antimicrobial.

Abstract

The demand for discovery and development of new antimicrobial agents has continued to increase due to the emergence and increasing prevalence of drug resistant pathogens. The study evaluated the synthesis, characterization and antimicrobial activity of Co(II), Ni(II) and Cu(II) Schiff base complexes derived from condensation of (Z)-4-(1-pyridin-4-ylimino) propyl) phenol with their
respective metal chlorides. The synthesized Co(II), Ni(II) and Cu(II) Schiff base complexes were characterized by UV-Visible analysis, FTIR, Molar conductivity measurement and Magnetic susceptibility test. The results of the FTIR suggest that the metal complexes possess coordinated water molecules and the absorption band with wavenumber 1651.12 and 1658.84 cm-1 shows that the nitrogen of the imine bond participated in the coordination to the metal center. The magnetic susceptibility measurements show magnetic moments of 4.68 BM, 3.10 BM and 1.95 BM corresponding to Co (II), Ni (II) and Cu (II) complexes, respectively, thus, indicating the metal complexes possess octahedral geometry. The molar conductivity tests show values of 82.90 Ω1mol-1
cm2, 62.60 Ω-1mol-1cm2 and 50.80 Ω-1mol-1cm2 which corresponds to Co(II), Ni(II) and Cu(II) complexes respectively. The molar conductivity values for the complexes show that they do not readily dissociate in solution and are non-electrolytic in nature. The metal to ligand ratio for each of the metal complexes is 1:2. The metal complexes were evaluated for their antimicrobial activity against two Gram positive bacteria, two Gram negative bacteria and two fungi organisms. The synthesized metal complexes show significant activities against most of the test organisms.

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