Effect of Selected Pure Compounds of Plant Origin on the Proliferation, Adhesion, Migration, and Invasion of Human Prostate Cancer Cells doi.org/10.26538/tjnpr/v5i2.7
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Abstract
Signalling cascade of autocrine/paracrine growth factors plays an important role in promoting prostate cancer (PCa) cells growth, survival, migration, invasion, and progression. PCa is one of the most important causes of death in men, thus new therapeutic approaches are needed. The objective of this study is to investigate whether α-terpinene, -caryophyllene, linalool, luteolin, and quercetin exert antiproliferative, anti-adhesion, anti-migratory, and anti-invasion activity in PCa cell line models. The results showed that all five compounds exhibited growth inhibitory activities on both PCa cell lines (PC3 and DU145). Luteolin was the most potent antiproliferative compound against PC3 and DU145 cells with IC50 values of 70.19 µM and 37.46 µM, respectively. A number of techniques, including cell adhesion, wound healing, Transwell migration and invasion assays were used to investigate the ability of these compounds to inhibit migration/invasion of PCa cells at non-toxic concentrations. Our findings highlight the potential of luteolin and quercetin to inhibit the invasion and migration of PC3 and DU145 cells without causing cytotoxicity. However, further studies are still needed to reveal their molecular mechanisms of action
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