Antidepressant Activity of Methanol whole Plant Extract of Tapinanthus dodoneifolius (DC) Danser in Swiss Mice doi.org/10.26538/tjnpr/v5i3.28
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Abstract
Depression remains one of the major contributors to global burden of disease despite multiple approaches to its treatment. Plants derived medicines serve a great role in confronting the challenges related to the treatment of various ailments. The study evaluated an antidepressant potential of the whole plant methanol extract of Tapinanthus dodoneifolius. Preliminary phytochemical screening was carried out using a standard method. Oral median lethal dose (LD50) was determined using the guideline by Organization for Economic Co-operation and Development (OECD). The antidepressant effect of the extract was assessed using the Tail Suspension Test (TST) and Forced Swim test (FST) in mice. Also, effect of the plant extract on ambulation was studied using Open Field Test (OFT). Immobility duration within four (4) minutes in TST and FST as well as locomotory activity in open field was determined for each animal. Preliminary Phytochemical screening of the methanol extract of T. dodoneifolius indicated positive for saponins, cardiac glycosides, tannins, steroids, triterpenoids and flavonoids. Median lethal dose (LD50) of the extract was found to be above 5000 mg/kg. The extract significantly (p < 0.05) shorten the immobility time in the TST at the tested dose of 375 mg/kg while only the highest dose of the extract (1500 mg/kg) significantly (p < 0.05) reduced immobility time in the FST. The extract did not significantly affect ambulation in the OFT. The study revealed that the methanol extract of the whole plant of Tapinanthus dodoneifolius produces an antidepressant activity.
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