Effect of Lactobacillus acidophilus and Lactobacillus plantarum on Weight Reduction in Obese Rats doi.org/10.26538/tjnpr/v5i4.27
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Abstract
Obesity is a risk factor for diseases such as high blood pressure and type 2 diabetes. Over the years, alternatives to the use of drugs and surgery being used to treat obesity are being sought to improve health. This research aimed to determine the effect of two Lactobacillus spp on weight reduction in obese rats. Fifty 6-8weeks old female albino Wistar rats were grouped into two major groups; High fat diet (HFD) groups and Normal Diet (ND) groups. A concentration of 1 x 109 cfu/ml of the Lactobacillus spp was suspended daily in normal saline and orally given to rats for two weeks. The weights of both obese and non-obese rats were recorded. Results were analysed using the one-way analysis of variance. Results indicated that bodyweight increased more in the HFD groups compared to the ND groups. Analysis after probiotic treatments showed that L. plantarum (P1), and L. acidophilus + L.plantarum (PMIX) were effective in reducing the weight of the obese rats (P<0.05) while L. acidophilus (P2) was ineffective at reducing weight gain in the obese groups. The use of probiotics for weight loss can limit the adverse side effect associated with using conventionally produced anti-obesity drugs.
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