Vanillin Modulates the Status of Glycoconjugates in Favouur of Tumor Suppression in 7,12dimethylbenz[a]anthracene Induced Oral Carcinoma in Golden Syrian Hamster doi.org/10.26538/tjnpr/v5i4.4
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Abstract
Vanillin (4-hydroxy-3-methoxybenzaldehyde), the major component of natural vanilla has been reported to show antimicrobial, anti- inflammatory, hepatoprotective and anticarcinogenic activities. In this study, the modulatory efficacy of vanillin on plasma and buccal mucosa glycoconjugates has been investigated in 7,12dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Oral tumors were induced in the hamster's buccal pouch using 0.5% DMBA, in liquid paraffin (topical application, three times a week for 14 weeks). Plasma and buccal mucosa glycoconjugates status were assessed colorimetrically in the experimental hamsters. While the glyco conjugates status was found to be abnormal in both the plasma and buccal mucosa, vanillin administration orally at the dose of 200 mg/kg b.w to hamsters treated with DMBA revertedthe glycoconjugates status to near normal concentration. The results obtained clearly exhibited the protective effect of vanillin on the cell surface and circulatory glycoconjugates in DMBA induced oral carcinoma.
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