Neuroprotective Potentials of Alstonia boonei Extracts on Biochemical Markers of Brain Integrity in Experimental Rats doi.org/10.26538/tjnpr/v5i6.21

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Published: Jun 1, 2021
Keywords:
Cognitive, Neuroprotective parameters, Alstonia boonei, Wistar rats, Acetylcholinesteras

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Egba S. Ikechukwu
Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria
Okonkwo C. Onyinye
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Cross Rivers State, Nigeria
Ogbodo J. Onyebuchi
Department of Science Laboratory Technology University of Nigeria, Nsukka, Nigeria
Ezeh V. Nzubechukwu
Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria

Abstract

Alstonia boonei has been proven to be a valuable source of bioactive components. Over time, these have been used in the management of various medical conditions. This work investigated the effects of Alstonia boonei on neuroprotective parameters/markers (vitamin E, adenine deaminase and acetylcholinesterase) in mercury chloride-induced cognitive impairment and associated oxidative damages in rats. A total of 16 adult Wistar rats (male) weighing between 100 and 130 g was divided into four groups. Group 1: normal control, Group 2: mercury (II) chloride, Group 3: mercury (II) chloride + Diazepam 5 mg/kg and Group 4: mercury (II) chloride + plant extract 400 mg/kg. Result shows that eurotoxicant; mercury (II) chloride (4 mg/kg body weight; orally) caused a significant decrease in vitamin E concentration and adenine deaminase activity and increased acetycholine esterase activity, the treatment with standard drug and A. boonei extract successfully reversed the deleterious effects of the toxicant by increasing vitamin E concentration in both the cerebrum and cerebellum, reducing acetylcholine esterase activity in the cerebrum. A. boonei also significantly (p < 0.05) increased adenine deaminase activity in the cerebrum. This indicates that the A. boonei extract may possess potent neuroprotective agents whose full potentials are yet to be exploited.

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How to Cite
Ikechukwu, E. S., Onyinye, O. C., Onyebuchi, O. J., & Nzubechukwu, E. V. (2021). Neuroprotective Potentials of Alstonia boonei Extracts on Biochemical Markers of Brain Integrity in Experimental Rats: doi.org/10.26538/tjnpr/v5i6.21. Tropical Journal of Natural Product Research (TJNPR), 5(6), 1106-1109. https://tjnpr.org/index.php/home/article/view/633
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Vol. 5 No. 6 (2021): Tropical Journal of Natural Product Research
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Articles
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