Exploration of Phytochemical and Pharmacological Potentials of Canarium resiniferum Bruce ex King, an Endangered Medicinal Plant of Bangladesh doi.org/10.26538/tjnpr/v5i5.7
Main Article Content
Abstract
Canarium resiniferum Bruce ex King is an endangered medicinal plant of Bangladesh that has a lot of beneficial uses in folk medicine. The study investigated the phytochemical composition and the level of thrombolytic, anti-inflammatory, antipyretic, analgesic and hypoglycemic activities of hexane, chloroform and aqueous soluble fractions of the methanol extract of C. resiniferum leaves. Phytochemical analysis was performed by standard methods. In the thrombolytic assay, the chloroform fraction (500 µg/100 µL) of C. resiniferum exhibited significant (p<0.01) thrombolytic activity by human blood clot lysis of 57.32% as compared to the standard streptokinase (80.1%). The chloroform soluble fraction also showed the maximum anti-inflammatory potential in both egg albumin denaturation assay and human RBC membrane stabilizing assay. Yeast-induced pyrexia was utilized to evaluate the antipyretic effect of different fractions of C. resiniferum at a dose of 500 mg/kg. The temperature reducing capacity of the test samples was prominent which persisted up to 3 h of administration of test samples in mice. In tail immersion method, the hexane fraction significantly (p<0.05) increased the pain threshold with 228.57% elongation at 90 min while the chloroform fraction showed maximum 29.82% inhibition of formalin-induced licking and biting responses in mice. In the oral glucose tolerance test, the extracts (500 mg/kg) also exhibited significant blood glucose lowering effect in mice compared to the control group. The findings in the study support the rationale uses of C. resiniferum as folk medicine in Bangladesh.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Bari MS, Khandokar L, Haque E, Romano B, Capasso R, Seidel V, Haque MA, Rashid MA. Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura. J Ethnopharmacol. 2021; 271: 113834.
Sharmin T, Rashid MA. Bioactivities of stem bark of Albizia chinensis Osbeck. Merr., Chakua Koroi of Bangladesh. Afr J Pharm Pharmacol. 2020; 14(6): 179-184.
Hamilton AC. Medicinal plants, conservation and livelihoods. Biodiv Conserv. 2004; 13: 1477-1517.
Hossain MK, Alam MS. Effect of pre-sowing treatments on seed germination and seedling growth of Canarium resiniferum, a rare native tree of Bangladesh. J Environ Sci. 2017; 33(3): 226-232.
Meena D, Binaibabu N, Doss J. Future prospects for the critically endangered medicinally important species, Canarium strictum Roxb. a review. Int J Conserv Sci. 2012; 3: 231-237.
Muthuswamy R, Senthamarai R. Anti-inflammatory activity of essential oil of Canarium strictum Roxb. Iran J Pharm Sci. 2013; 9(2): 13-21.
Suruse PB, Duragkar NJ, Shivhare UD, Kale MK BS. Study of antibacterial activity of Canarium strictum gum resin. Res J Pharmacogn Phytochem. 2010; 2: 435-437.
Suruse PB, Bodele SB, Duragkarn JKM. Anti-inflammatory and analgesic activities of isolated compounds from Canarium strictum. J Cell Tiss Res. 2008; 8(3): 1481-1484.
Venkatachalapathi A, Kaffoor HA, Paulsamy S. Antipyretic activity of methanolic leaf extract of Canarium strictum Roxb. J Ayu Herb Med. 2017; 3(2): 60-62.
Islam M, Jannat T, Kuddus MR, Rashid MA, Haque MR. In vitro and In vivo evaluation of pharmacological potentials of Campsis radicans L. Clin Phytosci. 2019; 5: 42.
Ibrahim M, Hossain A, Shajib S, Rashid MA. Preliminary phytochemical and pharmacological screenings of Plumbago indica L . and Alpinia conchigera Griff . Dhaka Univ J Pharm Sci. 2018; 17(1): 73-79.
Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN. Membrane stabilizing activity-a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil. Fitoterapia 1999; 70:251-257.
Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983; 16(2):109-110.
Muhammad N, Saeed M, Khan H. Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Compl Altern Med. 2012; 12: 59.
Islam MR, Naima J, Proma NM, Hussain MS, Uddin SMN, Hossain MKH. In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract. Clin Phytosci. 2019; 5: 32.
Khatun H, Nesa L, Islam R, Ripa FA, Mamum A, Kadir S. Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice. Asian Pac J Reprod. 2014; 3(2): 121-127.
Mahmud S, Akhter S, Rahman MA, Aklima J, Akhter S, Merry SR, Jubair SM, Dash R, Emran TB. Antithrombotic effects of five organic extracts of Bangladeshi plants in vitro and mechanisms in in silico models. Evid-Based Compl Altern Med. 2015; 782742: 8.
Ali R, Hossain M, Runa JF. Evaluation of thrombolytic potential of three medicinal plants available in Bangladesh,as a potent source of thrombolytic compounds. 2014; 4(6):430-436.
Oguntibeju OO. Medicinal plants with anti-inflammatory activities from selected countries and regions of Africa. J Inflamm Res. 2018; 11: 307-317.
Anyasor GN, Okanlawon AA, Ogunbiyi B. Evaluation of anti-inflammatory activity of Justicia secunda Vahl leaf extract using in vitro and in vivo inflammation models. Clin Phytosci. 2019; 5: 49.
Naz R, Ayub H, Nawaz S, Islam ZU, Yasmin T, Bano A, Wakeel A, Zia S, Roberts TH. Antimicrobial activity, toxicity and anti-inflammatory potential of methanolic extracts of four ethnomedicinal plant species from Punjab, Pakistan. BMC Compl Altern Med. 2017; 17(1): 302.
Dangarembizi R, Erlwanger KH, Rummel C, Roth J, Madziva MT, Harden LM. Brewer’s yeast is a potent inducer of fever, sickness behavior and inflammation within the brain. Brain Behav Immun. 2018; 68(10): 211-223.
Gege-Adebayo GI, Bassi AS, Igbokwe VU, Shafe MO. Antipyretic effect of Ocimum gratissium on brewer’s yeast induced fever in wistar rats. J Med Med Sci. 2013; 4(6):247-251.
Rauf A, Jehan N, Ahmad Z, Mubarak MS. Analgesic potential of extracts and derived natural products from medicinal plants. Pain Reli- From Analg Altern Ther Rijeka: InTech. 2017; 339-351.
Chen S, Rong Y, Liu M, Cheng S, Liu X, Li X, Yu Y, Yang G and Yang X. Analgesic effects of triterpenoid saponins from Stauntonia chinensis via selective increase in inhibitory synaptic response in mouse cortical neurons.Front Pharmacol. 2018; 9(11): 1-12.
Zhao J, Xu F, Huang H, Gu Z, Wang L, Tan W, He J, Chen Y, and Li C. Antitumor and antioxidant potential of total saponins from Nigella glandulifera seeds. Evid-Based Compl Altern Med. 2013; 2013: 1-8.
Khan H, Pervaiz A, Intagliata S, Das N, Nagulapalli Venkata KC, Atanasov AG, Najda A, Nabavi SM, Wang D, Pittalà V, Bishayee A. The analgesic potential of glycosides derived from medicinal plants. Daru. 2020; 28(1): 387-401.
Bribi N. Pharmacological activity of alkaloids: A Review. Asian J Bot. 2018; 1: 1-6.
Salehi B, Ata AV, Anil Kumar N, Sharopov F, RamírezAlarcón K, Ruiz-Ortega A, Abdulmajid Ayatollahi S, Valere Tsouh Fokou P, Kobarfard F, Amiruddin Zakaria Z, Iriti M, Taheri Y, Martorell M, Sureda A, N. Setzer W, Durazzo A, Lucarini M, Santini A, Capasso R, Adrian Ostrander E, -ur-Rahman A, Iqbal Choudhary MC, Cho W, Sharifi-Rad J. Antidiabetic potential of medicinal plants and their active components. Biomol. 2019; 9(10): 551.
Njogu SM, Arika WM, Nyamai DW, Ngugi MP, Machocho AK, Ngeranwa JJN, Njagi ENM. Hypoglycemic effect of aqueous and ethyl acetate leaf extract of Maytenus putterkloides in alloxan induced diabetic mice. J Diabet Metab. 2016;7:685.