Immunomodulatory Effects of Three Species of Baccharis on Human Peripheral Blood Mononuclear Cells doi.org/10.26538/tjnpr/v5i6.12
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Abstract
Species of the genus Baccharis are medicinal plants are popularly used to treat gastrointestinal and inflammatory diseases and have demonstrated biological activities. However, studies on human cells are limited. The effects of the extracts from aerial part of B. trimera, B. punctulata, notosergila on human peripheral blood mononuclear cells (PBMCs) were assessed. B. trimera and B. punctulata decreased phytohemagglutinin (PHA)-induced lymphocyte proliferation. Also, B. punctulata downregulated the production of IFN-γ cytokine. Additionally, different compounds were identified in the extracts (from B. trimera apigenin and genkwanin, from B. punctulata trans-phytol and a di-O-caffeoylquinic acid and from B. notosergila chrysoeriol) by using liquid chromatography coupled to mass spectrometry (LCMS). Our results show that B. trimera and B. punctulata have potential anti-inflammatory activity, indicating promising use as immunomodulators.
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