Formulation and Evaluation of Two Types of Functional Beverage Granules Made of Extracts of Guava Leaves, Purple Sweet Potato and Cinnamon doi.org/10.26538/tjnpr/v5i6.7

Main Article Content

Nikmatul I. E. Jayani
Bill L. Salawane
Hendro Y. Pelopolin
Karina C. Rani

Abstract

Functional foods are bioactive compounds that have the potential to provide health benefits beyond the basic nutritional values. This study was conducted to formulate and evaluate functional beverage granules with the use of guava leaves, purple sweet potatoes, and cinnamons as functional herbal-based food. Granules from the ethanol extracts of guava leaves and purple sweet potatoes were prepared with three different ratios: Formulas 1 (3:2 %), 2 (3:2.5 %), and 3 (3:3 %). Also, ethanol extracts of guava leaves and cinnamons were formulated with three different ratios: Formulas I (3:1 %), II (3:2 %), and III (3:3 %). These granules were formulated by the wet granulation method, and then their characteristics were evaluated. The results showed that the functional beverage granules made of guava leaves and purple sweet potatoes had % fines of 1.52±0.55‒6.04±0.06, moisture contents of 1.51±0.10‒2.06±0.12%, flow rates at 9.34±0.77–10.89±0.32 g/sec, angles of repose at 29.64 ± 0.67‒30.70±1.55, compressibility index of 16.19±0.82‒17.32±3.43%, and Hausner ratio of 1.20±0.01–1.22±0.03. Meanwhile, those made of guava leaves and cinnamons had % fines of 1.63±0.49‒1.85±0.81, moisture contents of 0.71±0.10‒1.06±0.02 %, flow rates at 7.93±0.44–8.61±0.74 g/sec, angles of repose at 20.95±1.56–31.17±1.29, compressibility index of 19.56±1.32‒20.37±1.32%, and Hausner ratio of 1.24±0.02–1.25±0.02. All granule formulas containing guava leaves and purple sweet potatoes met the predefined specifications. Conversely, the granule formulas containing guava leaves and cinnamons did not meet the standard specification. 

Article Details

How to Cite
Jayani, N. I. E., Salawane, B. L., Pelopolin, H. Y., & Rani, K. C. (2021). Formulation and Evaluation of Two Types of Functional Beverage Granules Made of Extracts of Guava Leaves, Purple Sweet Potato and Cinnamon: doi.org/10.26538/tjnpr/v5i6.7. Tropical Journal of Natural Product Research (TJNPR), 5(6), 1024-1029. https://tjnpr.org/index.php/home/article/view/565
Section
Articles

References

Díaz-de-Cerio E, Verardo V, Gómez-Caravaca AM, Fernández-Gutiérrez A, Segura-Carretero A. Health effects of Psidium guajava L. Leaves: An overview of the last decade. Int J Mol Sci. 2017; 18:1-31.

Kasmawati H, Ihsan S, Munasari D, Ode Elafita W. Ethnomedicine Studies of Traditional Medicinal Plants of the Muna Tribe in the Village of Bungi Southeast Sulawesi Province of Indonesia. Int J Sci Res. 2018; 1882-1887.

Metwally AM, Omar AA, Ghazy NM, Harraz FM, el Sohafy SM. Monograph of Psidium guajava L. leaves. Pharmacogn J. 2011; 3:89-104.

Laily N, Kusumaningtyas RW, Sukarti I, Rini MRDK. The Potency of Guava Psidium Guajava (L.) Leaves as a Functional Immunostimulatory Ingredient. Procedia Chem. 2015; 14:301-307.

Dutta S. Review Article Sweet Potatoes for Diabetes Mellitus: A Systematic Review. Pharmacophore. 2015; 6(1):60-72.

Ji H, Zhang H, Li H, Li Y. Analysis on the Nutrition Composition and Antioxidant Activity of Different Types of Sweet Potato Cultivars. Food Nutr Sci. 2015; 06(01):161-167.

Li A, Xiao R, He S, An X, He Y, Wang C, Yin S, Wang B, Shi X, He J. Research advances of purple sweet potato anthocyanins: Extraction, identification, stability, bioactivity, application, and biotransformation. Molecules. MDPI. 2019; 24:1-21.

Chen CC, Lin C, Chen MH, Chiang PY. Stability and quality of anthocyanin in purple sweet potato extracts. Foods. MDPI. 2019; 8(9):1-13.

Muhammad DRA and Dewettinck K. Cinnamon and its derivatives as potential ingredient in functional food—A review. Int J Food Prop. 2017; 20:2237-2263.

Nawatila R, Pradana AT, Nabilla DA, Oktaviani FL, Efendi RN, Anjarsari AAK, Tanuwijaya CD, Putri RA. Pengembangan Granul Herbal Kumis Kucing, Temulawak, dan Pegagan dengan Pengisi Maltodextrine dan Spray Dried Lactose. Media Pharm Indon. 2020; 3:1-9.

Staniforth J. Powder flow. In: York P, Aulton M, Marriott C, Fell J, Attwood D, Pugh J, editors. The Science of Dosage Form Design Second Edition. Edinburgh: Churchill Livingstone; 2001. 197-210 p.

Gupta R, Sharma P, Garg A, Soni A, Sahu A, Rai S, Rai S, Shukla A. Formulation and evaluation of herbal effervescent granules incorporated with Calliandra haematocephala leaves. Indo Am J Pharm Res. 2013; 3(6):4366-4371.

Yulia R, Pradana AT, Sie SS, Suri FA. Formulation and physical characteristics of detam soybean (Glycine max(L.) merr) tablet with various concentration of silicon dioxide and magnesium stearate. Asian J Pharm Clin Res. 2018; 11(1):283-288.

Husni P, Fadhiilah ML, Hasanah U. Formulasi Dan Uji Stabilitas Fisik Granul Instan Serbuk Kering Tangkai Genjer (Limnocharis flava (L.) Buchenau.) Sebagai Suplemen Penambah Serat. Jurnal Ilmiah Farmasi Farmasyifa. 2020; 3(1):1-8.

Rahmawati IF, Pribadi P, Hidayat IW. Formulasi dan evaluasi granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.). Pharmaciana. 2016; 6(2):39-148.

Rani KC, Parfati N, Muarofah D, Sacharia SN. Formulasi Granul Effervescent Herba Meniran (Phyllanthus niruri L.) dengan Variasi Suspending Agent Xanthan Gum, CMC-Na, dan Kombinasi CMCNa-Mikrokristalin Selulosa. Jurnal Sains Farmasi & Klinis. 2020; 7(1):39-51.

Allen LV and Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems, Philadelphia: Wolters Kluwer. 2014. 1689-1699 p.

Carlin BA. Direct Compression and the Role of Fillerbinders. In: Augsburger LL, Hoag SW, editors. Pharmaceutical Dosage Forms - Tablets Vol. 2. New York: Informa Healthcare USA; 2008. 173-216 p.

Lachman L. Teori dan Praktek Farmasi Industri. Ed Ketiga. Jakarta: Penerbit Universitas Indonesia; 1994.400-410 p.

Kementerian Kesehatan Republik Indonesia. Farmakope Herbal Indonesia Edisi II; 2017. 181-184 p.

Febriantini D, Mulyati AH, Widiastuti D. Karakteristik Proksimat dan Organoleptik Ubi Jalar Merah (Ipomea batatas (L.) Lam.) Pada Berbagai Proses Pemasakan (Proximate and Sensory Properties of Red Sweet Potatoes (Ipomea batatas (L.) Lam.) on Various Cooking Process). Jurnal Ilmu Pertanian Indonesia. 2016; 21(1):1-6.

Zheng X, Wu F, Hong Y, Shen L, Lin X, Feng Y. Developments in taste-masking techniques for traditional Chinese medicines. Pharmaceutics. MDPI. 2018; 10:1-22

Nokhodchi A. An Overview of the Effect of Moisture on Compaction and Compression. Pharmtech. 2005; 46:46-66.

Djarot P and Badar M. Formulation and production of granule from Annona muricata fruit juice as antihypertensive instant drink. Int J Pharm Pharm Sci. 2017; 9(5):18-22.

Alyami H, Koner J, Dahmash EZ, Bowen J, Terry D, Mohammed AR. Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets. J Pharm Pharmacol. 2017; 69(7):807-822.

Hadi M, Diyah Ikasari E, Tinggi Ilmu Farmasi S, Pharmasi Y. The optimation of temperature and time of drying granule bee pollen in chewable tablet. Majalah Farmaseutik. 2014; 10:176-181.

Saad Suliman R. A. Recent Progresses and Manufacturing Techniques in Pharmaceutical Powders and Granulation. Int J Pharm Clin Res. 2019; 11(1):1-12.

Khaidir S, Murrukmihadi M, Perdana Kusuma A. Formulasi Tablet Ekstrak Kangkung Air (Ipomoea Aquatica F.) Dengan Variasi Kadar Amilum Manihot Sebagai Bahan Penghancur. Jurnal Ilmiah Farmasi. 2015; 11(1):1-8.

Bella DR. Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia Mangostana. L) Menggunakan Aerosil Dan Avicel PH 101. J Trop Pharm Chem. 2015; 3(2):131-137.

Etti CJ, Yusof YA, Chin NL, Tahir M. Effects of formulation on flowability of selected herbal powders using compendial methods and powder flow analyser. Int Food Res J. 2016; 23:225-230.