Effects of Serotonin, Melatonin, and Zinc Levels on Prolactin Hormone in Hyperprolactinemic Patients in Basrah Governorate, Iraq
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Abstract
Prolactin is a versatile hormone that plays a significant role in the metabolic, mammalian body, impacting reproductive, immunological, sexual, and other functions. It is not surprising, then, that the neuronal regulator of prolactin excretion is complex, including the coordinated actions of numerous hypothalamic nuclei. A plethora of experimental information exists on the hypothalamic control of hormonal secretion under numerous physiological stimuli. The present study was conducted to investigate the effect of serotonin, melatonin, and zinc levels on prolactin hormone in hyperprolinemic patients in Basrah Governorate, Iraq. Thirty healthy subjects (15 males and 15 females) as a control group and 47 patients (25 females and 22 males) with hyperprolactinemia were recruited from the Infertility and in vitro Fertilization Centre, in Basrah Governorate, Iraq. Blood samples were collected from the study groups. The levels of the hormone’s prolactin, serotonin, and melatonin were estimated by using the enzymatic immunoassay technique, ELISA. Zinc concentration was determined by employing the spectrophotometric method. The results revealed a significant (p<0.05) increase in prolactin levels in both male and female patients when compared to the control groups, with the increase being higher in women than in men. Also, a decrease in zinc levels in patients with hyperprolactinemia with a significant difference (p<0.05) when compared with the healthy control group was observed. Patients with hyperprolactinemia had a significant (p<0.05)increase in serotonin and melatonin hormones when compared to their control groups. The findings of this study suggest that these hormones are considered stimulating factors for the secretion of prolactin.
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