Detection of the Association between ACE Gene Polymorphism and Lipid Profiles Level in Some Iraqi Hypertensive Patients doi.org/10.26538/tjnpr/v5i6.6
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Abstract
Angiotensin-converting enzyme (ACE) plays a central role in the control of hypertension. ACE insertion/deletion (I/D) polymorphism has been reported to affect lipid profiles. There has not been any study on the influence of ACE I/D gene polymorphism on lipid levels in Iraqi hypertensive patients. The present study was therefore aimed at examining the association between ACE I/D polymorphism with hypertension and its effects on lipid levels in some Iraqi patients. Blood specimens were obtained from seventy hypertensive patients (43 males and 27 females) and forty healthy individuals with identical ages. The blood samples were divided into two parts; serum was recovered from the first part and used for estimating lipid levels. The second part of the blood samples was utilized for extracting genomic DNAs which were used to detect ACE I/D polymorphism. The results of the lipid profile analyses indicated a significant increase (p<0.01) in the treatment group compared with control group. The frequencies and odds ratio values of mutant D allele and DD genotype were significantly high (p<0.01) in the experimental group in contrast to the control group. Also, high levels of the low-density lipoprotein and triglycerides were correlated with the presence of D allele in the treatment group (p<0.05). Conclusively, the DD genotype and D allele can be considered as indicators of hypertension and disorders of lipid profiles in Iraqi population.
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