A New Biflavonoid Glycoside from the Leaves of Ziziphus mucronata Willd. (Rhamnaceae)
doi.org/10.26538/tjnpr/v2i4.3
Keywords:
Ziziphus mucronata,, Isolation,, Structure elucidation,, bis (quercetin 3-O- β-D-glucopyranoside).Abstract
A new compound was isolated from the n-butanol fraction of the crude methanol extract of the leaves of Ziziphus mucronata, a plant that is widely used in ethnomedicine to treat inflammation, diarrhoea, tumour, cough, sores, asthma, measles, fever, infections and urinary problems, amongst numerous indications. The isolation of the compound was carried out by a combination of silica gel column and sephadex gel filtration chromatography and the structure was elucidated with the help of UV, IR, and 1D, 2D -
1H and 13C NMR spectroscopic analysis. The compound, a glycoside biflavonoid, was established as bis (quercetin 3-O-β-D-glucopyranoside). The compound might be responsible for some of the observed biological activities of the plant Ziziphus mucronata.
References
Sarker S, Nahar L. Chemistry for pharmacy students: general, organic and natural product chemistry. (1st ed). England: John Wiley & Sons; 2007. 284 p.
Nishitha G, Latha AG, Tejaswini L, Mounica A, Rekha K, Reddy KN, Jyothirmayi B, Kesana SN, Unissa R. In vitro Cytotoxic Activity of Ethyl Acetate Fraction of Hibiscus vitifolius Flowers Against HeLa Cell Line. Trop J Nat Prod Res. 2018; 2(3):122-125.
Burkill HM. The useful plants of west tropical Africa. Volume 4: Royal Botanic Gardens; 1994. 95-98 p.
Abdullahi, SM, Musa, AM, Abdullahi, MI, Sani, YM, Atiku, I. Catechin from the leaf extract of Ziziphus mucronata willd. (Rhamnaceae). Nig J Pharm Sci. 2017; 16(2):1-5.
Abdullahi SM, Musa AM, Ya’u J, Magaji MG, Hassan HS, Idris AY. Phytochemical, analgesic and anti-inflammatory studies on the methanol leaf extract of Ziziphus mucronata Willd. (Rhamnaceae). Jopatrot. 2017; 6(2):120-128.
Kaleem WA, Muhammad N, Khan H, Rauf A. Pharmacological and phytochemical studies of genus Zizyphus. Middle East J Sci Res. 2014; 21:1243-12637. Silva GL, Lee I, Douglas KA. Special Problems with Extraction of Plants. In Cannell, R.J.P. (Ed.). Natural Products Isolation. New Jersey: Humana Press, 1998. 356-358 p.
Kemp W. Organic spectroscopy. United Kingdom: Palgrave Macmillan; 1991. 30 p.
Wu Y, Sun B, Huang J, Gao H, Wu L. A new flavonoid glycoside from the seeds of Fagopyrum tataricum. Asian J. Trad. Med. 2007; 2(5): 202-205.
Mabry TJ, Markham KR, Thomas MB. The systematic Identification of Flavonoids. Germany: Springer verlag; 1970. 261-294 p.
Kumar N, Singh B, Bhandari P, Gupta AP, Uniyal SK, Kaul VK. Biflavonoids from Lonicera japonica. Phytochem. 2005; 66(23):2740-2744.
Kim HP, Park H, Son KH, Chang HW, Kang SS. Biochemical pharmacology of biflavonoids: implications for anti-inflammatory action. Arch Pharm Res. 2008; 31(3):265.
Agrawal PK, Ed. Carbon-13 NMR of flavonoids. Elsevier; 2013. 49 p
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