Evaluation of the Binding Potential of Chrysophyllum albidum Seed Gum in Paracetamol Tablet Formulation

doi.org/10.26538/tjnpr/v2i3.7

Abstract

The seed gum of the endosperm of Chrysophyllum albidum has been reported to be a potential pharmaceutical excipient. The study aimed at the evaluation of the binding property of Chrysophyllum albidum seed gum (CasG) in paracetamol tablets in comparison with acacia gum (AcaG). Three batches of paracetamol granules containing CasG concentrations of 5, 10 and 15% w/w and another batch containing 10% w/w acacia gum (AcaG) were prepared using the wet granulation technique. The four batches of the granules were compressed into tablets at the same compression settings. The granules and tablets were evaluated using standard procedures.
The granule properties showed that the four batches had acceptable flow characteristics; however, the batch containing 10% w/w CasG had more comparable flow properties with the batch that had 10% w/w AcaG. Tablet properties were found to be dependent on the concentration of CasG. Tablet hardness and disintegration time increased, while tablet friability decreased with increase
in CasG concentration. Tablets with 10% w/w CasG had comparable tablet properties with those of 10% w/w AcaG and also gave the optimum tablet formulation as the hardness, friability and disintegration time were within acceptable limits. The batch with 5% w/w CasG failed friability and hardness tests while the batch of 15% w/w CasG failed disintegration time test. At a concentration of 10% w/w, CasG could be employed as a binder in paracetamol tablet formulation hence CasG could be used as a binder in tablet systems.