Uterine Contractile Activity of Extract of Icacina trichantha on Albino Non-Pregnant Rat Uterus
doi.org/10.26538/tjnpr/v2i3.3
Keywords:
Icacina trichantha,, uterine contraction,, phytochemicals,, non-pregnant rat.Abstract
The use of medicinal plants to facilitate births and control abortion among rural women is a common practice in Sub-Saharan Africa. Icacina trichantha is one of such plants used in Edo and Delta States of Nigeria for the treatment and management of threatened abortion and uterine pain by herbal practitioners. The present study was conducted to determine the uterine contractile activity of Icacina trichantha on albino non-pregnant rat uterus. The powdered plant leaves were extracted with methanol in a soxhlet apparatus. The crude extract was concentrated in a rotary evaporator at 50oC. Phytochemical screening was conducted according to standard methods and contractile activity was determined using non-pregnant female albino rat with the aid of Ugo Basile channel recorder.
Alkaloids, phenolics, eugenols and steroids were present while tannin was absent. The uterine contractile results revealed that the methanol extract of I. trichatha produced a significant (p <0.05) decrease in both oxytocin and acetylcholine-induced contractions of the rat uterus. The activity of the extract was comparable to that of salbutamol and atropine; two positive controls
that significantly (p < 0.05) relaxed the uterus.
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