Phytochemistry of Syzygium polycephalum
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Abstract
Syzygium polycephalum is a plant that grows in several parts of Indonesia and belongs to Myrtaceae family. This research aims to reveal the isolation and structure elucidation of the bioactive compounds in this plant's fruit, seeds and leaves as part of overall research on the genus Syzygium. The isolation process included extraction, separation and purification, while the structure elucidation of isolated compounds was executed using the spectroscopic method. As a result, 1,5-dimethylcitrate and trimethyl citrate were isolated from the dichloromethane extract of the fruit, while from the ethyl acetate extract of the seeds, methyl gallate and gallic acid were isolated and identified. From the dichloromethane extract of the leaves, 3,4,3'-tri-O-methylellagic acid was isolated and identified. Determination of antioxidant activity was executed using the ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) approach, with Trolox as a standard. Gallic acid showed the best antioxidant activity among the five isolated compounds with an IC50 of 29.6 g/mL. From this study, five secondary metabolites were isolated. Some showed strong activity and some were inactive as antioxidant.
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Roosita K, Kusharto CM, Sekiyama M, Fachrurozi Y, Ohtsuka R. Medicinal plants used by the villagers of a Sundanese community in West Java, Indonesia. J Ethnopharmacol. 2008; 115(1):72-81.
Irnawati I. Anthoycanin Total and Antioxidant Activity of Ruruhi (Syzygium polycephalum Merr.) Fruits. Pharmacon. 2017; 6(3):169-175.
Perdana F, Martiani I, Dhanti D. Antioxidant activity from ethanol extract of kupa leaves (Syzygium polycephalum (Miq.) Merr& LM Perry) using DPPH (2, 2-diphenyl-1-picrylhydrazil) method. J Phys Conf Ser. 2019; 1402:055086.
Juanda D, Aligita W, Elfahmi HR, Musaad S. Antioxidant and alpha glucosidase inhibition activity of kupa (Syzygium polychepalum Miq.) cortex. Int J Pharm Phytopharmacol Res. 2018; 8(3):33-38.
Tukiran T, Wardana AP, Hidajati N, Shimizu K. Chemical components and antioxidant activities of methanol extract of Syzygium polycephalum Miq. stem bark (Myrtaceae). Indian J Nat Prod Resour. 2019; 10(2):127-136.
Tukiran T, Wardhana AP, Hidajati N, Shimizu K. Two Phenolic Compounds from Chloroform Fraction of Syzygium polycephalum MIQ. Stem Bark (Myrtaceae). Molekul. 2018; 13(1):23-29.
Tukiran T, Wardana AP, Hidayati N, Shimizu K. An Ellagic Acid Derivative and Its Antioxidant Activity of Stem Bark Extracts of Syzygium polycephalum Miq.(Myrtaceae). Indones J Chem. 2018; 18(1):26-34.
Choironi NA, Insani KN, Parika D, Sunarto S, Martinus A, Fareza MS. Isolation and Characterization of Non-Phenolic Compounds from Gowok Leaves (Syzygium polycephalum Miq.). MPI. 2019; 2(3):140-145.
Jemi R, Syafii W, Febrianto F, Hanafi M. Anti-fungal Properties of Kupa Woods (Syzygium polycephalum (Mig)). Jurnal Ilmu dan Teknologi Kelautan Tropis. 2018; 8(2):93-108.
Ragasa C, Torres O, Shen CC, Lachica M, Sulit A, Chua D, Ancheta A, Ismail C, Bernaldez F, Raga D. Triterpenes from the leaves of Syzygium polycephalum, S. cumini, and S. samarangense. Chem Nat Compd. 2014; 50(5):942-944.
Bai B, Li MJ, Wang Y, Liu XH. Studies on chemical constituents of Dioscorea opposita. Zhongguo Zhong yao za zhi. 2008; 33(11):1272-1274.
Tukiran T, Mahmudah F, Hidayati N, Shimizu K.Gallic Acid: A Phenolic Acid and Its Antioxidant Activity From Stem Bark of Chloroform Extracts of Syzygium litorale(Blume) Amshoff (Myrtaceae). Molecules. 2016; 11(2):180-189.
Phongpaichit S, Nikom J, Rungjindamai N, Sakayaroj J, Hutadilok-Towatana N, Rukachaisirikul V, Kirtikara K. Biological activities of extracts from endophytic fungi isolated from Garcinia plants. FEMS Microbiol Immunol. 2007; 51(3):517-525.