In vivo Antioxidant Activity of Hydroethanol Extracts of Terminalia avicennioides (Combretaceae) in Salmonella typhi-Infected Wistar Rat’s Model doi.org/10.26538/tjnpr/v5i7.3

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Published: Jul 1, 2021
Keywords:
Terminalia avicennioides, Phytochemical, Oxidative stress, Salmonella typhi

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Louis-Claire N. Famen
Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
Benjamin T. Talom
Department of Biomedicals Sciences, Faculty of Science, The University of Ngaoundere, P.O. Box 454 Ngaoundere, Cameroon
Richard S. Tagne
Department of Biomedicals Sciences, Faculty of Science, The University of Ngaoundere, P.O. Box 454 Ngaoundere, Cameroon
Siméon P. C. Fodouop
Department of Biomedicals Sciences, Faculty of Science, The University of Ngaoundere, P.O. Box 454 Ngaoundere, Cameroon
Gabriel T. Kamsu
Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
Norbert Kodjio
Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
Alain B. Fowa
Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
Donatien Gatsing
Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon

Abstract

Infectious diseases such as typhoid fever leads to the formation of free radicals which can have a damaging effect on the body. This study evaluated the in vivo antisalmonella activity of the hydroethanol extract of Terminalia avicennioides stem bark in rats infected with Salmonella typhi (ATCC 6539), and its antioxidant activity. The S. typhi-infected rats concurrently received daily doses of T. avicennioides extract (5, 23 and 46 mg/kg) or ciprofloxacin (14 mg/kg) as positive control, for 15 days. At the end of the treatment period, the animals were sacrificed and blood, liver, kidney, heart, lung and spleen were collected for evaluation of biochemical parameters, which included assays of superoxide dismutase, catalase, peroxidase, malondialdehyde and nitric oxide, as well as biological responses. The hydroethanol extract of avicennioides bark (5, 23 and 46 mg/kg) cured the infected rats between the 8th and 11th day of treatment. The extracts also significantly reduced (p < 0.05) blood malondialdehyde and nitric oxide levels, and significantly increased (p<0.05) the activity of superoxide dismutase, catalase and peroxidase in the infected rats. Phytochemical analysis revealed the presence of flavonoids, alkaloids, phenols, saponins, anthocyanins and anthraquinones in the hydroethanol bark extract of T. avicennioides. The results show that the hydroethanol bark extract of T. vicennioides possesses antisalmonella activity and reduces the state of oxidative stress caused by S. typhi during rat’s infection. 

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Famen, L.-C. N., Talom, B. T., Tagne, R. S., Fodouop, S. P. C., Kamsu, G. T., Kodjio, N., Fowa, A. B., & Gatsing, D. (2021). In vivo Antioxidant Activity of Hydroethanol Extracts of Terminalia avicennioides (Combretaceae) in Salmonella typhi-Infected Wistar Rat’s Model: doi.org/10.26538/tjnpr/v5i7.3. Tropical Journal of Natural Product Research (TJNPR), 5(7), 1185-1191. https://tjnpr.org/index.php/home/article/view/504
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Vol. 5 No. 7 (2021): Tropical Journal of Natural Product Research
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Famen, L.-C. N., Talom, B. T., Tagne, R. S., Fodouop, S. P. C., Kamsu, G. T., Kodjio, N., Fowa, A. B., & Gatsing, D. (2021). In vivo Antioxidant Activity of Hydroethanol Extracts of Terminalia avicennioides (Combretaceae) in Salmonella typhi-Infected Wistar Rat’s Model: doi.org/10.26538/tjnpr/v5i7.3. Tropical Journal of Natural Product Research (TJNPR), 5(7), 1185-1191. https://tjnpr.org/index.php/home/article/view/504

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