The Influence of Kenikir (Cosmos caudatus Kunth) Ethanol Extract Concentrations on Peel off Gel Formula and its Anti-Aging Effect

doi.org/10.26538/tjnpr/v5i7.5

Authors

  • Bayu E. Prasetyo Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Ade Kaevin Faculty of Pharmacy, Tjut Nyak Dhien University, Medan, Indonesia
  • Fenny Hasanah Faculty of Pharmacy, Tjut Nyak Dhien University, Medan, Indonesia
  • Lia Laila Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Keywords:

Anti-aging, Cosmos caudatus Kunth, Peel off gel mask, Skin analyzer

Abstract

Anti-aging is considered as an option to slow down or prevent the natural aging process in the body, including skin area. Kenikir (Cosmos caudatus Kunth) is known for its promising potential to be developed as a natural anti-aging alternative. The purpose of this research was to evaluate the effect of various concentrations of kenikir ethanol extract on the characteristics of peel off gel mask produced and its anti-aging effects. The ethanol extract was obtained by maceration. Various concentrations of ethanol  extract (1, 3, and 5%) were inserted to the gel base containing Carbomer 940 as gelling agent and compared with the negative control. The organoleptic test, homogeneity, pH determination, drying time, irritation test and stability test were conducted to evaluate the gel characteristics. The anti-aging test was done using a skin analyzer. The results showed that all formulation had successfully produced a peel off gel mask with good characteristics which were homogenous, within range of normal skin pH (5.3 – 6), drying time of below 21 minutes, non-irritant and stable for 3 months. All formula demonstrated anti-aging effects which were pore size reduction, increase in moisture level, and reduction of dark spots and wrinkles. The results were dependent on the extract concentration. The peel off gel mask with kenikir extract was successfully developed and the highest extract concentration (5%) showed the maximum anti-aging effects. 

Author Biography

Bayu E. Prasetyo, Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

Nanomedicine Centre of Innovation Universitas Sumatera Utara, Medan, 20155, Indonesia

References

Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin Anti-aging Strategies. Dermato-Endocrinol. 2012; 4(3):308-319.

Shamsuddin AM, Sekar M, Musa AZ. Formulation and Evaluation of Antiaging Cream containing Mangiferin. Int Res J Pharm. 2018; 9(6):55-59.

Prasetyo BE, Rafika D, Laila L, Aminah F. Physical Evaluation and Anti-Aging Effect of Red Bean Ethanolic Extract (Vigna angularis (Wild.) Ohwi & Ohashi) Peel-Off Gel Mask. Open Access Maced J Med Sci. 2019; 7(22):3907-3910.

Joshue JM, Anilkumar A, Cu V, Vasudevan DT, Surendran SA. Formulation and Evaluation of Antiaging Phytosomal Gel. Asian J Pharm Clin Res. 2018; 11(3):409-422.

Masaki H. Role of antioxidants in the skin: Anti-aging effects. J Derm Sci. 2010; 58(2):85-90.

Li X. Anti-aging cosmetics and its efficacy assessment methods. IOP Conf. Ser.: Mater Sci Eng. 2015; 87(1):012043.

Ahsanuddin S, Lam M, Baron ED. Skin aging and oxidative stress. AIMS Mol Sci. 2016; 3(2):187-195.

Hafid AF, Ismail, Wardiyanto S, Tumewu L, Rahman A, Anti AW. Free-Radical Scavenging Activity Screening of Some Indonesian Plants. Int J Pharm Pharm Sci. 2014; 6(6):115-117.

Mediani A, Abas F, Khatib A, Tan CP. Cosmos Caudatus as a Potential Source of Polyphenolic Compounds: Optimisation of Oven Drying Conditions and Characterisation of Its Functional Properties. Molecules. 2013; 18:10452-10464.

Bunawan H, Baharum SN, Bunawan SN, Amin NM, Noor NM. Cosmos Caudatus Kunth: A Traditional Medicinal Herb. Global J Pharmacol. 2014; 8(3):420-426.

Ridwanto R, Lubis MS, Syahputra RA, Inriyani H. Utilisation of Biopolymer Combination as a Material for Making Gel Peel Off Mask. Proceeding of the 5th Ann Inter Sem Trends in Sci and Sci Educ. 2018; 282-294p.

Beringhs AO, Rosa JM, Stulzer HK, Budal RM, Sonaglio D. Green Clay and Aloe Vera Peel-Off Facial Masks: Response Surface Methodology Applied to the Formulation Design. Am Assoc Pharm Sci. 2013; 14(1):445-455.

Reveny J, Nazliniwaty, Umayah R. Formulation of Peel-Off Mask from Ethanol Extract of Water Spinach Leaves as AntiAging. Int J Pharm Tech Res. 2016; 9(12):554-559.

Hanum TI and Laila L. Evaluation of Anti-Aging and AntiAcne Effect of Andaliman (Zanthoxylum acanthopodium DC.) Ethanolic Extract Peel Off Gel Mask. Asian J Pharm Clin Res. 2018; 11(13):90-93.

Rieger MM. Harry's Cosmeticology. 8th ed. New York: Chemical Publishing Co. Inc., 2000. 471-483 p.

Maqlam T, Shayoub ME, Osman Z, Osman B. Formulation and evaluation of antibacterial herbal formulations containing the

aquatic ethanol extract of Kigelia africana fruits. J. Pharm Innov. 2019; 8(7):53-60.

Cahyani IM and Putri IDC. Formulation of Peel-Off Gel from Extract of Curcuma heyneana Val & Zijp Using Carbopol 940. J Pharm Med Sci. 2017; 2(2):48-51.

Aramo I. Skin and Hair Diagnosis System. Sungnam: Aram HuvisKorea Ltd., 2012.

Zhang QW, Lin LG, Cai Ye W. Techniques for extraction and isolation of natural products: a comprehensive review. Chin Med. 2018; 13:20.

Widiyantoro A and Harlia. Antioxidant Activity of Leaves Extract of Kenikir (Cosmos caudatus Kunth) with Various Extraction Methods. Indones J Pure Appl Chem. 2020; 3(1):9-14.

Mun’im A, Andriani A, Mahmudah KF, Mashita M. Screening of α-glucosidase inhibitory activity of some Indonesian

medicinal plants. Int J Med Arom Plants. 2013; 3(2):144-50.

Suhery WN and Nia A. Formulation and Evaluation of Peel-off Gel Masks from Red Rice Bran Extract with Various Kind of Bases. Int J Pharm Tech Res. 2016; 9(12):574-580.

Luthfiyana N and Nurhikma, Hidayat T. Characteristics of Peel Off Gel Mask from Seaweed (Eucheuma cottonii) Porridge. Indon Fish Proc J. 2019; 22(1):119-127.

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Published

2021-07-01

How to Cite

Prasetyo, B. E., Kaevin, A., Hasanah, F., & Laila, L. (2021). The Influence of Kenikir (Cosmos caudatus Kunth) Ethanol Extract Concentrations on Peel off Gel Formula and its Anti-Aging Effect: doi.org/10.26538/tjnpr/v5i7.5. Tropical Journal of Natural Product Research (TJNPR), 5(7), 1196–1200. Retrieved from https://tjnpr.org/index.php/home/article/view/502