Anti-seizure activity of Extract of Jatropha gossypiifolia Linn (Euphorbiaceae)
doi.org/10.26538/tjnpr/v2i2.8
Keywords:
Seizure,, Jatropha gossypiifolia,, Strychnine,, 4-aminopyridine.Abstract
The leaves of Jatropha gossypiifolia has been widely used for the treatment of epilepsy and childhood convulsions in ethnomedicinal practice of Northern Nigeria. In this study, we investigated the anti-seizure claim of this plant part using established scientific protocols. Phytochemical screening and acute toxicity evaluation of the methanol leaf extract were performed while maximal electroshock-induced seizures in cockerels (MEST), pentylenetetrazole (PTZ), strychnine (STN) and 4-aminopyridine (4-AP) induced seizure models were employed in mice. The methanol leaf extract contains cardiac glycosides, steroids, triterpenes, tannins and
flavonoids, while the median lethal dose of the extract was estimated to be 1131 mg/kg. In the anti-seizure studies, the extract at all the tested doses (75, 150 and 300 mg/kg) did not delay the recovery time of convulsed cockerels in MEST model nor delay the mean onset of seizures in PTZ and 4-AP models in mice in comparison with controls. Conversely, the extract at 150 mg/kg dose
significantly (p ≤ 0.05) delayed the mean onset of seizures in mice in STN model compared to control treatments. In conclusion, this study provided the possible pharmacological basis for the use of Jatropha gossypiifolia leaf in treating seizure conditions
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