Pharmacological and Nutritional Properties of <i>Rosmarinus officinalis/i>: A Comprehensive Review

Main Article Content

Abdelhay Benyaich
Mustapha Aksissou

Abstract

Rosmarinus officinalis, commonly called rosemary is an aromatic plant native to the Mediterranean region. It has been employed in traditional medicine for its diverse therapeutic benefits. Contemporary research has validated its pharmacological potentials, attributing its efficacy to its rich phytochemical profile. This review explores the pharmacological and nutritional properties of rosemary, with particular focus on its bioactive compounds, including carnosic acid, carnosol, and rosmarinic acid. A comprehensive literature search across multiple databases yielded a robust dataset on the composition and biological activities of rosemary. The nutritional profile, encompassing essential oils, flavonoids, triterpenic acids, vitamins, minerals, and macronutrients, was meticulously examined. In addition, the review elucidated advanced extraction techniques for optimal bioactive compound recovery. By unraveling the mechanisms underlying the health-promoting effects of rosemary, this study provided adequate information that could guide the clinical applications and nutritional use of rosemary especially within the context of functional foods.


 

Article Details

How to Cite
Benyaich, A., & Aksissou, M. (2024). Pharmacological and Nutritional Properties of <i>Rosmarinus officinalis/i>: A Comprehensive Review. Tropical Journal of Natural Product Research (TJNPR), 8(9), 8258–8268. https://doi.org/10.26538/tjnpr/v8i9.2
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References

Delgado A, Gonçalves S, Romano A. Mediterranean diet: the role of phenolic compounds from aromatic plant foods. Foods. 2023; 12(4):0840. https://doi.org/10.3390/foods12040840

Becer E, Altundağ EM, Güran M, Vatansever HS, Ustürk S, Hanoğlu DY, Başer KHC. Composition and antibacterial, anti-inflammatory, antioxidant, and anticancer activities of Rosmarinus officinalis L. essential oil. South Afr J Bot. 2023; 160:437-445. https://doi.org/10.1016/j.sajb.2023.07.028

Li Pomi F, Papa V, Borgia F, Vaccaro M, Allegra A, Cicero N, Gangemi S. Rosmarinus officinalis and skin: antioxidant activity and possible therapeutical role in cutaneous diseases. Antioxidants. 2023; 12(3): 680. https://doi.org/10.3390/antiox12030680

El Boukhari R and Fatimi A. A review of the patentability of rosemary-derived drugs and bioactive compounds. Drugs Drug Candidates. 2023; 2(1):172-188. https://doi.org/10.3390/ddc2010011

Habtemariam S. Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol. Biomed. 2023; 11(2):545. https://doi.org/10.3390/biomedicines11020545

Kasmi M, Diakite A, Barrijal S, Essalmani H. Chemical composition and antifungal activity of essential oils of Rosmarinus officinalis L. and Salvia officinalis L. against Botrytis cinerea Pers. Trop J Nat ProdRes. 2024; 8(1):5897-5907. https://doi.org/10.26538/tjnpr/v8i1.27

Pradeep VR, Menaka S, Suresh V, Jayaraman S. Anticancer effects of Rosmarinus officinalis leaf extract on KB cell lines. Cureus. 2024; 16(2):e54031. https://doi.org/10.7759/cureus.54031

Khalil DY and Hassan OM. Antioxidant and antibacterial properties of Rosmarinus officinalis essential oil. J Univ Anbar Pure Sci. 2024; 18(1):131-139. https://doi.org/10.37652/juaps.2024.146060.1177

Memariani Z, Moeini R, Hamedi SS, Gorji N, Mozaffarpur SA. Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review. J Thromb Thrombolysis. 2018; 45:158-179. https://doi.org/10.1007/s11239-017-1580-3

Alvarado-García PAA, Soto-Vásquez MR, Rosales-Cerquin LE, Benites SM, Cubas-Romero TL, Jara-Aguilar DR, Alfaro-Beltrán IM. Effect of Rosmarinus officinalis essential oil on anxiety, depression, and sleep quality. Pharmacogn J. 2023; 15(2):343-349. https://doi.org/10.5530/pj.2023.15.52

Chebaibi M, Bousta D, Chbani L, Touiti N, Achour S. Acute toxicity of plants mixture used in traditional treatment of edema and colic renal in Morocco. Sci Afr. 2019; 6:e00152. https://doi.org/10.1016/j.sciaf.2019.e00152

Nakisa N. Therapeutic potential of rosemary (Rosmarinus officinalis L.) on sports injuries: a review of patents. Res J Pharmacogn. 2022; 9(3):71-83. https://doi.org/10.22127/rjp.2022.329094.1844

Hamed AN, Attia E, Desoukey SY. A review on various classes of secondary metabolites and biological activities of Lamiaceae (Labiatae) (2002-2018). J Adv Biomed Pharm Sci. 2021; 4(1):16-31. https://doi.org/10.21608/jabps.2020.38318.1095

Hasan MN and Sultan SM. Effects of Fe and GA3 on growth and oil characteristic of rosemary plant (Rosmarinus officinalis L.). Plant Cell BiotechnolMol Biol. 2020; 21(40):55-63. http://archive.sdpublishers.com/id/eprint/2212/

Pistelli L, Giovanelli S, D'Angiolillo F, Karkleva K, Leonardi M, Ambryszewska K, Pistelli L. Antioxidant activity of several essential oils from different Rosmarinus officinalis cultivars grown in Sanremo (Italy). Nat Prod Commun. 2018; 13(9):1167-1170. https://doi.org/10.1177/1934578X1801300917

Hammer M and Junghanns W. Rosmarinus officinalis L.: Rosemary. In: Novak J, Blüthner WD. (eds) Medicinal, Aromatic and StimulantPlants.2020;12:501-521. https://doi.org/10.1007/978-3-030-38792-1_15

Agrahari S, Kesharwani V, Kushwaha N. A review on modern extraction techniques of herbal plants. Int J Pharmacogn. 2021; 8(5):177-188. https://ijpjournal.com/wp-content/uploads/2021/06/2-Vol.-8-Issue-5-May-2021-IJP-RE-322.pdf

Patel MR, Dave KR, Patel PR. A review on different extraction method of plants: Innovation from ancient to modern technology. Int J Biol Pharm Allied Sci. 2021; 10(12):511-527. https://doi.org/10.31032/IJBPAS/2021/10.12.1044

Satyal P, Jones TH, Lopez EM, McFeeters RL, Ali NA, Mansi I, Al-Kaf AG, Setzer WN. Chemotypic characterization and biological activity of Rosmarinus officinalis. Foods. 2017; 6(3):20. https://doi.org/10.3390/foods6030020

Farhadi F, Baradaran Rahimi V, Mohamadi N, Askari VR. Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases. Biofactors. 2023; 49(3): 478-501. https://doi.org/10.1002/biof.1929

Luo C, Zou L, Sun H, Peng J, Gao C, Bao L, Sun S. A review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseases. Front Pharmacol. 2020; 11:153. https://doi.org/10.3389/fphar.2020.00153

Jeevalatha A, Kalaimathi RV, Basha AN, Kandeepan C, Ramya S, Loganathan T, Jayakumararaj R. Profile of bioactive compounds in Rosmarinus officinalis. J Drug Deliv Ther. 2022; 12(1):114-122. https://doi.org/10.22270/jddt.v12i1.5189

Oualdi I, Diass K, AziziSeddine, Dalli M, Touzani R, Gseyra N, Yousfi EB. Rosmarinus officinalis essential oils from Morocco: new advances on extraction, GC/MS analysis, and antioxidant activity. Nat Prod Res. 2022; 37(12):2003-2008. https://doi.org/10.1080/14786419.2022.21115611

González-Minero FJ, Bravo-Díaz L, Ayala-Gómez A. Rosmarinus officinalis L.(Rosemary): an ancient plant with uses in personal healthcare and cosmetics. Cosmetics. 2020; 7(4):77. https://doi.org/10.3390/cosmetics7040077

Elsherif KM, Alhlbad EAA, Ewlad-Ahmed AM. Phytochemical Screening, antioxidant activity, and Mineral Profiling of Rosmarinus officinalis L. from Msallata Region (Libya). Sci J Fac Sci-Sirte Univ. 2023; 3(2):9-17. https://doi.org/10.37375/sjfssu.v3i2.1543

Patrignani F, Prasad S, Novakovic M, Marin PD, Bukvicki D. Lamiaceae in the treatment of cardiovascular diseases. Front Biosci. 2021; 26(4):612-643. https://dx.doi.org/10.2741/4909

Ben Abdelmalek Y, Smeti S, Essid I, Yagoubi Y, Tibaoui S, Atti N. The effect of Rosemary (Rosmarinus officinalis L.) distillation residues and linseed supply on fatty acid profile, meat colour, lipid oxidation and sensorial and hygienic quality of cull Barbarine ewes' meat. J AnimPhysiolAnimNutr. 2020; 104(5):1294-1304. https://doi.org/10.1111/jpn.13383

Afonso MS, de O Silva AM, Carvalho EB, Rivelli DP, Barros SB, Rogero MM, Mancini-Filho J. Phenolic compounds from Rosemary (Rosmarinus officinalis L.) attenuate oxidative stress and reduce blood cholesterol concentrations in diet-induced hypercholesterolemic rats. NutrMetabol. 2013; 10:1-9. https://doi.org/10.1186/1743-7075-10-19

Ribeiro-Santos R, Carvalho-Costa D, Cavaleiro C, Costa HS, Albuquerque TG, Castilho MC, Sanches-Silva A. A novel insight on an ancient aromatic plant: The rosemary (Rosmarinus officinalis L.). Trends Food Sci Technol. 2015; 45(2):355-368. https://doi.org/10.1016/j.tifs.2015.07.015

Rathore S. Mukhia S. Kapoor S. Bhatt V. Kumar R. Kumar R. Seasonal variability in essential oil composition and biological activity of Rosmarinus officinalis L. accessions in the western Himalaya. Sci Rep. 2022; 12(1):3305. https://doi.org/10.1038/s41598-022-07298-x

Sakar EH, Zeroual A, Kasrati A, Gharby S. Combined effects of domestication and extraction technique on essential oil yield, chemical profiling, and antioxidant and antimicrobial activities of rosemary (Rosmarinus officinalis L.). J Food Biochem. 2023; 1: 6308773. https://doi.org/10.1155/2023/6308773

Benissa Z, Dumas F, Fakhfakh N, Zouari S. Chemical variability and antioxidant activities of spontaneous and cultivated Rosmarinus officinalis essential oils according to the geographical origin of their exploited organs. J Essent Oil Res. 2024; 36(1):67-78. https://doi.org/10.1080/10412905.2023.2300365

Allegra A, Tonacci A, Pioggia G, Musolino C, Gangemi S. Anticancer activity of Rosmarinus officinalis L.: mechanisms of action and therapeutic potentials. Nutrients. 2020; 12(6):1739. https://doi.org/10.3390/nu12061739

Gonçalves C, Fernandes D, Silva I, Mateus V. Potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. Molecules. 2022; 27(3):609. https://doi.org/10.3390/molecules27030609

Laftouhi A, Mahraz MA, Hmamou A, Assouguem A, Ullah R, Bari A, Taleb M. Analysis of Primary and Secondary Metabolites, Physical Properties, Antioxidant and Antidiabetic Activities, and Chemical Composition of Rosmarinus officinalis Essential Oils under Differential Water Stress Conditions. ACS Omega. 2024; 9(14):16656-16664. https://doi.org/10.1021/acsomega.4c00653

Joshua MT. Phytochemical Constituents of Rosmarinus officinalis Linn. and Their Associated Role in the Management of Alzheimer’s Disease. In: Herbal Medicine Phytochemistry: Applications and Trends. Cham: Springer International Publishing. 2023; Pp.1-24. https://doi.org/10.1007/978-3-031-21973-3_14-1

Sasaki K, Ferdousi F, Fukumitsu S, Kuwata H, Isoda H. Antidepressant-and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system. Biomed Pharmacother. 2021; 144:112291. https://doi.org/10.1016/j.biopha.2021.112291

de Macedo LM, Santos ÉM, Militão L, Tundisi LL, Ataide JA, Souto EB, Mazzola PG. Rosemary (Rosmarinus officinalis L., syn SalviarosmarinusSpenn.) and its topical applications: A review. Plants. 2020; 9(5):651. https://doi.org/10.3390/plants9050651

Rahmani H, Ghanbariasad A, Meshkibaf MH, Molazade A, Heiran R, Safari M, Osanloo M. Chitosan nanoparticles containing α-pinene and Rosmarinus officinalis L. essential oil: effects on human Melanoma cells’ viability and expression of apoptosis-involved genes. Polym Bull. 2024; 81(3):2505-2523. https://link.springer.com/article/10.1007/s00289-023-04839-w

Ahmed HM and Babakir-Mina M. Investigation of rosemary herbal extracts (Rosmarinus officinalis) and their potential effects on immunity. Phytother Res. 2020; 34(8):1829-1837. https://doi.org/10.1002/ptr.6648

Moore J, Yousef M, Tsiani E. Anticancer effects of rosemary (Rosmarinus officinalis L.) extract and rosemary extract polyphenols. Nutrients. 2016; 8(11):731. https://doi.org/10.3390/nu8110731

Von Schönfeld C, Huber R, Trittler R, Kammerer B, Garcia-Käufer M, Gründemann C. Rosemary has immunosuppressant activity mediated through the STAT3 pathway. Complement Ther Med. 2018; 40:165-170. https://doi.org/10.1016/j.ctim.2018.03.004

Nadeem M, Imran M, Gondal TA, Imran A, Shahbaz M, Amir RM, Martins N. Therapeutic potential of rosmarinic acid: A comprehensive review. Appl Sci. 2019; 9(15):3139. https://doi.org/10.3390/app9153139

Jaglanian A, Termini D, Tsiani E. Rosemary (Rosmarinus officinalis L.) extract inhibits prostate cancer cell proliferation and survival by targeting Akt and mTOR. Biomed Pharmacother. 2020; 131:110717. https://doi.org/10.1016/j.biopha.2020.110717

da Silva Bomfim N, Kohiyama CY, Nakasugi LP, Nerilo SB, Mossini SAG, Romoli JCZ, Machinski Jr M. Antifungal and antiaflatoxigenic activity of rosemary essential oil (Rosmarinus officinalis L.) against Aspergillus flavus. Food AdditContam Part A. 2020; 37(1): 153-161. https://doi.org/10.1080/19440049.2019.1678771

Takayama KS, Monteiro MC, Saito P, Pinto IC, Nakano CT, Martinez RM, Georgetti SR. Rosmarinusofficinalisextract-loaded emulgel prevents UVB irradiation damage to the skin. An Acad Bras Cienc. 2022; 94(4):e20201058. https://doi.org/10.1590/0001-3765202220201058

Francolino R, Martino M, Caputo L, Amato G, Chianese G, Gargiulo E, Feo VD. Phytochemical constituents and biological activity of wild and cultivated Rosmarinus officinalis hydroalcoholic extracts. Antioxidants. 2023; 12(8):1633. https://doi.org/10.3390/antiox12081633

Ijaz S, Iqbal J, Abbasi BA, Ullah Z, Yaseen T, Kanwal S, Cho WC. Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications. Biomed Pharmacother. 2023; 162:114687. https://doi.org/10.1016/j.biopha.2023.114687

Zhao J, Xu L, Jin D, Xin Y, Tian L, Wang T, Wang J. Rosmarinic acid and related dietary supplements: Potential applications in the prevention and treatment of cancer. Biomol. 2022; 12(10):1410. https://doi.org/10.3390/biom12101410

Kamli MR, Sharaf AAM, Sabir JS, Rather IA. Phytochemical screening of Rosmarinus officinalis L. as a potential anticholinesterase and antioxidant-medicinal plant for cognitive decline disorders. Plants. 2022; 11(4):514. https://doi.org/10.3390/plants11040514

De Araujo JT, de Oliveira PF, Sá PS, Távora NP, Pinheiro AV, Trindade TB, Pinheiro MT. Effect of essential oil of Rosmarinus officinalis L. (Rosemary) on the healing of cutaneous lesions in mice. J Chem Pharm Res. 2017; 9(5):381-386. https://www.researchgate.net/profile/Ana-Rita-Barcessat-2/publication/343949335_Effect_of_Essential_Oil_of_Rosmarinus_officinalis_L_Rosemary_on_the_Healing_of_Cutaneous_Lesions_in_Mice/links/5f4a7507299bf13c50513a1d/Effect-of-Essential-Oil-of-Rosmarinus-officinalis-L-Rosemary-on-the-Healing-of-Cutaneous-Lesions-in-Mice.pdf

Khezri K, Farahpour MR, Mounesi Rad S. Accelerated infected wound healing by topical application of encapsulated Rosemary essential oil into nanostructured lipid carriers. Artif Cells NanomedBiotechnol. 2019; 47(1):980-988. https://doi.org/10.1080/21691401.2019.1582539

Erkan İE and Aşcı ÖA. Studies on antimicrobial, antifungal and antioxidant properties of rosemary: a review. Turk J Agric Food Sci Technol. 2020; 8(12):2708-2715. https://doi.org/10.24925/turjaf.v8i12.2708-2715.3948

İnce B, Bilgen F, Gündeşlioğlu AÖ, Dadacı M, Kozacıoğlu S. Use of systemic Rosmarinus officinalis to enhance the survival of random-pattern skin flaps. Balkan Med J. 2016; 33(6):645-651. https://doi.org/10.5152/balkanmedj.2016.150981

Khatoon R, Alam MA, Sharma PK. A comprehensive study of pharmacological behaviors, nano-formulations, and applications of rosemary. Nat Prod J. 2021; 11(5):629-647. https://doi.org/10.2174/2210315510999201104165058

Montenegro L, Pasquinucci L, Zappalà A, Chiechio S, Turnaturi R, Parenti C. Rosemary essential oil-loaded lipid nanoparticles: In vivo topical activity from gel vehicles. Pharmaceutics. 2017; 9(4):48. https://doi.org/10.3390/pharmaceutics9040048

Eid AM, Jaradat N, Issa L, Abu-Hasan A, Salah N, Dalal M, Zarour A. Evaluation of anticancer, antimicrobial, and antioxidant activities of rosemary (Rosmarinus officinalis) essential oil and its Nanoemulgel. Eur J Integr Med. 2022; 55:102175. https://doi.org/10.1016/j.eujim.2022.102175

Bouammali H, Zraibi L, Ziani I, Merzouki M, Bourassi L, Fraj E, Touzani R. Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study. Plants. 2023; 13(1):89. https://doi.org/10.3390/plants13010089

Konstantinou EK, Panagiotopoulos AA, Argyri K, Panoutsopoulos GI, Dimitriou M, Gioxari A. Molecular pathways of rosmarinic acid anticancer activity in triple-negative breast cancer cells: a literature review. Nutrients. 2023; 16(1):2. https://doi.org/10.3390/nu16010002

Sirajudeen F, Malhab LJB, Bustanji Y, Shahwan M, Alzoubi KH, Semreen MH, Abu-Gharbieh E. Exploring the potential of rosemary derived compounds (rosmarinic and carnosic acids) as cancer therapeutics: current knowledge and future perspectives. BiomolTher (Seoul). 2024; 32(1):38. https://doi.org/10.4062/biomolther.2023.054

Borrás-Linares I, Pérez-Sánchez A, Lozano-Sánchez J, Barrajón-Catalán E, Arráez-Román D, Cifuentes A, Segura-Carretero A, Micol V. A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells. Food ChemToxicol. 2015; 80:215-222. https://doi.org/10.1016/j.fct.2015.03.013

Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum Nutr. 2010; 65(2):158-163. https://doi.org/10.1007/s11130-010-0166-4

Chan EWC, Wong SK, Chan HT. An overview of the chemistry and anticancer properties of rosemary extract and its diterpenes. J HerbmedPharmacol. 2021; 11(1):10-19. https://doi.org/10.34172/jhp.2022.02

Kadasah SF and Radwan MO. Overview of ursolic acid potential for the treatment of metabolic disorders, autoimmune diseases, and cancers via nuclear receptor pathways. Biomedicines. 2023; 11(10):2845. https://doi.org/10.3390/biomedicines11102845

Song X, Sui X, Jiang L. Protection Function and Mechanism of Rosemary (Rosmarinus officinalis L.) Extract on the Thermal Oxidative Stability of Vegetable Oils. Foods. 2023; 12(11):2177. https://doi.org/10.3390/foods12112177

Ibrahim N, Abbas H, El-Sayed NS, Gad HA. Rosmarinus officinalis L. hexane extract: phytochemical analysis, nanoencapsulation, and in silico, in vitro, and in vivo anti-photoaging potential evaluation. Sci Rep. 2022; 12(1):13102. https://doi.org/10.1038/s41598-022-16592-7

Miraj S. An evidence-based review on herbal remedies of Rosmarinus officinalis. Pharm Lett. 2016; 8(19):426-436. https://core.ac.uk/download/pdf/143840598.pdf

Cuevas-Durán RE, Medrano-Rodríguez JC, Sánchez-Aguilar M, Soria-Castro E, Rubio-Ruíz ME, Del Valle-Mondragón L, Ibarra-Lara L. Extracts of Crataegusoxyacantha and Rosmarinusofficinalisattenuate ischemic myocardial damage by decreasing oxidative stress and regulating the production of cardiac vasoactive agents. Int J Mol Sci. 2017; 18(11):2412. https://doi.org/10.3390/ijms18112412

Chávez-Delgado EL and Jacobo-Velázquez DA. Essential oils: recent advances on their dual role as food preservatives and nutraceuticals against the metabolic syndrome. Foods. 2023; 12(5):1079. https://doi.org/10.3390/foods12051079

Hashemi SMB, Gholamhosseinpour A, Barba FJ. Rosmarinus officinalis L. essential oils impact on the microbiological and oxidative stability of Sarshir (Kaymak). Molecules. 2023; 28(10):4206. https://doi.org/10.3390/molecules28104206

Al Zuhairi JJMJ, Kashi FJ, Rahimi-Moghaddam A, Yazdani M. Antioxidant, cytotoxic and antibacterial activity of Rosmarinus officinalis L. essential oil against bacteria isolated from urinary tract infection. Eur J Integr Med. 2020; 38:101192. https://doi.org/10.1016/j.eujim.2020.101192

Pereira PS, Maia AJ, Tintino SR, Oliveira-Tintino CDDM, Raulino ISDS, Vega MC, da Silva TG. Trypanocide, antileishmania and cytotoxic activities of the essential oil from Rosmarinus officinalis L in vitro. Ind Crops Prod. 2017; 109:724-729. https://doi.org/10.1016/j.indcrop.2017.09.030

Ekambaram SP, Paramasivam S, Perumal SS, Dhakshinamurthy SS. Rosmarinus officinalis L.: A Source of Potential Antimicrobial Agents for Combating Antimicrobial Resistance. Nanobiolett. 2024; 13(1):45. https://nanobioletters.com/wp-content/uploads/2024/06/LIANBS131.045.pdf

Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomed Pharmacother. 2017; 86:441-449. https://doi.org/10.1016/j.biopha.2016.12.049

El-Mernissi Y, Zouhri A, Labhar A, El Menyiy N, Ahari MH, El Barkany S, Amhamdi H. Indigenous knowledge of the traditional use of aromatic and medicinal plants in Rif Mountains Ketama District. Evid Based Complement Alternat Med. 2023; 2023(1):3977622. https://doi.org/10.1155/2023/3977622

Andrade JM, Faustino C, Garcia C, Ladeiras D, Reis CP, Rijo P. Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity. Future Sci OA. 2018; 4(4):FSO283. https://doi.org/10.4155/fsoa-2017-0124

Rahbardar MG and Hosseinzadeh H. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iran J Basic Med Sci. 2020; 23(9):1100. https://doi.org/10.22038/ijbms.2020.45269.10541

Widyowati R, Pratama RR, Sholikhah I, Jain SK. Herbal Medicine and Rheumatic Disorders Management and Prevention. In: Herbal Medicine Phytochemistry: Applications and Trends. Cham: Springer International Publishing; 2024. Pp. 723-762. https://link.springer.com/referenceworkentry/10.1007/978-3-031-43199-9_26

Kabubii ZN, Mbaria JM, Mathiu PM, Wanjohi JM, Nyaboga EN. Diet Supplementation with Rosemary (Rosmarinus officinalis L.) Leaf Powder Exhibits an Antidiabetic Property in Streptozotocin-Induced Diabetic Male Wistar Rats. Diabetology. 2024; 5(1):12-25. https://doi.org/10.3390/diabetology5010002

Pengelly A, Snow J, Mills SY, Scholey A, Wesnes K, Butler LR. Short-term study on the effects of rosemary on cognitive function in an elderly population. J Med Food. 2012; 15(1):10-17. https://doi:10.1089/jmf.2011.0005

Farr SA, Niehoff ML, Ceddia MA, Herrlinger KA, Lewis BJ, Feng S, Welleford A, Butterfield DA, Morley JE. Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice. PhysiolBehav. 2016; 15:328-338. https://doi.org/10.1016/j.physbeh.2016.08.013

Park DH, Park SJ, Kim JM, Jung WY, Ryu JH. Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances. Fitoterapia. 2010; 81: 644-648. https://doi.org/10.1016/j.fitote.2010.03.010

Song H, Xu L, Zhang R, Cao Z, Zhang H, Yang L, Guo Z, Qu Y, Yu J. Rosemary extract improves cognitive deficits in a rat model of repetitive mild traumatic brain injury associated with reduction of astrocytosis and neuronal degeneration in hippocampus. Neurosci Lett. 2016; 27:95-101. https://doi.org/10.1016/j.neulet.2016.04.048

El-Demerdash FM, El-Sayed RA, Abdel-Daim MM. Hepatoprotective potential of Rosmarinus officinalis essential oil against hexavalent chromium-induced hematotoxicity, biochemical, histological, and immunohistochemical changes in male rats. Environ SciPollut Res. 2021; 28:17445-17456. https://doi.org/10.1007/s11356-020-12126-8

Asgari M, Kazemi M, Sourastani MM, Sharififard M. Chemical analysis of Eucalyptus and Rosemary essential oils using gas chromatography-mass spectrometry (GC-MS) and evaluation of their toxicity against the most common urban pest. Anal Methods Environ Chem J. 2023; 6(03):89-102. https://www.amecj.com/article_194373_fc71da8c395017c16b7b4e9f53cdd691.pdf