Profile of Micronutrients, Electrolytes, Haematology and CD4 Count in HIV Infected Subjects on Highly Active Antiretroviral Therapy
doi.org/10.26538/tjnpr/v2i1.9
Keywords:
HIV, HAART,, Micronutrients,, HaematologyAbstract
Human Immunodeficiency Virus (HIV) infection compromises the immune status, diminishes micronutrients availability and causes electrolyte imbalance in individuals. Highly Active Antiretroviral therapy (HAART) is currently used in the management of HIV patients. This work was designed to determine the profile of micronutrients, electrolytes, haematology and CD4 Count in HIV Infected Subjects on HAART. One hundred and sixty-three (thirty-six males and one hundred and twenty-seven females) subjects of whom one hundred and eleven (twenty-five males and eighty-six females) were HIV positive (grouped as Pre-HAART subjects). Fifty-two (eleven males and forty-one females) HIV- negative controls were used in this study. Blood samples (10mL) were collected by veni-puncture from Pre-HAART subjects and the control group. 5 mL was added to clean sterile bottle to yield serum for micronutrient and electrolyte determination while 5 mL were added to EDTA bottles for haematological and CD4 count. The HIV subjects were then placed on HAART for six months. Blood samples were then collected. Our findings showed a significant (p ≤ 0.05) increase in CD4 count and the haematological parameters of HAART subjects when compared to pre-HAART HIV subjects. The same results were obtained for the
serum levels of vitamins A and C, zinc, copper, selenium and potassium ion. However, the serum levels of vitamin E, sodium and chloride ions did not show any significant different (p ≥ 0.05) between the pre-HAART and HAART subjects. Mineral supplements rich in vitamin E, sodium and chloride ions may be required in combination with HAART in HIV management.
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