Fmrfamide Mitigated MDMA (3, 4- Methylenedioxymethamphetamine)/Tramadol-Induced Testicular Toxicity in Wistar Rat https://doi.org/10.26538/tjnpr/v8i7.34

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Published: Aug 1, 2024
Keywords:
MDMA, Tramadol, FMRFamide, Testicular Toxicity, sperm cells, reproductive health

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Opeyemi A. Adetunji
Department of Anatomy, School of Basic Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Bayo O. Adeoye
Department of Biochemistry, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
Oyedayo P. Akano
Department of Physiology, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
Ayodeji D. Adeoye
Department of Physiology, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
Iyanuoluwa O. Adebayo
Department of Physiology, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
Adetomiwa E. Adeogun
Department of Physiology, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
Sanmi T. Ogunsanya
Department of Anatomy, School of Basic Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Nnenna L. Nwobi
Department of Chemical Pathology, Faculty of Basic Clinical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ogun State, Nigeria.
Chigbogu J. Nwobi
Department of Anatomy, School of Basic Medical Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Omowumi O. Akinnawo
Department of Biochemistry, School of Basic Medic al Sciences, Babcock University, Ogun State, Nigeria.
Samson O. Oyewumi
Department of Physiology, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.
Oluwapelumi M. Ajiboye
Department of Basic Sciences, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Kehinde A. Ademoye
Department of Physiological Sciences, Obafemi Awolowo University, Ile-Ife, Osun-State, Nigeria.
Oluwaseun B. Osundina
Department of Biochemistry, Osun State University, Osogbo, Nigeria.
Goodness O. Olatinwo
Department of Physiology, School of Basic Medical Sciences, Babcock University, Ogun State, Nigeria.

Abstract

MDMA (3,4-methylenedioxymethamphetamine) and tramadol are central nervous system stimulants known for inducing emotional communion and socializing effects. FMRFamide, an RFamide peptide isolated from mollusks, plays diverse roles in physiological processes. This study aimed to evaluate FMRFamide's impact on testicular toxicity induced by MDMA/tramadol in Wistar rats. Thirty male Wistar rats were divided into six groups (n=5). Group A served as the control, Group B received 2 mg/kg FMRFamide for two consecutive days. Groups C, D, and E received MDMA/tramadol (20 mg/kg) for ten days, while Group F received the same dosage along with FMRFamide. Sperm analysis, biochemical, and histological assessments were conducted. The results revealed significant body weight loss, decreased sperm count and motility, increased abnormal sperm formation, and reduced serum LH, FSH, and Testosterone levels. Inducible Nitric Oxide Synthase (iNOS) expression was intensified in Groups A, B, D, and F. Notably, FMRFamide administration attenuated the adverse effects of MDMA/tramadol-induced testicular toxicity, suggesting a potential therapeutic role in safeguarding male reproductive health. These findings highlight the importance of further exploring FMRFamide's protective mechanisms and its potential application in mitigating drug-induced reproductive toxicity.

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How to Cite
Adetunji, O. A., Adeoye, B. O., Akano, O. P., Adeoye, A. D., Adebayo, I. O., Adeogun, A. E., Ogunsanya, S. T., Nwobi, N. L., Nwobi, C. J., Akinnawo, O. O., Oyewumi, S. O., Ajiboye, O. M., Ademoye, K. A., Osundina, O. B., & Olatinwo, G. O. (2024). Fmrfamide Mitigated MDMA (3, 4- Methylenedioxymethamphetamine)/Tramadol-Induced Testicular Toxicity in Wistar Rat: https://doi.org/10.26538/tjnpr/v8i7.34 . Tropical Journal of Natural Product Research (TJNPR), 8(7), 7869-7875. https://tjnpr.org/index.php/home/article/view/4452
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Vol. 8 No. 7 (2024): Tropical Journal of Natural Product Research (TJNPR)
Section
Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Adetunji, O. A., Adeoye, B. O., Akano, O. P., Adeoye, A. D., Adebayo, I. O., Adeogun, A. E., Ogunsanya, S. T., Nwobi, N. L., Nwobi, C. J., Akinnawo, O. O., Oyewumi, S. O., Ajiboye, O. M., Ademoye, K. A., Osundina, O. B., & Olatinwo, G. O. (2024). Fmrfamide Mitigated MDMA (3, 4- Methylenedioxymethamphetamine)/Tramadol-Induced Testicular Toxicity in Wistar Rat: https://doi.org/10.26538/tjnpr/v8i7.34 . Tropical Journal of Natural Product Research (TJNPR), 8(7), 7869-7875. https://tjnpr.org/index.php/home/article/view/4452

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