Aphrodisiac Effect of Methanol Hypocotyls Extracts of Borassus aethiopum Mart. in Male Wistar Rats
doi.org/10.26538/tjnpr/v5i10.24
Keywords:
Aphrodisiac, Borassus aethiopum, Male sexual behaviour, Testosterone, Traditional medicineAbstract
Borassus aethiopum is a tropical plant found in most parts of West Africa. The fruits and hypocotyl are used in traditional herbal medicine for the treatment of various diseases (malaria, bronchitis, skin infections and infertility) and nutritional purposes. In many parts of Nigeria especially in Northern Nigeria, it is used as an aphrodisiac agent in males. This study evaluated the aphrodisiac effect of the methanol extract of the hypocotyl of Borassus aethiopum in male Wistar rats. Adult male Wistar rats were divided into five groups and administered orally with the plant extract at doses of 250, 500 and 1000 mg/kg body weights. Sildenafil citrate (5 mg/kg) and distilled water (1 mL/kg) were administered orally, and served as positive and negative controls, respectively. The acute toxicological evaluation of the plant extract was based on behavioural changes and mortality. Sexual behavioural parameters (mounting and intromission frequencies, and ejaculatory latencies) were observed on days 1, 7 and 28. Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and gonadotrophin releasing hormones (GnRH) were measured. Acute toxicity studies of the plant extract did not show any behavioural changes in the animals and there was no mortality. The extract significantly increased mounting and intromission frequencies (p<0.05) and decreased mounting and intromission latencies in a dose-dependent manner on days 1, 7 and 28 (p<0.05). It also prolonged ejaculatory latency. The extract was also noted to increase GnRH, serum testosterone and gonadotrophins. The results suggest that the methanol hypocotyl extract of Borassus aethiopum possess aphrodisiac properties.
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