Therapeutic Effects of Y10 Capsule on Male Patients with Semen Quality Impairment
doi.org/10.26538/tjnpr/v5i10.17
Keywords:
Semen quality impairment, Cornu cervi parvum, Cordyceps militaris, VietnamAbstract
Traditional medicine has been effectively used in treating male infertility and other diseases of men. The purpose of the study is to evaluate the safety and effectiveness of Y10 capsules used in improving spermatogenesis in male patients with semen quality impairment. The composition of the capsule includes Velvet antler (Cornu cervi parvum) and Cordyceps militaris (Ophiocordyceps sinensis) in a ratio of 5: 3. Thirty patients with impaired semen quality were recruited for this study from the Embryology Research and Training Center, Military Medical Academy, Vietnam, from October 2017 to December 2017. Each patient participating in the study used four Y10 capsules/day, two hours after meals, continuously for two months. The study results reveal that Y10 capsules effectively regulated LH and FSH secretion, increased serum testosterone levels, sperm count and quality in patients with semen quality impairment. Also, Y10 capsules did not cause unwanted effects nor changes in the biochemical and haematological parameters of the patients surveyed. This study concluded that treatment with Y10 capsules improved semen quality in the study group and could therefore be used to manage patients with semen quality impairment in Vietnam.
References
Rowe PJ, Comhaire FH, Hargreave TB, Mahmoud AM. WHO manual for the standardized investigation and diagnosis of the infertile male: Cambridge university press; 2000.
Kamel RM. Management of the infertile couple: an evidence-based protocol. Reprod Biol Endocrinol.
;8(1):1-7.
Sun H, Gong T-T, Jiang Y-T, Zhang S, Zhao Y-H, Wu Q-J. Global, regional, and national prevalence and disabilityadjusted life-years for infertility in 195 countries and territories, 1990–2017: results from a global burden of disease study, 2017. Aging (Albany NY). 2019;11(23):10952.
Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13(1):1-9.
Punab M, Poolamets O, Paju P, Vihljajev V, Pomm K, Ladva R, Korrovits P, Laan M. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod. 2017;32(1):18-31.
Vuong N TL, Duong DV, Thang BM, Hop TV, Anh TQ,. Fine needle aspiration biopsy of the epididymis in maleinfertility (Sinh thiết hút kim nhỏ mào tinh trong vô sinh nam). HCMC Med J. 2007;11.
Thao NT. Infertility situation in Thanh Hoa province (Thực trạng vô sinh tại tỉnh Thanh Hóa). The 9th Vietnam-France Asia-Pacific Obstetrics and Gynaecology Conference. 2011. 16-23 p.
Carlsen E, Giwercman A, Keiding N, Skakkebæk NE. Evidence for decreasing quality of semen during past 50 years. Br Med J. 1992;305(6854):609-613.
Öztekin Ü, Caniklioğlu M, Sarı S, Selmi V, Gürel A, Işıkay L. Evaluation of male infertility prevalence with clinical outcomes in middle Anatolian region. Cureus. 2019; 11(7):e5122.
Durairajanayagam D. Lifestyle causes of male infertility. Arab J Urol. 2018;16(1):10-20.
Jiang D, Coscione A, Li L, Zeng B-Y. Effect of Chinese herbal medicine on male infertility. Int Rev Neurobiol. 2017;135:297-311.
Jo J and Jerng UM. The effects of traditional Korean medicine in infertile male patients with poor semen quality: A retrospective study. Eur J Integr Med. 2016;8(1):36-40.
Sohrabvand F, Mahroozade S, Bioos S, Nazari SM, Dabaghian FH. Improvement in sperm parameters with traditional Iranian remedy: A case report. J Evid-Based Compl Altern Med. 2017;22(2):223-226.
Jaradat N and Zaid AN. Herbal remedies used for the treatment of infertility in males and females by traditional healers in the rural areas of the West Bank/Palestine. BMC Compl Altern Med. 2019;19(1):1-12.
Zhou SH, Deng YF, Weng ZW, Weng HW, Liu ZD. Traditional Chinese medicine as a remedy for male
infertility: a review. World J Mens Health. 2019;37(2):175-185.
Abarikwu SO, Onuah CL, Singh SK. Plants in the management of male infertility. Androl. 2020;52(3):e13509.
Amano T, Hirata A, Namiki M. Effects of Chinese herbal medicine on sperm motility and fluorescence spectra parameters. Arch Androl. 1996; 37(3):219-224.
Furuya Y, Akashi T, Fuse H. Effect of Bu-zhong-yi-qi-tang on seminal plasma cytokine levels in patients with idiopathic male infertility. Arch Androl. 2004; 50(1):11-14.
Ghazeeri GS, Awwad JT, Alameddine M, Younes ZM, Naja F. Prevalence and determinants of complementary and alternative medicine use among infertile patients in Lebanon: a cross sectional study. BMC Compl Altern Med. 2012;12(1):1-9.
Park HJ, Choe S, Park NC. Effects of Korean red ginseng on semen parameters in male infertility patients: a randomized, placebo-controlled, double-blind clinical study. Chin J Integr Med. 2016; 22(7):490-495.
Wang J, Chen C, Jiang Z, Wang M, Jiang H, Zhang X. Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage. Syst Biol Reprod Med. 2016;62(4):249-257.
Xiao X, Xu S, Li L, Mao M, Wang J, Li Y, Wang Z, Ye F, Huang L. The effect of velvet antler proteins on cardiac microvascular endothelial cells challenged with ischemiahypoxia. Front Pharmacol. 017;8:601.
Le MH, Nguyen HN, Pham XP, Nguyen DB. Study of acute toxicity and semi-toxicity of Y10 capsule actor on experimental organisms (Nghiên cứu độc tính cấp và độc tính bán trường diễn của viên nang Y10 trên động vật thực nghiệm). J Vietnam Med (Tạp chí Y học Việt Nam). 2018;456(1):152-158.
Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, Haugen TB, Kruger T, Wang C, Mbizvo MT, Vogelsong KM. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010; 16(3):231-245.
Pham TMD. Physiology (Sinh lý học): Medical publishing company (Nhà xuất bản Y học); 2011; 475.
Nguyen TN. Clinical andrology (Nam khoa lâm sàng): Ho Chi Minh City general publishing company. 2013; 395.
Le MH, Nguyen HN, Pham XP, Nguyen DB,. Study on the effect of improving spermatogenesis of Y10 capsules on experimental animals (Nghiên cứu tác dụng cải thiện khảnăng sinh tinh của viên nang Y10 trên động vật thực nghiệm). J Trad Mil Med. 2018; 3:6-13.
World Health Organization. WHO laboratory manual for the examination and processing of human semen: World Health Organization; 2010.
Doan MT. Effect of Hoi xuan hoan on sperm motility in patients with infertility, impaired spermatogenesis (Tác dụng của hồi xuân hoàn trên tinh trùng sống, tinh trùng di động ở bệnh nhân vô sinh suy giảm tinh trùng). J Tradit Mil Med. 2017; 3:39-43.
Li N, Liu J, Zhang H. Comparison of chemical constituents of Cordyceps militaris and Cordyceps sinensis (蛹虫草与冬虫夏草化学成分比较). J Jilin Agric Univ. 1995; S1:80-83.
Hu T, Tao R, Su F, Zhang J. Overview of research on antler's chemical constituents and medicinal effects. J Econ Zool. 2015;19(3):156-162.
Wong WY, Flik G, Groenen PM, Swinkels DW, Thomas CM, Copius-Peereboom JH, Merkus HM, SteegersTheunissen RP. The impact of calcium, magnesum, zinc, and copper in blood and seminal plasma on semen parameters in men. Reprod Toxicol. 2001;15(2):131-136.
Colagar AH, Marzony ET, Chaichi MJ. Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr Res. 2009; 29(2):82-88.
Sundaram V, Srinivas M, Gurunathan J, Rao K, Maniyan RP, Balasundaram S. Influence of trace elements and their correlation with semen quality in fertile and infertile subjects. Turk J Med Sci. 2013; 43(6):1000-1007.
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