Topical Antimicrobial Microparticle-Based Polymeric Materials for Burn Wound Infection doi.org/10.26538/tjnpr/v5i10.1

Main Article Content

Tristiana Erawati
Rezky D. Fitriani
Dewi M. Hariyadi

Abstract

Microparticles are one of the delivery systems which protect drugs from the harsh environments and also can stabilize drugs or eliminate discrepancies. The aim of this study was to discuss topical microparticle delivery system which contains natural oils for burn wounds and also to classify burns and wound healing process. This scoping review consists of 50 publications from periods between 2016 and 2020 which resulted from the extraction of 63 publications from search engines using various keywords. Data of publications that met the inclusion and exclusion criteria were extracted manually. Most publications presented on burn wound treatment used microparticles containing synthetic drugs and natural oils. The review also pointed at a wide variety of topical product dosage forms related to formulations that range in consistency from liquid to semi-solid preparations, but the most popular product is the semi-solid preparations. The use of natural oils in topical microparticles using natural or synthetic polymers provides more advantages and is recommended for drug or cosmetic development specifically in wound care. 

Article Details

How to Cite
Erawati, T., D. Fitriani, R., & M. Hariyadi, D. (2021). Topical Antimicrobial Microparticle-Based Polymeric Materials for Burn Wound Infection: doi.org/10.26538/tjnpr/v5i10.1. Tropical Journal of Natural Product Research (TJNPR), 5(10), 1694-1702. https://tjnpr.org/index.php/home/article/view/368
Section
Articles

References

Lengyel M, Szabó NK, Antal V, Laki AJ, Antal I. Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery. Sci Pharm. 2019; 87(20):1-31.

Gattani YS. Floating Multiparticulate Drug Delivery Systems: An overview Int J Pharm Bio Sci. 2010; 6(2):35-40.

Kumar BP, Chandiran IS, Bhavya B, Sindhuri M. Microparticulate Drug Delivery System: A Review. Indian J Pharm Sci Res. 2011; 1(1):19-37.

Degim Z. Use of Microparticulate Systems to Accelerate Skin Wound Healing. J Drug Target. 2008; 16(6):437-448.

McDougal WS, Slade CL, Pruitt Jr BA. Manual of Burns. Springer-Verlag. 1987; 1-250p.

Hall C, Hardin C, Corkins CJ, Alisha Z, Jiwani AZ, Fletcher J, Carlsso A, Chan R. Pathophysiologic Mechanisms and Current Treatments for Cutaneous Sequelae of Burn Wounds. Compr Physiol. 2018; 8(1):371-405.

Caló E and Khutoryanskiy VV. Biomedical Applications of Hydrogels: A Review of Patents and Commercial Products. Eur Polym J. 2015; 65:252-267.

Degim Z, Celebi N, Alemdaroglu C, Deveci M, Ozturk S, Ozogul C. Evaluation of Chitosan Gel Containing Liposome‐Loaded Epidermal Growth Factor on Burn Wound Healing. Int Wound J. 2011; 8(4):343-354.

Aderibigbe BA and Buyana B. Alginate in Wound Dressings. Pharmaceut. 2018; 10(42):1-19.

Toussaint J, Chung WT, Clain SM, Raut V, Singer AJ. Optimal Timing for Early Excision in A Deep Partial Thickness Porcine Burn Model. J Burn Care Res. 2017; 38(1):e352-e358.

Avsar U, Zekai Halici Z, Akpinar E, Avsar MYU,Harun U, Bayraktutan AHTZ. The Effects of Argan Oil in Seconddegree Burn Wound Healing in Rats. Ostomy Wound Manag. 2016; 62(3):26-34.

Groeber F, Holeiter M, Hampel M, Hinderer S, Layland KS. Skin Tissue Engineering - In vivo and In vitro Applications. Adv Drug Deliv Rev. 2011; 63(4-5):352-366.

Dai NT, Williamson MR, Khammo N, Adams EF, Coombes AGA. Composite Cell Support Membranes Based on Collagen and Polycaprolactone for Tissue Engineering of Skin. Biomater. 2003; 25(18):4263-4271.

Wasef LG, Shaheen HM, El-Sayed YS, Shalaby TIA, Samak DH, El-Hack MEA, Al-Owaimer A, Saadeldin IM, El-mleeh A, Ba-Awadh H, Swelum AA. Effects of Silver Nanoparticles on Burn Wound Healing in A Mouse Model. Biol Trace Elem Res. 2019; 193(2):456-465.

Jahromi MAM, Zangabad PS, Basri SMM, Zangabad KS, Ghamarypour A, Aref AR, Karimi M, Hamblin MR. Nanomedicine and Advanced Technologies for Burns: Preventing Infection and Facilitating Wound Healing. Adv

Drug Deliv Rev. 2018; 1(123):33-64.

Yildirimer L, Thanh NTK, Seifalian AM. Skin Regeneration Scaffolds: A Multimodal Bottom-Up Approach. Trends Biotechnol. 2012; 30(12):638-648.

Pereira RF, Barrias CC, Granja PL, Bartolo PJ. Advanced Biofabrication Strategies for Skin Regeneration and Repair. Nanomed. 2013; 8(4):603-621.

Gong CY, Wu OJ, Wang YJ, Zhang DD, Luo F, Wei YO, Qian ZY. A Biodegradable Hydrogel System Containing Curcumin Encapsulated in Micelles for Cutaneous Wound Healing. Biomater. 2013; 34(27):6377-6387.

Dai T, Huang YY, Sharma SK, Hashmi JT, Kurup DB, Hamblin MR. Topical antimicrobials for burn wound infections. Rec Pat Antiinfect Drug Discov. 2010; 5(2):124-151.

Simões D, Miguel SP, Ribeiro MP, Coutinho P, Mendonça AG, Correia IJ. Recent Advances on Antimicrobial Wound

Dressing: A review. Eur J Pharm Biopharm. 2018; 127:130-141.

Wolcott RD, Hanson JD, Rees EJ, Koenig LD, Phillips CD, Wolcott RA, Cox SB, White JS. Analysis of The Chronic Wound Microbiota of 2,963 Patients by 16S rDNA Pyrosequencing. Wound Repair Regen. 2016; 24(1):163-174.

Jaloob AAA. Antibacterial activity of an aqueous extracts of Alkanna tinctoria roots against drug resistant aerobic pathogenic bacteria isolated from patients with burns infections. Rom J. 2018; 7:e0104

Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn Wound Infections. Clin Microbiol Rev. 2006; 19(2):403-434.

Saito A, Miyazaki H, Fujie T, Ohtsubo S, Kinoshita M, Saitoh D, Takeoka S. Therapeutic Efficacy of An antibiotic-Loaded Nanosheet in A Murine Burn-Wound InfectionModel. Acta Biomater. 2012; 8:2932-2940.

Garg T, Rath G, Goyal AK. Comprehensive Review on Additives of Topical Dosage Forms for Drug Delivery. Drug Deliv. 2015; 22(8):969-987.

Wang W, Lu KJ, Yu CH, Huang QL, Du YZ. Nano-drug Delivery Systems in Wound Treatment and Skin

Regeneration. J Nanobiotechnol. 2019; 17(82):1-15.

Saporito F, Sandri G, Bonferoni MC, Rossi S, Boselli C, Cornaglia AI, Mannucci B, Grisoli P, Vigani B, Ferrari F. Essential Oil-Loaded Lipid Nanoparticles for Wound Healing. Int J Nanomed. 2018; 13:175-186.

Pachuau L. Recent Developments in Novel Drug Delivery Systems for Wound Healing. Expert Opin Drug Deliv. 2015; 12(12):1744-7593.

Prasad BSG, Gupta VRM, Devanna N, Jayasurya K, Microspheres as Drug Delivery System–A review. J. Glob.Trends Pharm Sci. 2014; 5(3):1961-1972.

Wu J, Zheng Y, Song W, Luan J, Wen X, Wu Z, Chen X, Wang Q, Guo S. In situ Synthesis of Silver-Nanoparticles/Bacterial Cellulose Composites for SlowReleased Antimicrobial Wound Dressing. Carbohydr Polym.

; 102:762-771.

Gainza G, Villullas S, Pedraz JL, Hernandez RM, Igartua M.Advances in Drug Delivery Systems (DDSs) to Release Growth Factors for Wound Healing and Skin Regeneration. Nanomed Nanotechnol Biol Med. 2015; 11(6):1551-1557.

Xu HL, Chen PP, ZhuGe DL, Zhu QY, Jin BH, ShenBX, Xiao J, Zhao YZ. Liposomes with Silk Fibroin Hydrogel Core to Stabilize bFGF and Promote the Wound Healing of Mice with Deep Second-Degree Scald. Adv Healthc Mater. 2017; 6(19):1-13.

Manca ML, Matricardi P, Cencetti C, Peris JE, Melis V, Carbone C, Escribano E, Zaru M, Fadda AM, Manconi M. Combination of Argan Oil and Phospholipids for The Development of An Effective Liposome-Like Formulation Able to Improve Skin Hydration and Allantoin Dermal Delivery. Int J Pharm. 2016; 505(1-2):204-211.

Zhao Y, Qiu Y, Wang H, Chen Y, Jin S, Chen S. Preparation of Nanofibers with Renewable Polymers and Their Application in Wound Dressing. Int J Polym Sci. 2016; 4672839:1-17.

Park JW, Hwang SR, Yoon IS. Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration. Molecules. 2017; 22(8):1259.

Ghorbanzadeh M, Farhadian N, Golmohammadzadeh S, Karimi M, Ebrahimi M. Formulation, Clinical and Histopathological Assessment of Microemulsion Based Hydrogel for UV Protection of Skin. Coll Surf B Biointerf.

; 179:393-404.

Garbuio DC, Zamarioli CM, de Melo MO, Campos PMBGM, de Carvalho EC, de Freitas LAP. Safety of A Formulation Containing Chitosan Microparticles with Chamomile: Blind Controlled Clinical Trial. Rev Lat Am Enfermagem. 2018; 26:e3075.

Zia T, Usman M, Sabir A, Shafiq M, Khan RU. Development of Inter-Polymeric Complex of Anionic Polysaccharides, Alginate/k-Carrageenan Bio-platform for Burn Dressing. Int J Biol Macromol. 2020; 157: 83–95.

Fumakia MD and Ho EA. Nanoparticles Encapsulated with LL37 and Serpin A1 Promotes Wound Healing and Synergistically Enhances Antibacterial Activity. Mol Pharm. 2016; 13(7):2318-2331.

Mohseni M, Shamloo A, Aghababaie Z, Afjoul H, Abdi S, Moravvej H, Vossoughi M. A comparative Study of Wound

Dressings Loaded with Silver Sulfadiazine and Silver Nanoparticles: In vitro and In vivo Evaluation. Int J Pharm. 2019; 564:350-358.

Oryan A, Alemzadeh E, Moshiri A. Burn Wound Healing: Present Concepts, Treatment Strategies and Future Directions. J Wound Care. 2017; 26(1):5-19.

El-Assri EM, Eloutassi N, El Barnossi A, Bakkari F, Hmamou A, Bouia. Wild Chamomile (Matricaria recutita L) from the Taounate Province, Morocco:Extraction and Valorisation of the Antibacterial Activity of its Essential Oils. Trop J Nat Prod Res. 2021; 5(5):883-888.

Afshar M, Ghaderi R, Zardast M, Delshad P. Effects of Topical Emu Oil on Burn Wounds in the Skin of Balb/c Mice. Dermatol Res Pract. 2016; 6419216:1-6.

Bayir Y, Un H, Ugan RA, Akpinar E, Cadirci E, Calik I, Halici Z. The Effects of Beeswax, Olive Oil and Butter Impregnated Bandage on Burn Wound Healing. BURNS. 2019; 4(5):1410-1417.

Li HL, Deng YT, Zhang ZR, Fu QR, Zheng YH, CaoXM, Nie J, Fu LW, Chen LP, Xiong YX, Shen DY, ChenQX. Evaluation of Effectiveness in A Novel Wound Healing Ointment-Crocodile Oil Burn Ointment. Afr J Trad Compl Altern Med. 2017; 14(1):62-72.

Shanmugarajan TS, Selvan NK, Uppuluri VNVA, Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model. Int J Low Extrem Wounds. 2020; 1534734620921629.

Jopke K, Sanders H, White-Traut R. Use of Essential Oils Following Traumatic Burn Injury: A Case Study. [published

correction appears in J Pediatr Nurs. 2019; 44:139]. J Pediatr Nurs. 2017; 34:72-77.

Calixto G, Yoshii AC, Rocha e Silva H, Cury BSF, Chorilli M. Polyacrylic Acid Polymers Hydrogels Intended to Topical

Drug Delivery: Preparation and Characterization. Pharm Dev Technol. 2014; 20(4):490-496.

Kim H, Makin I, Skiba J, Ho A, Housler G, Stojadinovic. Antibacterial Efficacy Testing of a Bioelectric Wound Dressing Against Clinical Wound Pathogens. Open Microbiol J. 2014; 8:15-21.

Bainbridge P. Wound Healing and The Role of Fibroblasts. J Wound Care. 2013; 22(8):407-412.