Haematological and Biochemical Examination of Pulcherrimin A isolated from Caesalpinia pulcherrima stem bark doi.org/10.26538/tjnpr/v5i11.20
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Abstract
Caesalpinia pulcherrima has been utilised in the treatment of gastritis inflammation, diarrhoea dysentery, flatulence, ulcers, hepatitis, uterine dysfunction, rheumatism, haemorrhages and many other infections. The study evaluated the haematological and biochemical effects of pulcherrimin A isolated from C. pulcherrima stem bark. The compound, pulcherrimin A was administered to Wistar rats at doses of 2, 4 and 8 mg/kg body weight (bw) respectively for 28 days. The total blood count, total cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma lutamyltranspeptidase (GGT), total protein and total bilirubin were evaluated. The results showed a significant difference in white blood cell count at 2 mg/kg for female rats. Red blood cells and haemoglobin for both sexes appeared normal relative to control. The changes observed for platelets in all treated groups for both sexes were not significantly different from the control p˃0.05). The liver enzymes for the female rats appeared normal at all treatment doses, however, the glutamyltranspeptidase in male rats significantly increased at 2 mg/kg. The triglyceride and very low-density lipoproteins significantly decreased (p<0.05) for the female rats at 4 mg/kg. Findings from this study showed that pulcherrimin A have potential beneficial effects to reduce triglycerides and could facilitate the prevention of heart and liver related diseases.
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