Xanthine Oxidase Inhibitory Activity of Xanthones from <i>Calophyllum pseudomole</i> P. F. Stevens

http://www.doi.org/10.26538/tjnpr/v8i1.31

Authors

  • Ratih D. Saputri Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
  • Tukiran Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
  • Suyatno Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
  • First A. Wati Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
  • Shod A. Dzulkarnain Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
  • Mufidatuz Zakiyah Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
  • Tjitjik S. Tjahjandarie Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
  • Mulyadi Tanjung Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia

Keywords:

xanthine oxidase, caloxanthone L, ananixanthone, xanthone, Calophyllum pseudomole

Abstract

The genus Calophyllum (Calophyllaceae) is a plant proven to produce various xanthones, chromanoic acids, and 4-phenyl coumarins. This study aims to determine the xanthine oxidase inhibitory activity of xanthones from Calophylum pseudomole P.F. Stevens. Two xanthones, ananixanthone (1) and caloxanthone L (2), were isolated from Calophyllum pseudomole stem barks. The structures of both xanthones were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1-2 showed xanthine oxidase inhibitory activity with an IC50 of 15.05 and 17.7 μM, respectively, and were categorized as potent.

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Published

2024-02-01

How to Cite

Saputri, R. D., Tukiran, Suyatno, Wati, F. A., Dzulkarnain, S. A., Zakiyah, M., … Tanjung, M. (2024). Xanthine Oxidase Inhibitory Activity of Xanthones from <i>Calophyllum pseudomole</i> P. F. Stevens: http://www.doi.org/10.26538/tjnpr/v8i1.31. Tropical Journal of Natural Product Research (TJNPR), 8(1), 5932–5935. Retrieved from https://tjnpr.org/index.php/home/article/view/3416

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