Sponge-Based Ecofriendly Antifouling: Field Study on Nets, Molecular Docking with Agelasine Alkaloids

http://www.doi.org/10.26538/tjnpr/v8i1.29

Authors

  • Walter Balansa Department of Fisheries and Maritime Technology, Politeknik Negeri Nusa Utara, Kepulauan Sangihe, North Sulawesi, 95812. Indonesia
  • Riyanti Faculty of Fisheries and Marine Science, Jenderal Soedirman University, Purwokerto 53122, Indonesia
  • Usy N. Manurung Department of Agribusiness, Universitas Terbuka, South Tanggerang, 15415. Indonesia
  • Aprelia M. Tomasoa Department of Fisheries and Maritime Technology, Politeknik Negeri Nusa Utara, Kepulauan Sangihe, North Sulawesi, 95812. Indonesia
  • Novriyandi Hanif Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University (Bogor Agri-cultural University), Bogor 16680, Indonesia
  • Frets J. Rieuwpassa Department of Fisheries and Maritime Technology, Politeknik Negeri Nusa Utara, Kepulauan Sangihe, North Sulawesi, 95812. Indonesia
  • Till F. Schäberle Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, Germany

Keywords:

Agelas nakamurai, agelasines, acetylcholinesterase, Antifouling

Abstract

Biofouling poses a significant threat to fisheries and maritime sectors, capable of damaging ship hulls, mariculture facilities, and marine structures. Despite the effectiveness of tributyl tin (TBT)-based antifouling in solving biofouling problems, it threatens the marine environment and human health, necessitating the exploration of ecofriendly antifouling agents. Marine sponges have evolved unique antifouling strategies that may contain potential solutions to this problem. Hence, an epoxy resin coating enriched with powder from the sponge Agelas nakamurai underwent field testing on polyethylene nets. Analysis of variance (ANOVA) demonstrated that nets pre-treated with 100, 200, and 300 mg/mL of the epoxy resin and sponge powder mix had a significant effect on biofouling growth (P < 0.05). Post-hoc Tukey’s test indicated that the 100 mg/mL treatment significantly differed from other treatments. Since the authors previously characterized and predicted the presence of agelasines A-F (1-6) and agelasidine A (7) from the same sponge using NMR/LC-MS and MS-MS annotation, the currently studied A. nakamurai contains the same molecules. Molecular docking studies identified agelasines A-F and agelasidine A as promising acetylcholinesterase (AChE) inhibitors, rivaling or surpassing the AChE specific inhibitors, such as synoxazolidinones A (8) and C (9), and the antifouling agents Seanin_211 (10) and Irgarol_1501 (11). In silico ADME-T and TEST analyses on compounds 1-11 indicated that, while agelasines A-F need further optimization, agelasidine A was the most promising compound identified as potential antifouling agent in this research. This study marks the initial step in evaluating agelasines and other marine-derived molecules as eco-friendly antifouling agents

Author Biography

Till F. Schäberle, Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, Germany

Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, 35392 Giessen, Germany.

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Published

2024-02-01

How to Cite

Balansa, W., Riyanti, Manurung, U. N., Tomasoa, A. M., Hanif, N., Rieuwpassa, F. J., & Schäberle, T. F. (2024). Sponge-Based Ecofriendly Antifouling: Field Study on Nets, Molecular Docking with Agelasine Alkaloids: http://www.doi.org/10.26538/tjnpr/v8i1.29. Tropical Journal of Natural Product Research (TJNPR), 8(1), 5913–5924. Retrieved from https://tjnpr.org/index.php/home/article/view/3414