The Therapeutic Potential of Aceh Patchouli Oil (Pogostemon cablin Benth.) in Enhancing Full-Thickness Wound Healing in Mice http://www.doi.org/10.26538/tjnpr/v8i1.19
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Abstract
Patchouli (Pogostemon cablin) oil is widely recognized for antifungal, anti-inflammatory, and antibacterial properties. This oil also has the potential to expedite collagen production and facilitate epithelialization, which are essential for wound healing. Furthermore, epithelialization comprises the formation of epithelial cells at wound edges, typically in 3 to 14 days after the injury. Several reports have shown that this process is facilitated by the presence of bioactive components, such as patchouli alcohol, β-patchoulene, β-farnesene, α-guanine, flavonoids, and saponins from patchouli oil. Therefore, this study aims to determine the effect of Aceh patchouli oil on epithelialization in full-thickness wound of Mus musculus. A total of 28 male mice received incision wound and were divided into four groups, which were given crude patchouli oil (CPO) (Group 1), light fraction of patchouli (CPO1) (Group 2), heavy fraction of patchouli (CPO2) (Group 3), and lanolin (Control/Group 4). Transparent dressings were then used for the daily wound care regimen, followed by comprehensive histopathological examinations to assess the outcomes after 15 days. The results showed that the average thickness of the skin epithelium formed with the application of CPO, CPO1, CPO2, and control was 128.4 μ, 127.7 μ, 84.9 μ, and 126.0 μ, respectively. ANOVA analysis showed a remarkable increase in epithelial thickness in groups 1 and 2 compared to 3. This showed that the light fraction of patchouli oil had significant potential for enhancing wound healing compared to heavy fraction.
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