Exploring the Phytochemical Composition and Pharmacological Activities of Cerbera manghas and Cerbera odollam: A Comprehensive Review http://www.doi.org/10.26538/tjnpr/v8i1.1

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Published: Feb 1, 2024
Keywords:
Cerbera,, Cerbera manghas,, Cerbera odollam,, Pharmacological activities,, Phytochemicals

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Auliya Ilmiawati
Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor, Indonesia
Ummahatul Mujahidah
Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor, Indonesia
Arinana
Department of Forest Products, Faculty of Forestry and Environment, IPB University, Bogor, Indonesia
Irmanida Batubara
Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor, Indonesia
Waras Nurcholis
Tropical Biopharmaca Research Center, IPB University, Bogor, Indonesia

Abstract

Cerbera manghas and C. odollam, often perceived as similar species, exhibit distinct physical characteristics and phylogenetic classifications. Despite their reputation as poisonous plants, both species have diverse benefits and are potential sources of pharmacological compounds. This report comprehensively summarizes the compounds identified within the genus Cerbera, coupled with reported bioactivities. Over 100 compounds, including phenolics, flavonoids, terpenoids, and steroids, have been isolated from C. manghas and C. odollam. Cardiac glycosides (steroids) are the predominant compounds in these species and demonstrate robust cytotoxic activity.


Furthermore, both plants show promise as antioxidants and antimicrobial agents, and exhibit insecticidal, termiticidal, and larvicidal properties. This review consolidates the current understanding of the phytochemical and pharmacological attributes of C. manghas and C. odollam.

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How to Cite
Ilmiawati, A., Mujahidah, U., Arinana, Batubara, I., & Nurcholis, W. (2024). Exploring the Phytochemical Composition and Pharmacological Activities of Cerbera manghas and Cerbera odollam: A Comprehensive Review: http://www.doi.org/10.26538/tjnpr/v8i1.1. Tropical Journal of Natural Product Research (TJNPR), 8(1), 5715-5726. https://tjnpr.org/index.php/home/article/view/3364
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Vol. 8 No. 1 (2024): Tropical Journal of Natural Product Research (TJNPR)
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biographies

Auliya Ilmiawati, Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor, Indonesia

Tropical Biopharmaca Research Center, IPB University, Bogor, Indonesia

Irmanida Batubara, Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor, Indonesia

Tropical Biopharmaca Research Center, IPB University, Bogor, Indonesia

Waras Nurcholis, Tropical Biopharmaca Research Center, IPB University, Bogor, Indonesia

Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor, Indonesia

References

Quigley DTG, Fenwick D.C erbera sp. (Apocynaceae) drift mesocarps: first record from British waters and a summary of previous records from north-western Europe. Cah Biol Mar. 2019; 60:419-423. Doi: 10.21411/CBM.A.A9AA3201

Ruekert LF, Cunningham EA, Naqvi H. Cerbera odollam: a case report of attempted suicide by pong pong. J. Psychiatr Pract. 2019; 25(3):219-221. Doi: 10.1097/PRA.0000000000000391.

Maharana PK. Ethnobotanical, phytochemical, and pharmacological properties of Cerbera manghas L. J. Biosci. 2021; 46:25-33. Doi: 10.1007/s12038-021-00146-6.

Islam MS, Ahmed Z. A Pharmacological and phytochemical review on Cerbera odollam a plant with significant ethnomedicinal value. EJPMR. 2017; 4(12):19-21.

Chan EWC, Wong SK, Chan HT, Baba S, Kezuka M. Cerbera are coastal trees with promising anticancer properties but lethal toxicity: A short review. J. Chin Pharm Sci. 2016; 25(3):161-169. Doi: 10.5246/jcps.2016.03.019.

Alvarado-Cárdenas LO, Ochoterena H. A Phylogenetic Analysis of the Cascabela-Thevetia Species Complex (Plumerieae, Apocynaceae) Based on Morphology. Ann Mo Bot Gard. 2007; 94(2):298-323. Doi: 10.3417/0026-6493(2007)94[298:APAOTC]2.0.CO;2.

Menezes RG, Usman MS, Hussain SA, Madadin M, Siddiqi TJ, Fatima H, Ram P, Pasha SB, Senthilkumaran S, Fatima TQ, et al. Cerbera odollam toxicity: Review. J. Forensic Leg Med. 2018; 58:113-116. Doi: 10.1016/j.jflm.2018.05.007.

Wermuth ME, Vohra R, Bowman N, Furbee RB, Rusyniak DE. Cardiac toxicity from intentional ingestion of pong-pong seeds (Cerbera odollam). J. Emerg Med. 2018; 55(4):507-511. Doi: 10.1016/j.jemermed.2018.05.021.

Fok H, Victor P, Bradberry S, Eddleston M. Novel methods of self-poisoning: repeated cardenolide poisoning after accessing Cerbera odollam seeds via the internet. Clin Toxicol. 2018; 56(4):304-306. Doi: 10.1080/15563650.2017.1369543.

Iawsipo P, Choksawangkarn W, Promdan C, Nilkasam P. Antibacterial and antioxidant activities of Cerbera manghas and C. odollam leaf extracts. Burapha Sci J. 2017; 22:1-12.

Iqbal Z, Iqbal MS, Mishra K. Screening of antioxidant property in medicinal plants belonging to the family Apocynaceae. Asian J. Pharm Clin Res. 2017; 10:415-418.

Saxena M, Jadhav EB, Sankhla MS, Singhal M, Parihar K, Awasthi KK, Awasthi G. Bintaro (Cerbera odollam and Cerbera manghas): an overview of its eco-friendly use, pharmacology, and toxicology. Environ Sci Pollut Res. 2023; 30:71970-71983. Doi: 10.1007/s11356-022-22585-w.

Yi YS, Cho JY, Kim D. Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway. J. Ethnopharmacol. 2016; 193:387-396.

Sahoo A, Marar T. Phytochemical analysis, antioxidant assay and antimicrobial activity in leaf extracts of Cerbera odollam Gaertn. Pharmacogn J. 2018; 10(2): 285-292. Doi: 10.5530/pj.2018.2.50.

Sakushima A, Nishibe S, Hisada S, Noro Y, Hisada Y. Studies on the constituents of Apocynaceae plants; Isolation of flavonol glycosides and some other components from the leaves of Cerbera manghas L (1). Yakugaku Zasshi. 1976; 96(8):1046-1048. Doi: 10.1248/yakushi1947.98.10_1395.

Abe F, Yamauchi T. Studies on Cerbera I. Cardiac glycosides in the seeds, bark, and leaves of Cerbera manghas L. Chem Pharm Bull. 1977; 25(10): 2744-2748 Doi: 10.1248/cpb.25.2744.

Zhang XP, Pei YH, Liu MS, Kang SL, Zhang JQ. Chemical constituents from the leaves of Cerbera manghas. Asian Pac J. Trop Med. 2010; 3(2):109-111.

Cao LL. Chemical constituents in fruits of mangrove plant Cerbera manghas L. Chinese Pharm J. 2013; 24:1052-1056.

Laphookhieo S, Cheenpracha S, Karalai C, Chantrapromma S, Ratapaa Y, Ponglimanont C, Chantrapromma K. Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry. 2004; 65:507-510. Doi: 10.1016/j.phytochem.2003.10.019.

Carlier J, Guitton J, Bévalot F, Fanton L, Gaillard Y. The principal toxic glycosidic steroids in Cerbera manghas L. seeds: Identification of cerberin, neriifolin, tanghinin and deacetyltanghinin by UHPLC–HRMS/MS, quantification by UHPLC–PDA-MS. J. Chromatogr B. 2014; 962:1-8. Doi: 10.1016/j.jchromb.2014.05.014.

Cheenpracha S, Karalai C, Rat-A-Pa Y, Ponglimanont C, Chantrapromma K. New cytotoxic cardenolide glycoside from the seeds of Cerbera manghas. Chem Pharm Bull. 2004; 52(8):1023-1025. Doi: 10.1248/cpb.52.1023.

Abe F, Okabe H, Yamauchi T. Studies on Cerbera II. Cerbinal and its derivatives, yellow pigment in the bark of Cerbera manghas L. Chem Pharm Bull. 1977; 25(12):3422-3424. Doi: 10.1248/cpb.25.3422.

Sakushima A, Hisada S, Ogihara Y, Nishibe S. Studies on the constituents of Apocynaceae plants. Gas Chromatography-Mass Spectrometric determination of new flavonoid triglycosides from the leaves of Cerbera manghas L. Chem Pharm Bull. 1980; 28:1219-1223. Doi: 10.1248/cpb.28.1219.

Sakushima A, Nishibe S, Hisada S. A new flavonol glycoside from Cerbera Manghas. Phytochemistry. 1980; 19:712-713. Doi: 10.1016/0031-9422(80)87052-X.

Yamauchi T, Abe F, Wan ASC. Cardenolide Monoglycosides from the Leaves of Cerbera odollam and Cerbera manghas (Cerbera. III). Chem Pharm Bull. 1987; 35(7):2744-2749. Doi: 10.1248/cpb.35.2744.

Yamauchi T, Abe F, Wan ASC. Studies on Cerbera. IV. Polar Cardenolide Glycosides from the Leaves of Cerbera odollam and Cerbera manghas. Chem Pharm Bull. 1987; 35(12):4813-4818. Doi: 10.1248/cpb.35.4813.

Yamauchi T, Abe F, Wan ASC. Studies on Cerbera. V. Minor Glycosides of 17α-Digitoxigenin from the stems of genus Cerbera. Chem Pharm Bull. 1987; 35(12):4993-4995. Doi: 10.1248/cpb.35.4993.

Abe F, Yamauchi T, Wan ASC. Lignans related to olivil from genus Cerbera (Cerbera VI). Chem Pharm Bull. 1988; 36(2):795-799. Doi: 10.1248/cpb.36.795

Abe F, Yamauchi T, Wan ASC. Sesqui-, sester- and trilignans from stems of Cerbera manghas and C. odollam. Phytochemistry. 1988; 27(11):3627-3631. Doi: 10.1016/0031-9422(88)80780-5.

Abe F, Yamauchi T, Wan ASC. Cerberalignans J-N, oligolignans from Cerbera manghas. Phytochemistry. 1989; 28:3473-3476. Doi: 10.1016/0031-9422(89)80367-X.

Abe F, Yamauchi T, Wan ASC. Normonoterpenoids and their allopyranosides from the leaves of Cerbera species (Studies on Cerbera. VIII). Chem Pharm Bull. 1989; 37:2639-2642. Doi: 10.1248/cpb.37.2639.

Yamauchi T, Abe F, Wan ASC. 10-O-benzoyltheveside and 10-dehydrogeniposide from the leaves of Cerbera manghas. Phytochemistry. 1990; 29(7):2327-2328. Doi: 10.1016/0031-9422(90)83063-7.

Abe F, Yamauchi T. 10-Carboxyloganin, normonoterpenoid gluosides and dinormonoterpenoid glucosides from the leaves of Cerbera manghas (Studies on Cerbera. 10). Chem Pharm Bull. 1996; 44(10):1797-1800. Doi: 10.1248/cpb.44.1797.

Chang LC, Gills JJ, Bhat KPL, Luyengi L, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities. Bioorg Med Chem Lett. 2000; 10:2431-2434. Doi: 10.1016/S0960-894X(00)00477-7.

Zhang XP, Liu MS, Zhang JQ, Kang SL, Pei YH. Chemical constituents from the bark of Cerbera manghas. J. Asian Nat Prod Res. 2009; 11(1):75-78. Doi: 10.1080/10286020802514531.

Zhang XP, Liu MS, Pei YH, Zhang JQ, Kang SL. Phenylpropionic acid derivates from the bark of Cerbera manghas. Fitoterapia. 2010; 81(7):852–854. Doi: 10.1016/j.fitote.2010.05.010.

Hasan CM, Kuddus MR, Rumi F, Masud MM. Phytochemical screening and antioxidant activity studies of Cerbera odollam Gaertn. Int J. Pharm Biol Sci. 2011; 2(1):413-418.

Zhang XP, Pei YH, Liu MS, Kang SL, Zhang JQ. Triterpenoids from the leaves of Cerbera manghas. Nat Prod Res Develop. 2011; 23(3):443-445.

Rahman MS, Faisal A, Hasan CM, Ahsan M, Mahsud MM. Chemical and Biological Investigations of Cerbera odollam Gaertn. Dhaka Univ J. Pharm Sci. 2017; 16(2):179-186.

Nurhanan MY, Asiah O, Ilham MAM, Syarifah MMS, Norhayati I, Sahira HL. Anti-proliferative activities of 32 Malaysian plant species in breast cancer cell lines. J. Trop For Sci. 2008; 20(2):77-81.

Yunos, Nurhanan M, Osman A, Jauri MH, Sallehudin NJ. Mutalip SSM. The In Vitro Anti-Cancer Activities of 17βH-Neriifolin Isolated from Cerbera odollam and its Binding Activity on Na+, K+-ATPase. Curr Pharm Biotechmol. 2020; 21(1):37-44. Doi: 10.2174/1389201020666190917154850.

Syarifah MMS, Nurhanan MY, Haffiz JM, Ilham AM, Getha K, Asiah O, Norhayati I, Sahira LH, Suryani SA. Potential anticancer compound from Cerbera. J. Trop For Sci. 2011; 23(1):89-96.

Zhao Q, Guo YW, Feng B, Li L, Huang CG, Jiao BH. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011; 82(5): 735-741. Doi: 10.1016/j.fitote.2011.03.004.

Wang GF, Guo YW, Feng B, Li L, Huang CG, Jiao BH. Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells. Environ Toxicol Pharmacol. 2010; 30(1):31-36. Doi: 10.1016/j.etap.2010.03.012.

Indrayanto G, Putra GS, Suhud F. Chapter six-Validation of in-vitro bioassay methods: Application in herbal drug research. Profiles Drug Subs Exci Relat Methodol. 2021; 46:273-307. Doi: 10.1016/bs.podrm.2020.07.005

Feng B, Guo YW, Huang CG, Li L, Chen RH, Jiao BH. 2’-epi-2’-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. Induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Chem Biol Interact. 2010; 183(1):142-153. Doi: 10.1016/j.cbi.2009.10.012.

Feng B, Guo YW, Huang CG, Li L, Chen RH, Jiao BH. β-D-Glucosyl-(1–4)-α-l-thevetosides of 17β-digitoxigenin from seeds of Cerbera manghas L. induces apoptosis in human hepatocellular carcinoma HepG2 cells. Exper Toxicol Pathol. 2012; 64(5):403-410. Doi: 10.1016/j.etp.2010.10.005.

Rozirwan R, Hamid H, Redho YN, Rezi A, Nadila NK, Fauziyah F, Wike AEP, Riris A. Antioxidant activity, total phenolic, phytochemical content, and HPLC profile of selected mangrove species from Tanjung Api-Api port area, South Sumatra, Indonesia. Trop J Nat Prod Res. 2023; 7(7):3482-3489.

Monjur-Al-Hossain ASM, Sarkar S, Saha S, Hossain ML, Hasan MM, Biological assessment on Cerbera manghas (linn.). Pharmacology online. 2013; 1:155-160.

Musdja MY, Aeni M, Djajanegara I. Comparison of antibacterial activities leaves extracts of Cerbera manghas and leaves extracts of Azadirachta indica against Klebsiella pneumoniae. Asian J. Pharm Clin Res. 2018; 11(3):51-55.

Musdja MY, Chadidjah, Djajanegara I. Antibacterial activity of dichloromethane and ethyl acetate extracts of bintaro leaf (Cerbera manghas, linn) against Staphylococcus aureus and Escherichia coli. Int J. Curr Res. 2019; 11(1):398-402.

Rizal S, Dewi H, Utomo TP. , Effect of solvent types on antibacterial activity of bintaro (Cerbera mangas L.) meat and seeds extract. J. Tek Ind Has Pert. 2015; 20(1):51-64.

Sukmawati D. Antagonism mechanism of fungal contamination animal feed using phylloplane yeasts isolated from the bintaro plant (Cerbera manghas) Bekasi in Java, Indonesia. Int J. Curr Microbiol App Sci. 2016; 5:63-74.

Ahmed F, Amin R, Shahid IZ, Sobhani MME. Antibacterial, cytotoxic and neuropharmacological activities of Cerbera odollam seeds. Orient Pharm Exp Med. 2008; 8(4):323-328. Doi: 10.3742/OPEM.2008.8.4.323.

Chu SY, Singh H, Ahmad MS, Mamat AS, Lee BB. Phytochemical screening of antifungal biocompounds from fruits and leaves extract of Cerbera odollam Gaertn. Malays Appl Biol. 2015; 44(3):75-79.

Utami S. Insecticide on spp. Pest in Laboratory Scale. J. Penelit Hut Tanam. 2010; 7(4):211 -220.

Hashim R, Boon JG, Sulaiman O, Kawamura F, Lee CY. Evaluation of the decay resistance properties of Cerbera odollam extracts and their influence on properties of particleboard. Int Biodeterior Biodegradation. 2009; 63(8):1013-1017. Doi: 10.1016/j.ibiod.2009.07. 002.

Komalamisra N, Trongtokit Y, Rongsriyam Y, Apiwathnasorn C. Screening for larvicidal activity in some Thai plants against four mosquito vector species. Southeast Asian J. Trop Med Public Health. 2005; 36(6):1412.

Tarmadi D, Gunandini DJ, Yusuf S. Larvicidal activity of Cerbera odollam Gaertn against a dengue vector, Aedes aegypti (Diptera: Culicidae), J-SustaiN. 2018; 175-188. Doi: 10.1007/978-981-10-5430-3_14.

Haryanta D, Susilo A, Sa’adah TT. Repelence of bintaro plant extract (Cerbera manghas) against pod-sucking insects (Riptortus linearis) (Hemiptera). Int J. Biol Biomed Eng. 2020; 14:229-238. Doi: 10.46300/91011.2020.14.30.

Somsroi P, Chaiyong S. Effect of Suicide Tree Crude Extract (Cerbera odollam Gaerth.) on Common Cutworm (Spodoptera litura Fabricius). Rajabhat Agric. 2016; 15(1):16-21.

Utami S, Syaufina L, Haneda NF. Toxic effect of crude extract of bintaro leaf (Cerbera odollam Gaertn) on larvae Spodoptera litura of Fabricius. J. Ilmu Pert Ind. 2010; 15(2): 96-100.

Sholahuddin AH, Subchan W, Prihatin J. Toxicity of granules of bintaro leaf extract (Cerbera odollam Gaertn.) on armyworm (Spodoptera litura Fab.). Bioedukasi. 2018; 16(1):15-21. Doi: 10.19184/bioedu.v16i1.7717.

Permana TI, Sasmitasari NID, Susetyarini E, Nuryady MM, Dinindra AM, Agustin JU, Lutfi MA, Ayu P, Alimatul Z. Bintaro leaves (Cerbera manghas): Toxicity to Aedes aegypti instar III larvas. J. Kes Masy. 2022; 17(4):509-516.

Susilo A, Haryanta D, Sa’adah TT. Response of Riptortus linearis towards the aplication of Bintaro (Cerbera manghas) leaf extract, Eurasia. J. Biosci. 2019; 13:2217-2224.

Tarmadi D, Prianto AH, Guswenrivo I, Kartika T, Yusuf S. Influence of bintaro (Cerbera odollam Gaertn) and kecubung (Brugmansia candida Pers) extract against subterranean termite Coptotermes sp. J. Trop Wood Sci Tech. 2007; 5(1): 38-42.

Tarmadi D, Himmi SK, Yusuf S. The efficacy of the oleic acid isolated from Cerbera manghas L. seed against a subterranean termite, Coptotermes gestroi Wasmann and a drywood termite, Cryptotermes cynocephalus Light. Procedia Environ Scien. 2014; 20: 772-777. DOI 10.1016/j.proenv.2014.03.093.

Meisyara D, Tarmadi D, Zulfitri A, Fajar A, Ismayati M, Himmi SK, Kartika T, Guswenrivo I, Yusuf S. Larvicidal Activity of Bintaro (Cerbera odollam) against Culex quinquefasciatus. IOP Conf Ser Earth Environ Sci. 2020; 591:012010.