<i>Musanga cecropioides</i> (Cecropiaceae) Attenuates Carbon Tetrachloride-Induced NonAlcoholic Fatty Liver Disease in Wistar Rats
https://www.doi.org/10.26538/tjnpr/v2i11.4
Keywords:
Musanga cecropioides, Antioxidants, Hepatotoxicity, Carbon-tetrachlorideAbstract
Musanga cecropioides (M. cecropioides) is a medicinal plant used traditionally in Africa to induce labour, reduce elevated blood pressure, reduce high blood sugar as well as inhibit dysentery. In this study, the in vivo hepatoprotective activity of M. cecropioides was investigated in carbon tetrachloride (CCl4)-treated wistar rats. Animals were randomized into 5 groups with group 1 serving as control while animals in groups 2 to 5 were administered CCl4 (30% v/v with olive oil). Animals in groups 3 and 4 were pretreated with 250 and 500 mg/kg M. cecropioides, respectively, whereas group 5 animals (control group) were pretreated with 25 mg/kg silymarin (standard liver protective drug). Following treatment, alterations in biochemical parameters such as serum alanine amino-transferases (ALT), aspartate amino-transferases (AST), alkaline phosphatase (ALP), total protein (TP), Catalase (CAT), Superoxide Dismutase (SOD) and Malondialdehyde (MDA) as well as histopathological changes in the liver of experimental rats were investigated. Findings show increased serum biochemical and antioxidant profiles (AST, ALT, ALP and MDA), reduced TP, CAT and SOD as well as increased fat deposits and inflammatory infiltrates in the liver sections of animals treated with CCl4. However, following pretreatment with M. cecropioides and silymarin, altered biochemical parameters were observed to be retrieving towards normal while the histo-architecture of the liver was markedly improved. These results suggest that M. cecropioides could be a potent hepatoprotective agent against CCl4-induced liver
injury and these activities might in part, be attributed to the high total phenolic contents earlier reported to be present in this plant.
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