Protective Effect of Toraja Robusta Coffee (Coffee cane-Nora) against Muscle Damage Due to Exercise on Balb/C Mice http://www.doi.org/10.26538/tjnpr/v7i12.33

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Published: Dec 31, 2023
Keywords:
Skeletal muscle troponin, Physical activity, Muscle damage, Glutathione peroxidase, Coffee, Antioxidant

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Andi W. F. Al-Ghifari
Sport Health Master Program, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia
Gadis M. Sari
Sport Health Master Program, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia
Damayanti Tinduh
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia
Bambang Purwanto
Sport Health Master Program, Facuyhgglty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia
Tri H. Yuliawati
Department of Anatomy, Histology, and Pharmacology Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

Abstract

Excessive physical activity can increase oxidative stress, and oxidative stress has been identified as the primary cause of exercise-induced muscle damage. Coffee is a natural product that contains antioxidants that can mitigate oxidative stress. The study was aimed to test the protective effects of Toraja Robusta coffee against muscle damage, measured through Skeletal muscle Troponin I (sTnI) serum level, muscle histology, and Glutathione peroxidase (GPx) activity. Twenty-four 8-week-old mice with an approximate weight of 20 grams were randomly assigned into four groups: the Toraja robusta coffee treatment group and three control groups: normal, placebo, and N-Acetylcysteine (NAC) control groups. The results of this study showed that the sTnI levels in the blood serum of the coffee treatment group were significantly lower compared to the NAC control group (p = 0.017) and the placebo control group (p= 0.024) but not significantly different from the normal control group (p = 0.915) (p < 0.05). The activity of GPx was higher in the coffee and NAC-treated groups compared with the placebo group (p = 0.004). This study concluded that Toraja robusta coffee protects muscles against damage, which is characterised by low serum levels of sTnI. Additional research is needed to elucidate the mechanism(s) of skeletal muscle protection by coffee intake and its potential to prevent other health issues.

Article Details

How to Cite
Al-Ghifari, A. W. F., Sari, G. M., Tinduh, D., Purwanto, B., & Yuliawati, T. H. (2023). Protective Effect of Toraja Robusta Coffee (Coffee cane-Nora) against Muscle Damage Due to Exercise on Balb/C Mice: http://www.doi.org/10.26538/tjnpr/v7i12.33. Tropical Journal of Natural Product Research (TJNPR), 7(12), 5601-5605. https://tjnpr.org/index.php/home/article/view/3203
Issue
Vol. 7 No. 12 (2023): Tropical Journal of Natural Product Research (TJNPR)
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biographies

Andi W. F. Al-Ghifari, Sport Health Master Program, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

Department of Physiology, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

Gadis M. Sari, Sport Health Master Program, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

Department of Physiology, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

Damayanti Tinduh, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

Dr. Soetomo General Academic Hospital, Mayjen. Prof. Dr. Moestopo 6-8,60286, Surabaya, Indonesia

Bambang Purwanto, Sport Health Master Program, Facuyhgglty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

Department of Physiology, Faculty of Medicine, Airlangga University, Campus A, Mayjen. Prof. Dr. Moestopo 47, 60132, Surabaya, Indonesia

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