Effects of Aframomum melegueta K. Schum. Leaf on Monosodium Glutamate and High Fat Diet-Induced Obesity in Wistar Rat doi.org/10.26538/tjnpr/v6i6.21
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Abstract
Overweight and obesity are described as abnormal or excessive fat accumulation which presents a serious health risk. Natural products, particularly medicinal plants, are believed to possess potential anti-obesity agents. This study investigated the effects of aqueous leaf extract of A. melegueta on monosodium glutamate (MSG) and high fat diet (HFD)-induced obesity in Wistar rats with a view to employing the plant as a new class of anti-obesity agent. The Wistar rats (65) of both sexes were randomly grouped into 13 (n = 5). Thereafter, obesity was induced via subcutaneous injection of MSG (2 and 4 mg/g bwt) in the rat neonates and HFD using three models. The rats were then treated with A. melegueta extract (200 and 400 mg/kg bwt); and the concentrations of insulin, leptin, lipid (total triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol) were determined spectrophotometrically. Also lipase activity, cardiac, and atherogenic indices were etermined. Results showed that the administration of MSG and HFD caused a significant (p < 0.05) increase in insulin-leptin levels and lipase activity. However, the parameters were significantly reduced when treated with the extract. The alterations in lipid profile, atherogenic, and cardiac indices in obese rats were restored to near normal following the administration of the extract. The study concluded that A. melegueta leaf possessed anti-obesity property; justifying its use in folk medicine.
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